Supplementary table: Cost–effectiveness of overactive bladder treatments from a US commercial and payer perspective

These are peer-reviewed supplementary materials for the article 'Cost–effectiveness of overactive bladder treatments from a US commercial and payer perspective' published in the Journal of Comparative Effectiveness Research.Supplementary Table 1: Model inputs for efficacy.Aim: The cost–effectiveness of treatment options (anticholinergics, β3-adrenoceptor agonists, onabotulinumtoxinA, sacral nerve stimulation and percutaneous tibial stimulation [the latter two including new rechargeable neurostimulators]) for the management of overactive bladder (OAB) were compared with best supportive care (BSC) using a previously published Markov model. Materials & methods: Cost–effectiveness was evaluated over a 15-year time horizon, and sensitivity analyses were performed using 2- and 5-year horizons. Discontinuation rates, resource utilization, and costs were derived from published sources. Results: UsingMedicare and commercial costs over a 15-year time period, onabotulinumtoxinA 100U had incremental cost–effectiveness ratios (ICERs) gained of $39,591/qualityadjusted life-year (QALY) and$42,255/QALY, respectively, versus BSC, which were the lowest ICERs of all assessed treatments. The sensitivity analyses at 2- and 5-year horizons also showed onabotulinumtoxinA to be the most cost-effective of all assessed treatments versus BSC. Conclusion: OnabotulinumtoxinA 100U is currently the most cost-effective treatment for OAB.</p

ANM Discovery–SNPs associated with age at natural menopause (ANM) in African American women from the PAGE Study.

<p>Tests of association at p≤1E-04 from single SNP linear regressions adjusted for study site and principal components in 1,860 African American women from the PAGE Study are shown. For each significant test of association, the chromosome, rs number, nearest gene, location, coded allele, beta, standard error (SE), and p-value are given. Genes listed are nearest genes to the SNP as measured from the transcription start site for upstream SNPs or the transcription stop site for downstream SNPs. Abbreviations: CAF, coded allele frequency.</p

Regional Association Plots for Age at Natural Menopause in African American women in the PAGE Study.

<p>Locus Zoom plots for selected gene regions in age at natural menopause analysis. Vertical axis is the –log₁₀ of the p-value, the horizontal axis is the chromosomal position. Each dot represents a SNP tested for association with age at natural menopause in 1,860 African American women from the PAGE Study. Linkage disequilibrium between the most significant SNP, listed at the top of each plot, and the other SNPs in the plot is shown by the r² legend in each plot. (A) Locus Zoom plot for the <i>APOE</i> region, with rs78916952 the most significant SNP in the region. (B) Locus Zoom plot for the <i>MCM8</i> region; rs237688 is the most significant SNP in the plot region. (C) <i>FSHB</i> region Locus Zoom plot; rs605765 is the most significant SNP in the plot region. (D) Locus Zoom plot of the <i>BRSK1</i> region with rs11672111 as the most significant SNP in the plot region.</p

Comparison of GWAS-identified ANM variants in African American women in PAGE Study.

<p>Comparison of previously reported SNPs associated with ANM in European and Chinese descent women to 1,860 African American women from the PAGE Study. Data presented are for the previously identified SNP. If the previously identified SNP was not directly genotyped in present study, data are shown for the best proxy SNP based on linkage disequilibrium calculated from the International HapMap Project CEU data.</p

Regional Association Plots for Age at Menarche in African American women in the PAGE Study.

<p>Locus Zoom plots for selected gene regions in age at menarche analysis. Vertical axis is –log₁₀ of the p-value, the horizontal axis is the chromosomal position. Each dot represents a SNP tested for association with age at natural menopause in 1,860 African American women from the PAGE Study. Approximate linkage disequilibrium between the most significant SNP, listed at the top of each plot, and the other SNPs in the plot is shown by the r² legend in each plot. (A) Locus Zoom plot for the <i>CYP19A1</i> region, with rs10519297 the most significant SNP in the region. (B) Locus Zoom plot for the <i>FTO</i> region; rs2689243 was the most significant SNP in the plot region. (C) <i>LIN28B</i> region Locus Zoom plot; rs408949 was the most significant SNP in the plot region. (D) Locus Zoom plot of the <i>CYP1B1</i> region; rs13391045 was the most significant SNP in the plot region.</p