Aterosklerotske promjene krvnih sudova glave i vrata u bolesnika sa sistemskim eritemskim lupusom

The aim of this study was to evaluate the presence of atherosclerotic plaque of head and neck blood vessels and to determine the dynamics of circulation through the brain blood vessels in patients with systemic lupus erythematosus (SLE). In 35 patients with SLE aged 37.67±9.96 and whose disease lasted 3.8±4.51 years, Doppler carotid ultrasonography was used to identify the presence of intima-media thickness or atherosclerotic plaque. Brain perfusion scintigraphy was done in 15 out of 35 patients in order to evaluate the dynamics in circulation through carotid and cerebral media arteries. Measured by Doppler ultrasound, 2/35 of examined lupus patients had a plaque and the 2/35 had an intimal-medial thickness. The results of perfusion scintigraphy in 15 examined patients out 35 with SLE showed that 5/15 had mild circulatory changes in carotidogram. 4/15 patients had mild changes in cerebra media arteries circulation, 1/15 had severe changes in carotid circulation and 5/15 patients had normal brain scintigraphy finding. Some of the patients with SLE have atherosclerotic changes and only the early detection of atherosclerosis may provide an opportunity for therapeutic intervention.Cilj rada je evaluirati prisustvo aterosklerotskog plaka na krvnim sudovima glave i vrata te procjeniti promjene u cirkulaciji kroz krvne sudove mozga u bolesnika sa sistemskim eritemskim lupusom (SLE). U 35 pacijenata sa SLE prosječne životne dobi 37,67±9,96 godina i dužine trajanja bolesti od 3,8±4,51godina uradila se Doppler ultrasonografija karotidnih arterija da bi se ustanovilo eventualno prisustvo zadebljanja intima-media zida krvnog suda ili prisustvo aterosklerotskog plaka. Perfuziona scintigrafija mozga uradi se u 15 od 35 pacijenata sa ciljem procjene promjena u cirkulaciji kroz krvne sudove mozga. Mjereno ultrazvučno 2/35 pacijenata sa lupusom su imali aterosklerotski plak, a 2/35 zadebljanje zida krvnog suda. Rezultati scintigrafije mozga su pokazali blage cirkulatorne promjene na karotidogramu u 5/15 pacijenata, 4/15 pacijenata su imali blage promjene u cirkulaciji kroz aa. cerebri mediae. 1/15 je imao teške promjene u karotidnoj cirkulaciji, dok je u 5/15 pacijenata nalaz bio uredan. U pacijenata sa SLE postoji određen stepen aterosklerotskih promjena te samo rana dijegnoza može doprinjeti pravodobnoj terapijskoj intervenciji

Case presentation – thyroid lymphoma

Malignant tumors of the thyroid gland account for about 1% of thenewly diagnosed malignant tumors each year, and their incidence inwomen is twice the incidence in men. According to the WHO classification (2004) thyroid tumors are divided into: carcinoma of the thyroid, adenoma and similar tumors, and other thyroid tumors which include: teratomas, angiosarcomas, paragangliomas and others, as well as primary lymphomas and plasmacytomas. Primary thyroid lymphomasare defined as lymphomas which originate in the thyroid gland. This study presents the case of a 68-year-old patient with a thyroid lymphoma, which caused compression of the airways. In the patientpresented there was reduced activity of the thyroid gland. The dominant symptoms were: breathing difficulties, hoarse voice and the enlargement of the thyroid. An ultrasound examination was performedbefore surgery on the neck, which showed a multinodular thyroid,with compromised and compressed trachea to the right and rear. Anemergency surgical procedure was performed to reduce the tumor.Pathohistological diagnosis confirmed diffuse large B cell lymphoma.The aim of the study was to present a patient with a thyroid lymphoma, who had previously not had any immunological changes to the gland,that is, she had not had any chronic lymphocyte thyroiditis, but due to the compressive syndrome it was necessary to perform an emergencysurgical procedure to reduce the tumor

Epidemiological, clinical and pathological characteristics of colorectal cancer in patients treated at the Clinical Center of Tuzla University

Aim To investigate hospital morbidity and incidence of colorectal cancer (CRC) in the Tuzla Canton between 2000 and 2004, as well as mortality incidence and degree of disease progression. Methods A total of 383 patients were enrolled in this study, all of them with CRC. Pathohistological analyses were performed in all patients after colonoscopy. Afterwards, the patients underwent surgery and obtained material was also pathohistologically analyzed in order to perform the Astler-Coller classification and the classification of the location of CRC. Results In the period 2000-2004 in the Tuzla Canton there were 383 newly diagnosed patients with CRC. The average age of the patients was 62±12 years, and the incidence was equally distributed per genders. Rectal tumour was noted in 145 (37.9%) patients, and in 238 (62.1%) tumor was found elsewhere in the colon. Average incidence of the CRC was 15.73/100,000, with a dramaticincrease in incidence in 2003 of 27.40/100,000. The average mortality incidence during the study was 6.89/100,000, and the largest number of the patients (339, 88.6%) was in an advanced stage of the disease. Conclusion There has been a significant increase in the number of newly detected cases of CRC in the Tuzla Canton during 2000- 2004, which implies the need for initiating a National Early CRC Detection Programme