ID-based Ring Signature and Proxy Ring Signature Schemes from Bilinear Pairings

In 2001, Rivest et al. firstly introduced the concept of ring signatures. A ring signature is a simplified group signature without any manager. It protects the anonymity of a signer. The first scheme proposed by Rivest et al. was based on RSA cryptosystem and certificate based public key setting. The first ring signature scheme based on DLP was proposed by Abe, Ohkubo, and Suzuki. Their scheme is also based on the general certificate-based public key setting too. In 2002, Zhang and Kim proposed a new ID-based ring signature scheme using pairings. Later Lin and Wu proposed a more efficient ID-based ring signature scheme. Both these schemes have some inconsistency in computational aspect. In this paper we propose a new ID-based ring signature scheme and a proxy ring signature scheme. Both the schemes are more efficient than existing one. These schemes also take care of the inconsistencies in above two schemes.Comment: Published with ePrint Archiv

ATP Triggers Human Th9 Cell Differentiation via Nitric Oxide-Mediated mTOR-HIF1α Pathway

Interleukin 9 (IL-9)-producing helper T (Th9) cells have a crucial effector function in inducing allergic inflammation, autoimmunity, immunity to extracellular pathogens and anti-tumor immune responses. Although the cytokines that lead to the differentiation of human Th9 cells have been identified, other factors that support the differentiation of Th9 cells have not been identified yet. Here we show that the extracellular ATP (eATP) induces the differentiation of Th9 cells. We further show that eATP induces the production of nitric oxide (NO), which create a feed forward loop in the differentiation of human Th9 cells, as inhibition of purinergic receptor signaling suppressed the generation of human Th9 cells while exogenous NO could rescue generation of Th9 cells even upon inhibition of purinergic receptor signaling. Moreover, we show that ATP promotes mTOR and HIF1α dependent generation of Th9 cells. Our findings thus identify that ATP induced nitric oxide potentiate HIF1α-mediated metabolic pathway that leads to IL-9 induction in Th9 cells. Here we identified that the ATP-NO-mTOR-HIF1α axis is essential for the generation of human Th9 cells and modulation of this axis may lead to therapeutic intervention of Th9-associated disease conditions