Tougher immigration measures increase fears of deportation, but do not change future migration plans

Continuing with his second term agenda in spite of the shutdown, President Obama recently called for Congress to pass an immigration reform bill by the end of the year. Looking back at the failed attempts in 2006 and 2007, it is clear that any bill will be accompanied by extensive debates over border security and enforcement. But how effective are these policies? Catalina Amuedo-Dorantes, Thitima Puttitanun, and Ana Martinez-Donate examine the impact strict state measures to curb illegal immigration; their findings cast doubt on the effectiveness of tougher immigration policies at curbing the desire of those who have been deported to re-enter the United States

Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms

Background: Thyroid receptors, TRα and TRβ, are involved in important physiological functions such as metabolism, cholesterol level and heart activities. Whereas metabolism increase and cholesterol level lowering could be achieved by TRβ isoform activation, TRα activation affects heart rates. Therefore, β-selective thyromimetics have been developed as promising drug-candidates for treatment of obesity and elevated cholesterol level. GC-1 [3,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)-phenoxy acetic acid] has ability to lower LDL cholesterol with 600- to 1400-fold more potency and approximately two- to threefold more efficacy than atorvastatin (Lipitor©) in studies in rats, mice and monkeys. Results: To investigate GC-1 specificity, we solved crystal structures and performed molecular dynamics simulations of both isoforms complexed with GC-1. Crystal structures reveal that, in TRα Arg228 is observed in multiple conformations, an effect triggered by the differences in the interactions between GC-1 and Ser277 or the corresponding asparagine (Asn331) of TRβ. The corresponding Arg282 of TRβ is observed in only one single stable conformation, interacting effectively with the ligand. Molecular dynamics support this model: our simulations show that the multiple conformations can be observed for the Arg228 in TRα, in which the ligand interacts either strongly with the ligand or with the Ser277 residue. In contrast, a single stable Arg282 conformation is observed for TRβ, in which it strongly interacts with both GC-1 and the Asn331. Conclusion: Our analysis suggests that the key factors for GC-1 selectivity are the presence of an oxyacetic acid ester oxygen and the absence of the amino group relative to T3. These results shed light into the β-selectivity of GC-1 and may assist the development of new compounds with potential as drug candidates to the treatment of hypercholesterolemia and obesity

The next phases of the Migrante Project: Study protocol to expand an observatory of migrant health on the Mexico—U.S. border

BackgroundMexican migrants traveling across the Mexico-United States (U.S.) border region represent a large, highly mobile, and socially vulnerable subset of Mexican nationals. Population-level health data for this group is hard to obtain given their geographic dispersion, mobility, and largely unauthorized status in the U.S. Over the last 14 years, the Migrante Project has implemented a unique migration framework and novel methodological approach to generate population-level estimates of disease burden and healthcare access for migrants traversing the Mexico-U.S. border. This paper describes the rationale and history of the Migrante Project and the protocol for the next phases of the project.Methods/designIn the next phases, two probability, face-to-face surveys of Mexican migrant flows will be conducted at key crossing points in Tijuana, Ciudad Juarez, and Matamoros (N = 1,200 each). Both survey waves will obtain data on demographics, migration history, health status, health care access, COVID-19 history, and from biometric tests. In addition, the first survey will focus on non-communicable disease (NCD), while the second will dive deeper into mental health and substance use. The project will also pilot test the feasibility of a longitudinal dimension with 90 survey respondents that will be re-interviewed by phone 6 months after completing the face-to-face baseline survey.DiscussionInterview and biometric data from the Migrante project will help to characterize health care access and health status and identify variations in NCD-related outcomes, mental health, and substance use across migration phases. The results will also set the basis for a future longitudinal extension of this migrant health observatory. Analyses of previous Migrante data, paired with data from these upcoming phases, can shed light on the impact of health care and immigration policies on migrants’ health and inform policy and programmatic responses to improve migrant health in sending, transit, and receiving communities

Safe-zone schools and the academic performance of children in mixed-status households: Evidence from the between the lines study.

In response to the intensification of immigration enforcement in the interior of the USA, some school districts have implemented safe-zone policies to protect students academic progression and well-being. Using primary data from a sample of US-born children of unauthorized migrants, we document the detrimental effect of stricter immigration enforcement on childrens educational outcomes and the benefits of safe-zone policies. Our analyses show that restricting immigration authorities access to schools and providing counseling on immigration-related issues are crucial policy components in strengthening childrens focus, effort, expectations, parental involvement, and relationships. These findings highlight the damaging impact of immigration enforcement on US-citizen children in mixed-status households and advance our understanding of the role of local policies in mitigating these effects

Examining Barriers to Implementation of Electronic Benefit Transfer (EBT) in Farmers Markets: Perspectives from Market Managers

Farmers markets are generally considered one of the healthiest places to purchase food. However, less than 1% of food assistance dollars are redeemed at farmers markets. Because farmers markets have operated historically as cash operations, they are still experimenting and struggling to find ways to redeem electronic food share benefits. Much work on electronic benefit transfer (EBT) has focused on barriers from users' perspectives. Farmers markets have often been overlooked during the transition from food stamps to EBT. This paper takes an in-depth look at barriers and facilitators to successful implementation of EBT at farmers markets from the market manager's perspective. The researchers interviewed a semi¬random geographic sample of farmers market managers across Wisconsin (N=13) to determine if and how the electronic Supplemental Nutrition Assistance Program benefits are redeemed at their market and identify factors that impede or aid EBT redemption. Data were analyzed using grounded theory analysis. Several positive and negative themes emerged from the interviews as factors associated with successful EBT programs, including community support, perceived match of EBT with market mission, stable financing, perceived benefit to vendors, and vendor acceptance of EBT. Farmers markets have the potential to reduce food insecurity through EBT redemption. Understanding the main barriers as well as effective strategies for successful implementation of EBT in farmers markets is imperative to realize the full potential of this program. Understanding difficulties from market managers' perspectives is important to inform future policy initiatives to streamline reimbursement at farmers markets