16 research outputs found
Π’Π΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΡ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΎΡΠΈΡΡΠΊΠΈ ΠΈ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΌΠ°Π³ΠΈΡΡΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π½Π΅ΡΡΠ΅ΠΏΡΠΎΠ²ΠΎΠ΄Π° "ΠΠΎΡΡΠΎΡΠ½Π°Ρ Π‘ΠΈΠ±ΠΈΡΡ-Π’ΠΈΡ ΠΈΠΉ ΠΠΊΠ΅Π°Π½" Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΌΠΎΠ±ΠΈΠ»ΡΠ½ΡΡ ΠΊΠ°ΠΌΠ΅Ρ Π·Π°ΠΏΡΡΠΊΠ°-ΠΏΡΠΈΠ΅ΠΌΠ° Π²Π½ΡΡΡΠΈΡΡΡΠ±Π½ΡΡ ΡΡΡΡΠΎΠΉΡΡΠ²
Π Π²ΡΠΏΡΡΠΊΠ½ΠΎΠΉ ΠΊΠ²Π°Π»ΠΈΡΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΠ΅ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½Π° ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΌΠΎΠ±ΠΈΠ»ΡΠ½ΡΡ
ΠΊΠ°ΠΌΠ΅Ρ Π·Π°ΠΏΡΡΠΊΠ°-ΠΏΡΠΈΠ΅ΠΌΠ° ΠΎΡΠΈΡΡΠ½ΡΡ
ΡΡΡΡΠΎΠΉΡΡΠ² ΠΈ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ½Π°ΡΡΠ΄ΠΎΠ² Π½Π° ΠΏΡΠΈΠΌΠ΅ΡΠ΅ ΡΡΡΠ±ΠΎΠΏΡΠΎΠ²ΠΎΠ΄Π° "ΠΠΎΡΡΠΎΡΠ½Π°Ρ Π‘ΠΈΠ±ΠΈΡΡ - Π’ΠΈΡ
ΠΈΠΉ ΠΠΊΠ΅Π°Π½. Π Π°ΡΡΡΠΈΡΠ°Π½Π° Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠ°Ρ ΡΠΎΠ»ΡΠΈΠ½Π° ΡΡΠ΅Π½ΠΊΠΈ ΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠ² ΠΊΠ°ΠΌΠ΅ΡΡ.In the final qualifying work, the technology of using mobile pig trap station was considered using the example of the "Eastern Siberia - Pacific Ocean" pipeline. The required thickness of the wall of the chamber elements was calculated
Π’Π΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ΅ΡΠ΅Π½ΠΈΡ Π΄Π»Ρ ΡΡΡΠΎΠΈΡΠ΅Π»ΡΡΡΠ²Π° ΡΠ°Π·Π²Π΅Π΄ΠΎΡΠ½ΠΎΠΉ Π²Π΅ΡΡΠΈΠΊΠ°Π»ΡΠ½ΠΎΠΉ ΡΠΊΠ²Π°ΠΆΠΈΠ½Ρ Π³Π»ΡΠ±ΠΈΠ½ΠΎΠΉ 2900 ΠΌΠ΅ΡΡΠΎΠ² Π½Π° Π½Π΅ΡΡΡΠ½ΠΎΠΌ ΠΌΠ΅ΡΡΠΎΡΠΎΠΆΠ΄Π΅Π½ΠΈΠΈ (Π’ΠΎΠΌΡΠΊΠ°Ρ ΠΎΠ±Π»Π°ΡΡΡ)
ΠΡΠΏΡΡΠΊΠ½Π°Ρ ΠΊΠ²Π°Π»ΠΈΡΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½Π°Ρ ΡΠ°Π±ΠΎΡΠ° ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π° ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠΌΡ ΡΠ΅ΡΠ΅Π½ΠΈΡ Π·Π°Π΄Π°ΡΠΈ Π±ΡΡΠ΅Π½ΠΈΡ ΡΠ°Π·Π²Π΅Π΄ΡΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠΊΠ²Π°ΠΆΠΈΠ½Ρ, ΠΎΠΏΡΠΈΠΌΠΈΠ·Π°ΡΠΈΠΈ ΠΏΡΠΎΡΠ΅ΡΡΠ° Π±ΡΡΠ΅Π½ΠΈΡ, ΠΏΠΎΠ΄Π±ΠΎΡ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΠ³ΠΎ ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠ° ΠΈ Π²ΡΠ±ΠΎΡ ΠΏΡΠΎΠΌΡΠ²ΠΎΡΠ½ΠΎΠΉ ΠΆΠΈΠ΄ΠΊΠΎΡΡΠΈ ΠΈ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠΈΡ
ΡΠ΅ΠΆΠΈΠΌΠΎΠ² Π±ΡΡΠ΅Π½ΠΈΡ, ΡΠ°ΠΊΠΆΠ΅ ΡΠ°Π±ΠΎΡΠ° Π²ΠΊΠ»ΡΡΠ°Π΅Ρ Π² ΡΠ΅ΠΌΡ ΠΈ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°Π΅Ρ ΡΠ°ΠΊΡΡ ΡΠ΅ΠΌΡ ΠΊΠ°ΠΊ ΠΏΡΠΎΠ±Π»Π΅ΠΌ ΠΊΠ°ΠΊ Π²ΡΠ½ΠΎΡ ΠΏΠ΅ΡΠΊΠ° ΠΈΠ· ΠΏΠ»Π°ΡΡΠ° ΠΈ ΡΠΏΠΎΡΠΎΠ±Ρ ΠΏΡΠ΅Π΄ΠΎΡΠ²ΡΠ°ΡΠ΅Π½ΠΈΡ ΠΏΠΎΠ΄ΠΎΠ±Π½ΡΡ
Π½Π΅Π³Π°ΡΠΈΠ²Π½ΡΡ
ΠΌΠΎΠΌΠ΅Π½ΡΠΎΠ². Π’Π°ΠΊ ΠΆΠ΅ Π² ΡΠ°Π±ΠΎΡΠ΅ ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΡΡ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠ°ΡΡΠ΅ΡΠΎΠ² ΡΠ΅ΠΆΠΈΠΌΠ° Π±ΡΡΠ΅Π½ΠΈΡ, ΠΏΠΎΠ΄ΡΠΎΠ±Π½ΠΎΠ΅ ΠΎΠ±ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠ΅ Π²ΡΠ±ΠΎΡΠ° ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠ° ΠΈ ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Ρ ΠΏΡΡΠΈ ΠΎΠΏΡΠΈΠΌΠΈΠ·Π°ΡΠΈΠΈ Π΄Π΅ΠΉΡΡΠ²ΡΡΡΠ΅Π³ΠΎ ΠΏΡΠΎΠ΅ΠΊΡΠ°.The final qualification work is devoted to the practical solution of the problem of drilling an exploration well, optimizing the drilling process, selecting the necessary tools and choosing the washing liquid and subsequent drilling modes, and the work also includes and considers such a topic as problems such as sand removal from the reservoir and ways to prevent such negative moments. The paper also contains the results of calculations of the drilling mode, a detailed justification for the choice of the tool, and offers ways to optimize the current project. This work contains an introduction, sections, conclusion, and a list of references
The ubiquitin-like molecule interferon-stimulated gene 15 (ISG15) is a potential prognostic marker in human breast cancer
INTRODUCTION: ISG15 is an ubiquitin-like molecule that is strongly upregulated by type I interferons as a primary response to diverse microbial and cellular stress stimuli. However, alterations in the ISG15 signalling pathway have also been found in several human tumour entities. To the best of our knowledge, in the current study we present for the first time a systematic characterisation of ISG15 expression in human breast cancer and normal breast tissue both at the mRNA and protein level. METHOD: Using semiquantitative real-time PCR, cDNA dot-blot hybridisation and immunohistochemistry, we systematically analysed ISG15 expression in invasive breast carcinomas (n = 910) and normal breast tissues (n = 135). ISG15 protein expression was analysed in two independent cohorts on tissue microarrays; in an initial evaluation set of 179 breast carcinomas and 51 normal breast tissues; and in a second large validation set of 646 breast carcinomas and 10 normal breast tissues. In addition, a collection of benign and malignant mammary cell lines (n = 9) were investigated for ISG15 expression. RESULTS: ISG15 was overexpressed in breast carcinoma cells compared with normal breast tissue, both at the RNA and protein level. Recurrence-free (p = 0.030), event-free (p = 0.001) and overall (p = 0.001) survival analyses showed a significant correlation between ISG15 overexpression and unfavourable prognosis. CONCLUSION: Therefore, ISG15 may represent a novel breast tumour marker with prognostic significance and may be helpful in selecting patients for and predicting response to the treatment of human breast cancer
Seven gypsies all in a row
A lady follows the gypsies. Her husband follows her - but she is happy to foresake her land and live with her dark-eyed gypsy