Virginia College Access Resource Study: Region One Report

This research brief shares the results of a MERC study commissioned by the State Council of Higher Education for Virginia (SCHEV) and supported by Virginia 529 about college access in central Virginia. The purpose of college access providers is discussed as well the current areas of need. A list of access providers in Virginia are listed at the end of the brief

Metabolomics Identifies multiple candidate biomarkers to diagnose and stage human African trypanosomiasis

Treatment for human African trypanosomiasis is dependent on the species of trypanosome causing the disease and the stage of the disease (stage 1 defined by parasites being present in blood and lymphatics whilst for stage 2, parasites are found beyond the blood-brain barrier in the cerebrospinal fluid (CSF)). Currently, staging relies upon detecting the very low number of parasites or elevated white blood cell numbers in CSF. Improved staging is desirable, as is the elimination of the need for lumbar puncture. Here we use metabolomics to probe samples of CSF, plasma and urine from 40 Angolan patients infected with Trypanosoma brucei gambiense, at different disease stages. Urine samples provided no robust markers indicative of infection or stage of infection due to inherent variability in urine concentrations. Biomarkers in CSF were able to distinguish patients at stage 1 or advanced stage 2 with absolute specificity. Eleven metabolites clearly distinguished the stage in most patients and two of these (neopterin and 5-hydroxytryptophan) showed 100% specificity and sensitivity between our stage 1 and advanced stage 2 samples. Neopterin is an inflammatory biomarker previously shown in CSF of stage 2 but not stage 1 patients. 5-hydroxytryptophan is an important metabolite in the serotonin synthetic pathway, the key pathway in determining somnolence, thus offering a possible link to the eponymous symptoms of “sleeping sickness”. Plasma also yielded several biomarkers clearly indicative of the presence (87% sensitivity and 95% specificity) and stage of disease (92% sensitivity and 81% specificity). A logistic regression model including these metabolites showed clear separation of patients being either at stage 1 or advanced stage 2 or indeed diseased (both stages) versus control

Trauma-informed Dialectical Behavior Therapy for Dissociative Identity Disorder

Dissociative symptoms are regarded as forms of disconnection from external stimuli, internal experiences, and interpersonal relationships. The Contextual Trauma Treatment (CTT) model for survivors of prolonged childhood abuse integrates Dialectical Behavior Therapy (DBT) treatment. DBT enhances capacities for skillful interactions with others, and identifying and tolerating emotional experiences through the use of didactically-taught skill-based groups that balance encouraging acceptance of difficulties with the recognition of the need for change. This presentation will provide an overview of CTT for conceptualizing dissociation in the context of family of origin environment and development, and describe how TRIP integrates trauma-informed and DBT-informed treatment

How the Fruits of Growth Were Distributed Among Working-Age Families in the United States and Germany in the 1980s

We use cross-sectional and longitudinal data from Germany (Socio-Economic Panel) and the United States (Panel Study on Income Dynamics) to show how the income distribution changed over the 1980s business cycle in these two countries. Consistent with other researchers we find income inequality in the United States increased over the peak years of the 1980s business cycle and that the middle of the income distribution shrank. However, we also find that the great bulk of the disappearing middle shifted to the right— became richer— over the period. Hence, it was disproportionate gains from growth rather than the “immiseration” of the middle class that explains the rise in inequality over the period. Focusing on the upswing years of the 1980s business cycle, we find that cross-sectional comparisons understate the gains to persons who lived in working-age households over the period. This is especially true of persons who were living in nonworking households at the start of the period. We find similar results for Germany. However, regardless of the data used, the distribution of the fruits of economic growth during the 1980s were more evenly distributed in Germany than in the United States. Economic gains by persons living in nonworking households and in households headed by relatively low educated workers in Germany were much closer to the gains of other working age households than was true in the United States

Recounting Winners and Losers in the 1980s: A Critique of Income Distribution Measurement Methodology

The 1980s have been characterized as a time when the “rich got richer and the poor got poorer.” Using a cross-over point methodology used in several recent studies, we show how sensitive the measurement of winners and losers can be to seemingly small differences in methodological practice. Specifically, we show sensitivity to the years compared, the income sharing unit chosen, and the inflation index used. Our results show that these and other studies of economic well-being exaggerate losses by mixing cyclical with cross-cycle effect

Peering beneath the Canadian crust

This work was funded by Leverhume Trust research project grant RPG-2013- 332. Equipment was provided by the NERC’s GEF, SEIS-UK: Loan 986. Many thanks to residents of Nova Scotia and New Brunswick for allowing us to install seismometers on their land, and for their interest and hospitality: Ben and Elizabeth Pooley, Calvin and Mary Fraser, Kirk Munn, Mary Guptill and Delbé Comeau, Simeon Comeau, George Klass, Greg McHone and the Grand Manan Museum, Heiner and Alison Josenhans, Bev and Ian Cameron, Maurice Mazerolle, Russell and Debbie Parrott. Thanks to Dalhousie University, Halifax, NS, especially to Mladen Nedimovic, Darlene van de Rijt and Anne Bannon for logistical assistance.Peer reviewedPublisher PD

Evidence of egg laying grounds for critically endangered flapper skate (Dipturus intermedius) off Orkney, UK

Funding information: Surveys were supported by a grant from WWF Netherlands. The writing of this paper was funded via the SeaMonitor project; supported by the European Union’s INTERREG VA Programme (Environment Theme) and managed by the Special EU Programmes Body (SEUPB) (Grant IVA5060).Essential fish habitats (EFHs) are critical for fish life-history events, including spawning, breeding, feeding or growth. Here we provide evidence of EFH for the Critically Endangered flapper skate (Dipturus intermedius) in the waters around the Orkney Isles, Scotland based on citizen-science observation data. The habitats of potential egg laying sites were parametrised as >20m depth, with boulders or exposed bedrock, in moderate current flow (0.3 - 2.8 knots) with low sedimentation. This information provides a significant contribution to our understanding of EFH for flapper skate. Publisher PDFPeer reviewe

Peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO) restores carbapenem susceptibility to NDM-1-positive pathogens in vitro and in vivo

The objective of this study was to test the efficacy of an inhibitor of the New Delhi metallo-β- lactamase (NDM-1). Inhibiting expression of this type of antibiotic-resistance gene has the potential to restore antibiotic susceptibility in all bacteria carrying the gene.Methods: We have constructed a peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO) that selectively inhibits the expression of NDM-1 and examined its ability to restore susceptibility to meropenem in vitro and in vivo.Results:In vitro, the PPMO reduced the MIC of meropenem for three different genera of pathogens that express NDM-1. In a murine model of lethal E. coli sepsis, the PPMO improved survival (92%) and reduced systemic bacterial burden when given concomitantly with meropenem.Conclusions: These data show that a PPMO can restore antibiotic susceptibility in vitro and in vivo and that the combination of PPMO and meropenem may have therapeutic potential against certain class B carbapenem- resistant infections in multiple genera of Gram-negative pathogens