25 research outputs found
Building Korean Sign Language Augmentation (KoSLA) Corpus with Data Augmentation Technique
We present an efficient framework of corpus for sign language translation.
Aided with a simple but dramatic data augmentation technique, our method
converts text into annotated forms with minimum information loss. Sign
languages are composed of manual signals, non-manual signals, and iconic
features. According to professional sign language interpreters, non-manual
signals such as facial expressions and gestures play an important role in
conveying exact meaning. By considering the linguistic features of sign
language, our proposed framework is a first and unique attempt to build a
multimodal sign language augmentation corpus (hereinafter referred to as the
KoSLA corpus) containing both manual and non-manual modalities. The corpus we
built demonstrates confident results in the hospital context, showing improved
performance with augmented datasets. To overcome data scarcity, we resorted to
data augmentation techniques such as synonym replacement to boost the
efficiency of our translation model and available data, while maintaining
grammatical and semantic structures of sign language. For the experimental
support, we verify the effectiveness of data augmentation technique and
usefulness of our corpus by performing a translation task between normal
sentences and sign language annotations on two tokenizers. The result was
convincing, proving that the BLEU scores with the KoSLA corpus were
significant
Identification of Novel Substrates for the Serine Protease HTRA1 in the Human RPE Secretome
Characterization of HTRA1 physiological substrates in the context of RPE extracellular milieu reveals pathways linking HTRA1 to complement pathway and age-related macular degeneration
Clinical implication of mass-spectrometry-based selected reaction monitoring (SRM) assay in non-small cell lung cancer (NSCLC) patients exhibiting ALK gene rearrangement.
Quantitative Multiplexed Proteomics Could Assist Therapeutic Decision Making in Non-Small Cell Lung Cancer Patients with Ambiguous ALK Test Results
Therapeutic guidance in non-small cell lung cancer (NSCLC) tumors that are positive for anaplastic lymphoma kinase (ALK) fluorescent in situ hybridization (FISH), but negative for ALK immunohistochemistry, is still challenging. Parallel routine screening of 4588 NSCLC cases identified 22 discordant cases. We rechecked these samples using ALK antibodies and selected reaction monitoring (SRM) quantitative multiplexed proteomics screening multiple protein targets, including ALK and MET for the ALK tyrosine kinase inhibitor (TKI), and FR-alpha, hENT1, RRM1, TUBB3, ERCC1, and XRCC1 for chemotherapy. The presence of ALK (31.8%), MET (36.4%), FR-alpha (72.7%), hENT1 (18.2%), RRM1 (31.8%), TUBB3 (72.9%), ERCC1 (4.5%), and a low level of XRCC1 (54.4%) correlated with clinical outcomes. SRM was more sensitive than the ALK D5F3 assay. Among the eight cases receiving ALK TKI, four cases with ALK or MET detected by SRM had complete or partial responses, whereas four cases without ALK or MET showed progression. Twenty-seven treatment outcomes from 20 cases were assessed and cases expressing more than half of the specific predictive proteins were sensitive to matching therapeutic agents and showed longer progression-free survival than the other cases (p < 0.001). SRM showed a potential role in therapeutic decision making in NSCLC patients with ambiguous ALK test results
Secreted Proteome Profiling in Human RPE Cell Cultures Derived from Donors with Age Related Macular Degeneration and Age Matched Healthy Donors J. Proteome Res.
Wireless phototherapeutic contact lenses and glasses with red light-emitting diodes
Light-mediated therapeutics have attracted considerable attention as a method for the treatment of ophthalmologic diseases, such as age-related macular degeneration, because of their non-invasiveness and the effectiveness to ameliorate the oxidative stress of retinal cells. However, the current phototherapeutic devices are opaque, bulky, and tethered forms, so they are not feasible for use in continuous treatment during the patient's daily life. Herein, we report wireless, wearable phototherapeutic devices with red light-emitting diodes for continuous treatments. Red light-emitting diodes were formed to be conformal to three-dimensional surfaces of glasses and contact lenses. Furthermore, fabricated light-emitting diodes had either transparency or a miniaturized size so that the user's view is not obstructed. Also, these devices were operated wirelessly with control of the light intensity. In addition, in-vitro and in-vivo tests using human retinal epithelial cells and a live rabbit demonstrated the effectiveness and reliable operation as phototherapeutic devices