The formation of Laurentia : Evidence from shear wave splitting

The authors would like to thank A. Walker for invaluable help understanding the MSAT forward modelling code, as well as A. Boyce, L. Petrescu, and C. Ogden of the ICcratons group for numerous enlightening conversations about Canadian Precam- brian geology and beyond. M.V. Liddell is funded by an Imperial College President’s Scholarship. F.A. Darbyshire is supported by the Natural Sciences and Environment Research Council of Canada through their Discovery Grant and Canada Research Chair programmes.Peer reviewedPublisher PD

The Inherent Power of the Federal Courts to Compel Participation in Nonbinding Forms of Alternative Dispute Resolution

This article argues that the federal district courts have the inherent authority to compel litigants to participate in nonbinding Alternative Dispute Resolution processes, when local statutes or rules are not in place to authorize such compulsion. The authors assert five reasons why they believe the courts have this power: (1) the federal courts\u27 inherent powers are necessary to manage the courts\u27 affairs; (2) inherent powers are key to achieving the orderly and expeditious disposition of cases; (3) the courts\u27 inherent powers are strong, giving courts the ability to control the conduct of those appearing before them; (4) the use of Alternative Dispute Resolution eases crowded dockets by fostering settlement; and (5) all civil cases are to use Alternative Dispute Resolution processes

Robotic distal ureterectomy with psoas hitch and ureteroneocystostomy: Surgical technique and outcomes

AbstractUse of the da Vinci® surgical robotic system has expanded to numerous upper and lower urinary tract procedures. We describe our surgical technique and perioperative outcome of robotic distal ureterectomy with psoas hitch and ureteroneocystostomy for distal ureteral pathologies. Eight patients with a median age of 69.5 years old underwent robotic distal ureterectomy with psoas hitch and ureteroneocystostomy between April 2009 and August 2014. The entirety of all cases was performed robotically by a single surgeon at a tertiary academic medical center. Median operative time was 285 min (range: 210–360 min), estimated blood loss was 50 mL (range: 50–75 mL) and median length of hospital stay was 2.5 days (range: 1–6 days). There was one post-operative complication, a readmission for dehydration (Clavien I). It suggests that robotic distal ureterectomy with psoas hitch and ureteroneocystostomy is a safe and effective minimally invasive alternative for patients with distal ureteral pathology

Stepgrandparenting and Grandparenting: A Perception of Grandparenting Behaviors and Roles

Family Relations And Child Developmen

Engaging Teaching Dilemmas to Foster Culturally Responsive and Antiracist Teaching Practice

This special Issue of the Race and Pedagogy Journal features artist statements and images of projects created by Master of Arts in Teaching candidates in their master’s coursework focused on developing anti-racist and culturally responsive teaching practices

A step into the unknown:universities and the governance of regional economic development

As the social and economic landscape changes, universities are coming under growing pressure to contribute to the economic development of their localities. This paper explores the increasing trends towards universities as key actors in the governance of regional economic development through activities to support economic and entrepreneurship development in their regions. A case study is presented of an institution in the UK which is increasingly situating itself in the economic governance sphere. Drawing on the experiences of those working at the coalface of economic governance activities, the opportunities and potential challenges faced by a university when engaging in such activities are explored. The ultimate goal of this paper is to shed light on universities’ activities in the realm of regional economic governance, an area currently under-explored in extant literature

Acute Trauma Factor Associations With Suicidality Across the First 5 Years After Traumatic Brain Injury

AbstractObjectiveTo determine whether severity of head and extracranial injuries (ECI) is associated with suicidal ideation (SI) or suicide attempt (SA) after traumatic brain injury (TBI).DesignFactors associated with SI and SA were assessed in this inception cohort study using data collected 1, 2, and 5 years post-TBI from the National Trauma Data Bank and Traumatic Brain Injury Model Systems (TBIMS) databases.SettingLevel I trauma centers, inpatient rehabilitation centers, and the community.ParticipantsParticipants with TBI from 15 TBIMS Centers with linked National Trauma Data Bank trauma data (N=3575).InterventionsNot applicable.Main Outcome MeasuresSI was measured via the Patient Health Questionnaire 9 (question 9). SA in the last year was assessed via interview. ECI was measured by the Injury Severity Scale (nonhead) and categorized as none, mild, moderate, or severe.ResultsThere were 293 (8.2%) participants who had SI without SA and 109 (3.0%) who had SA at least once in the first 5 years postinjury. Random effects logit modeling showed a higher likelihood of SI when ECI was severe (odds ratio=2.73; 95% confidence interval, 1.55–4.82; P=.001). Drug use at time of injury was also associated with SI (odds ratio=1.69; 95% confidence interval, 1.11–2.86; P=.015). Severity of ECI was not associated with SA.ConclusionsSevere ECI carried a nearly 3-fold increase in the odds of SI after TBI, but it was not related to SA. Head injury severity and less severe ECI were not associated with SI or SA. These findings warrant additional work to identify factors associated with severe ECI that make individuals more susceptible to SI after TBI

A comprehensive and high-resolution genome-wide response of p53 to stress

Tumor suppressor p53 regulates transcription of stress-response genes. Many p53 targets remain undiscovered because of uncertainty as to where p53 binds in the genome and the fact that few genes reside near p53-bound recognition elements (REs). Using chromatin immunoprecipitation followed by exonuclease treatment (ChIP-exo), we associated p53 with 2,183 unsplit REs. REs were positionally constrained with other REs and other regulatory elements, which may reflect structurally organized p53 interactions. Surprisingly, stress resulted in increased occupancy of transcription factor IIB (TFIIB) and RNA polymerase (Pol) II near REs, which was reduced when p53 was present. A subset associated with antisense RNA near stress-response genes. The combination of high-confidence locations for p53/REs, TFIIB/Pol II, and their changes in response to stress allowed us to identify 151 high-confidence p53-regulated genes, substantially increasing the number of p53 targets. These genes composed a large portion of a predefined DNA-damage stress-response network. Thus, p53 plays a comprehensive role in regulating the stress-response network, including regulating noncoding transcription