Detection of [O III] at z~3: A Galaxy above the Main Sequence, Rapidly Assembling its Stellar Mass

We detect bright emission in the far infrared fine structure [O III] 88$\mu$m line from a strong lensing candidate galaxy, H-ATLAS J113526.3-014605, hereafter G12v2.43, at z=3.127, using the $\rm 2^{nd}$ generation Redshift (z) and Early Universe Spectrometer (ZEUS-2) at the Atacama Pathfinder Experiment Telescope (APEX). This is only the fifth detection of this far-IR line from a sub-millimeter galaxy at the epoch of galaxy assembly. The observed [O III] luminosity of $7.1\times10^{9}\,\rm(\frac{10}{\mu})\,\rm{L_{\odot}}\,$ likely arises from HII regions around massive stars, and the amount of Lyman continuum photons required to support the ionization indicate the presence of $(1.2-5.2)\times10^{6}\,\rm(\frac{10}{\mu})$ equivalent O5.5 or higher stars; where $\mu$ would be the lensing magnification factor. The observed line luminosity also requires a minimum mass of $\sim 2\times 10^{8}\,\rm(\frac{10}{\mu})\,\rm{M_{\odot}}\,$ in ionized gas, that is $0.33\%$ of the estimated total molecular gas mass of $6\times10^{10}\,\rm(\frac{10}{\mu})\,\rm{M_{\odot}}\,$. We compile multi-band photometry tracing rest-frame UV to millimeter continuum emission to further constrain the properties of this dusty high redshift star-forming galaxy. Via SED modeling we find G12v2.43 is forming stars at a rate of 916 $\rm(\frac{10}{\mu})\,\rm{M_{\odot}}\,\rm{yr^{-1}}$ and already has a stellar mass of $8\times 10^{10}\,\rm(\frac{10}{\mu})\,\rm{M_{\odot}}\,$. We also constrain the age of the current starburst to be $\leqslant$ 5 million years, making G12v2.43 a gas rich galaxy lying above the star-forming main sequence at z$\sim$3, undergoing a growth spurt and, could be on the main sequence within the derived gas depletion timescale of $\sim$66 million years.Comment: 11 pages, 3 figures, accepted for publication in The Astrophysical Journa

Coronavirus Disease 2019 (COVID-19): Origin, Impact, and Drug Development

At the end of December 2019, in Wuhan, China, a rapidly spreading unknown virus was reported to have caused coronavirus disease of 2019 (COVID-19). Origin linked to Wuhan’s wholesale food market where live animals are sold. This disease is caused by SARS Coronavirus-2 (SARS-CoV-2), which is closely related to the Severe Acute Respiratory Coronavirus (SARS-CoV) and the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). This virus shares a high sequence identity with bat-derived SARS-like Coronavirus, which indicating its zoonotic origin. The virus spread globally, provoking widespread attention and panic. This Coronavirus is highly pathogenic and causes mild to severe respiratory disorders. Later, it was declared a global pandemic by the World Health Organization (WHO) due to its highly infectious nature and worldwide mortality rate. This virus is a single-stranded, positive-sense RNA genome, and its genome length about 26 to 32 kb that infects a broad range of vertebrates. The researchers worldwide focus on establishing treatment strategies on drug and vaccine development to prevent this COVID-19 pandemic. A drug repurposing approach has been used to identify a rapid treatment for the people affected by COVID-19, which could be cost-effective and bypass some Food and Drug Association (FDA) regulations to move quickly in phase-3 trials. However, there is no promising therapeutic option available yet. This book chapter addresses current information about the COVID-19 disease, including its origins, impacts, and the novel potential drug candidates that can help treat the COVID-19

Ground based THz Spectroscopy of Obscured Starbursts in the Early Universe enabled by the 2nd generation z(Redshift) & Early Universe Spectrometer

Supplemental file(s) description: Real-time video of automated wire bonding for ZEUS-2 200/645um arraysGalaxies were surprisingly dusty in the early Universe, with more than half of the light emitted from stars being absorbed by dust within the system and re-radiated into far infrared (FIR, ~50-150micron) wavelengths. Dusty star forming galaxies (DSFGs) dominate the co-moving star formation rate density of the Universe that peaks around redshift, z~2, making it compelling to study them in rest frame FIR bands. From galaxies at z>1, the FIR line emission from abundant ions like O++, C+ and N+, are redshifted into the short sub-mm telluric windows. My thesis work is based on upgrading and deploying the 2nd generation z (Redshift) and Early Universe Spectrometer (ZEUS-2), a long-slit, echelle grating spectrometer optimized to study broad (dv = 300 km/s) spectral lines from galaxies in the 200-650 micron telluric windows using TES bolometers. These far-IR lines being extinction free and major coolants of the gas heated by (young) massive stars, are powerful probes of the physical conditions of the gas and the stellar radiation field. I present results from our observations of the [OIII] 88 micron line in galaxies at redshift, z~3-4, with ZEUS-2 at the Atacama Pathfinder Experiment (APEX) Telescope. To interpret our observations along with ancillary data from optical to radio facilities, we apply photoionization models for HII regions and Photo Dissociation Region (PDR) models and confirm that the galaxies host substantial ongoing obscured star formation. The presence of doubly ionized oxygen suggests hard radiation fields and often elevated ionization parameters that can only be accounted for by a population of massive stars formed during the ongoing starburst, that contribute a large fraction of the infrared luminosity. This work highlights the use of FIR line emission to trace the assembly of current day massive galaxies, details of their stellar populations and physical conditions of the interstellar medium undergoing rapid star-formation activity

Effect of Dietary Phosphorous Restriction on Fibroblast Growth 2 Factor-23 and sKlotho Levels in Patients with Stages 1–2 Chronic Kidney Disease

Hyperphosphatemia has emerged as an independent risk factor for cardiovascular disease (CVD) and excess mortality in chronic kidney disease (CKD). The study evaluates the effect of dietary phosphorus (Ph) restriction (DPhR) at an early stage as a therapeutic strategy for delaying CKD progression and preventing CVD. Methods: This was a one-year interventional study conducted on 79 stage 1 and 2 CKD patients. The dietary phosphorus intake (DPhI), fibroblast growth factor-23 (FGF-23), sKlotho and serum phosphorous (SP) levels were analyzed. Patients were categorized into two groups based on their DPhI, recommended DPhI (RPhI) with <1000 mg/day of dietary phosphorous (dietary counselling) and high DPhI (HPhI) with >1000 mg/day (dietary intervention). For comparisons of differences between the two groups, independent t-test; for correlation analysis, Pearson correlation; for identifying the significant associated risk factors for CKD, binary logistic regression analysis and for comparing the means across the three visits, repeated measures ANOVA were used for statistical analysis. Results: The mean age and glomerular filtration rate (GFR) of CKD patients were 38 ± 12 years and 82.95 ± 16.93 mL/min/1.73 m2. FGF-23, SP, dietary protein and DPhI were significantly higher and sKlotho was significantly lower in HPhI group than RPhI group. In HPhI group; GFR, sKlotho, SP and FGF-23 correlated significantly with DPhI. Risk factors with a statistical bearing on the progression of CKD were animal-based diet, family history of CKD and hypertension. In HPhI group; GFR, DPhI, SP and FGF-23 levels significantly improved within the intervention period whereas a significant increase in sKlotho levels was observed in both the groups. Conclusion: Restricting DPhI emerged as a favorable therapeutic strategy for CKD patients for improving renal function and controlling hyperphosphatemia. The results of the present study may serve as the basis for future interventional studies with dietary phosphate restriction in the initial stages of CKD that would preserve renal function. Highlights: Early restriction of dietary phosphorus prevents decline in eGFR, elevation in FGF23 and increases Klotho levels

Discovery of a Dusty, Chemically Mature Companion to a z ∼ 4 Starburst Galaxy in JWST ERS Data

We report the discovery of two companion sources to a strongly lensed galaxy SPT0418-47 (“ring”) at redshift 4.225, targeted by the JWST Early Release Science program. We confirm that these sources are at a similar redshift to the ring based on H α detected in the NIRSpec spectrum and [C ii ] λ 158 μ m line from the Atacama Large Millimeter/submillimeter Array (ALMA). Using multiple spectral lines detected in JWST/NIRSpec, the rest-frame optical to infrared images from NIRCam and MIRI and far-infrared dust continuum detected by ALMA, we argue that the newly discovered sources are actually lensed images of the same companion galaxy SPT0418-SE, hereafter referred to “SE,” located within 5 kpc in the source plane of the ring. The star formation rate derived using [C ii ] and the dust continuum puts a lower limit of 17 M _☉ yr ^−1 , while the SFR _H _α is estimated to be >2 times lower, thereby confirming that SE is a dust-obscured star-forming galaxy. Analysis using optical strong line diagnostics suggests that SE has near-solar elemental abundance, while the ring appears to have supersolar metallicity O/H and N/O. We attempt to reconcile the high metallicity in this system by invoking early onset of star formation with continuous high star-forming efficiency or by suggesting that optical strong line diagnostics need revision at high redshift. We suggest that SPT0418-47 resides in a massive dark-matter halo with yet-to-be-discovered neighbors. This work highlights the importance of joint analysis of JWST and ALMA data for a deep and complete picture of the early universe

The Next Generation Arecibo Telescope: A preliminary study

The Next Generation Arecibo Telescope (NGAT) was a concept presented in a white paper Roshi et al. (2021) developed by members of the Arecibo staff and user community immediately after the collapse of the 305 m legacy telescope. A phased array of small parabolic antennas placed on a tiltable plate-like structure forms the basis of the NGAT concept. The phased array would function both as a transmitter and as a receiver. This envisioned state of the art instrument would offer capabilities for three research fields, viz. radio astronomy, planetary and space & atmospheric sciences. The proposed structure could be a single plate or a set of closely spaced segments, and in either case it would have an equivalent collecting area of a parabolic dish of size 300 m. In this study we investigate the feasibility of realizing the structure. Our analysis shows that, although a single structure ~300 m in size is achievable, a scientifically competitive instrument 130 to 175 m in size can be developed in a more cost effective manner. We then present an antenna configuration consisting of one hundred and two 13 m diameter dishes. The diameter of an equivalent collecting area single dish would be ~130 m, and the size of the structure would be ~146 m. The weight of the structure is estimated to be 4300 tons which would be 53% of the weight of the Green Bank Telescope. We refer to this configuration as NGAT-130. We present the performance of the NGAT-130 and show that it surpasses all other radar and single dish facilities. Finally, we briefly discuss its competitiveness for radio astronomy, planetary and space & atmospheric science applications.Comment: 6 pages, 5 figures, 1 table, Invited paper for the ICEAA-IEEE APWC conference, Venice, Italy, Oct 9-13, 202

A dense, solar metallicity ISM in the

We present a study of six far-infrared fine structure lines in the z = 4.225 lensed dusty star-forming galaxy SPT 0418−47 to probe the physical conditions of its interstellar medium (ISM). In particular, we report Atacama Pathfinder EXperiment (APEX) detections of the [OI] 145 μm and [OIII] 88 μm lines and Atacama Compact Array (ACA) detections of the [NII] 122 and 205 μm lines. The [OI] 145 μm/[CII] 158 μm line ratio is ∼5× higher compared to the average of local galaxies. We interpret this as evidence that the ISM is dominated by photo-dissociation regions with high gas densities. The line ratios, and in particular those of [OIII] 88 μm and [NII] 122 μm imply that the ISM in SPT 0418−47 is already chemically enriched to nearly solar metallicity. While the strong gravitational amplification was required to detect these lines with APEX, larger samples can be observed with the Atacama Large Millimeter/submillimeter Array (ALMA), and should allow observers to determine if the dense, solar metallicity ISM is common among these highly star-forming galaxies

ZINGRS: ZEUS INvestigated Galaxy Reference Sample

A project to compile multiwavelength data for ZEUS observed galaxies. Work is supported by the National Science Foundation under Grant No. 184789