Domestic Violence and its Determinants: A cross-sectional study among women in a slum of Kolkata

Background: Violence against women is one of the major public health and human rights issue in the world today which is prevalent in all human societies irrespective of religion, socioeconomic status, and culture. Therefore, recognized as a significant barrier to women empowerment and their health. Aims & Objectives: The aim of this study was to find out the extent of different type of domestic violence and to identify various risk factors for domestic violence against married women. Material & Methods: The present study is a community based cross-sectional study carried out in a slum of Kolkata. Simple random sampling technique was used for the selection of the samples. The study participants were interviewed using a pretested semi-structured questionnaire. Result: 97 married women participated in the study. 32.9% of the study population reported some form of domestic violence. In a logistic regression analysis, significant association was found between domestic violence and alcohol abuse by the spouse, level of education of the spouse, per capita income and occupation of the women. Conclusion: This study confirms, high prevalence of all forms of violence against women, which underscores the need for policy makers to increase their recognition of domestic violence as a critical target in public health concern

Physics Potential of the ICAL detector at the India-based Neutrino Observatory (INO)

The upcoming 50 kt magnetized iron calorimeter (ICAL) detector at the India-based Neutrino Observatory (INO) is designed to study the atmospheric neutrinos and antineutrinos separately over a wide range of energies and path lengths. The primary focus of this experiment is to explore the Earth matter effects by observing the energy and zenith angle dependence of the atmospheric neutrinos in the multi-GeV range. This study will be crucial to address some of the outstanding issues in neutrino oscillation physics, including the fundamental issue of neutrino mass hierarchy. In this document, we present the physics potential of the detector as obtained from realistic detector simulations. We describe the simulation framework, the neutrino interactions in the detector, and the expected response of the detector to particles traversing it. The ICAL detector can determine the energy and direction of the muons to a high precision, and in addition, its sensitivity to multi-GeV hadrons increases its physics reach substantially. Its charge identification capability, and hence its ability to distinguish neutrinos from antineutrinos, makes it an efficient detector for determining the neutrino mass hierarchy. In this report, we outline the analyses carried out for the determination of neutrino mass hierarchy and precision measurements of atmospheric neutrino mixing parameters at ICAL, and give the expected physics reach of the detector with 10 years of runtime. We also explore the potential of ICAL for probing new physics scenarios like CPT violation and the presence of magnetic monopoles.Comment: 139 pages, Physics White Paper of the ICAL (INO) Collaboration, Contents identical with the version published in Pramana - J. Physic

Utility of therapeutic drug monitoring in identifying clinically significant interactions between St. John's Wort and prescription drugs

BACKGROUND : The general population widely uses herbal medicines, as they are regarded as effective and safe. St. John's wort, which is an effective herbal antidepressant, exhibits both pharmacokinetic and pharmacodynamic interactions with several drugs. The aim of this review was to highlight the clinically significant interactions of St. John's wort with drugs that require to be monitored to assess their therapeutic effect. METHODS : Published literature was searched using electronic databases, such as MEDLINE, PubMed, and Elsevier ScienceDirect using terms such as “herbal medicine,” “herbal toxicity,” “legislation herbal medicine,” “drug–herb interactions,” “St. John's wort,” and “St. John's wort–drug interactions.” Searches were limited to the English language, and there was no restriction on the date of publication. RESULTS : St. John's wort exhibits a number of pharmacokinetic and pharmacodynamic interactions with drugs. The most dangerous interactions occurred when used concurrently with the immunosuppressants, cyclosporine, and tacrolimus (treatment failure or organ rejection) or warfarin (treatment failure resulting in thromboembolic events) or antiretroviral agents (treatment failure and the emergence of new viral variants that are resistant to conventional drugs). CONCLUSIONS : Patients should consult their health care providers before consuming herbal supplements, especially St. John's wort, to avoid potentially dangerous drug–herb interactions.https://journals.lww.com/drug-monitoring/pages/default.aspx2024-02-01hj2023Pharmacolog

Pharmacogenomics of alcohol and drugs of abuse

xi, 240 p. ; 23 c