Suicide risk in comorbid bipolar disorder and obsessive-compulsive disorder: A systematic review

The co-occurrence of bipolar disorder (BD) and obsessive-compulsive disorder (OCD) seemed to be a poor prognostic factor associated with greater disability, lower social and occupational functioning, poorer treatment response, and higher suicidal ideas and attempts compared to BD patients

Aripiprazole augmentation in treating comorbid bipolar disorder and obsessive-compulsive disorder

Obsessive-compulsive disorder (OCD) is one of the most difficult additional diagnoses to manage in patients with bipolar disorder (BD) since the gold standard treatment for one disease (antidepressants for OCD) can worsen the other. This case report describes the efficacy of aripiprazole augmentation as maintenance therapy in a young patient with comorbid BD-OCD. Our patient presented complete remission of affective and obsessive-compulsive symptoms with remarkable improvement in social and occupational functioning for 24 months. Adverse drug reactions were not severe enough to result in drug discontinuation. In consideration of the important nosological, clinical and therapeutic implications, future research efforts may lead to more grounded guidelines, which are greatly needed in patients with comorbid BD-OCD

Clinical management of comorbid bipolar disorder and obsessive-compulsive disorder: A case series

Background: Apparent comorbidity between bipolar disorder (BD) and obsessive-compulsive disorder (OCD) is a common condition in psychiatry and it has important nosological and therapeutic implications. Although antidepressants are the first line treatment for OCD, they can induce mood instability in BD. An optimal treatment approach remains to be defined. Methods: Longitudinal clinical observation of three severe OCD patients who developed a manic episode during treatment with different classes of antidepressants. Results: In our cases, three features support the hypothesis of an underlying bipolarity unmasked by the antidepressant used to treat OCD: positive family history for affective disorders, manic switch induced by antidepressant and improvement of affective and obsessive-compulsive symptoms with mood stabilizers and atypical antipsychotics. Conclusions: Osler\u2019s view that medicine should be treatment of diseases, not of symptoms, is consistent with the approach of mood stabilization as a first objective in BD-OCD patients, as opposed to immediate treatment with antidepressants. Only persistent OCD patients should be prescribed antidepressants in as low a dose as feasibl

Conceptual design of a scalable multi-kton superconducting magnetized liquid Argon TPC

We discuss the possibility of new generation neutrino and astroparticle physics experiments exploiting a superconducting magnetized liquid Argon Time Projection Chamber (LAr TPC). The possibility to complement the features of the LAr TPC with those provided by a magnetic field has been considered in the past and has been shown to open new physics opportunities, in particular in the context of a neutrino factory. The experimental operation of a magnetized 10 lt LAr TPC prototype has been recently demonstrated. From basic proof of principle, the main challenge to be addressed is the possibility to magnetize a very large volume of Argon, corresponding to 10 kton or more, for future neutrino physics applications. In this paper we present one such conceptual design.Comment: 4 pages, 1 figure, invited talk at 7th International Workshop on Neutrino Factories and Superbeams (NUFACT05), LNF, Frascati (Rome

The estimation of neutrino fluxes produced by proton-proton collisions at s=14\sqrt{s}=14 TeV of the LHC

Intense and collimated neutrino beams are produced by charm and beauty particle decays from proton-proton collisions at the LHC. A neutrino experiment would be run parasitically without interrupting the LHC physics program during the collider run. We estimate the neutrino fluxes from proton-proton collisions at $\sqrt{s}=14$ TeV of the LHC with the designed luminosity, 10^{34} \lumi. By mounting about 200 tons of fiducial volume of a neutrino detector at 300 \m away from the interaction point, about 150,000 of charged current neutrino events per year can be observable.Comment: 8 pages, Accepted in JHE

The liquid Argon TPC: a powerful detector for future neutrino experiments and proton decay searches

We discuss the possibility of new generation neutrino and astroparticle physics experiments exploiting the liquid Argon Time Projection Chamber (LAr TPC) technique, following a graded strategy that envisions applications with increasing detector masses (from 100 ton to 100 kton). The ICARUS R&D program has already demonstrated that the technology is mature with the test of the T600 detector at surface. Since 2003 we have been working with the conceptual design of a very large LAr TPC with a mass of 50-100 kton to be built by employing a monolithic technology based on the use of industrial, large volume, cryogenic tankers developed by the petro-chemical industry. Such a detector, if realized, would be an ideal match for a Super Beam, Beta Beam or Neutrino Factory, covering a broad physics program that includes the detection of atmospheric, solar and supernova neutrinos, and searches for proton decay, in addition to the rich accelerator neutrino physics program. A "test module" with a mass of the order of 10 kton operated underground or at shallow depth would represent a necessary milestone towards the realization of the 100 kton detector, with an interesting physics program on its own. In parallel, physics is calling for a shorter scale application of the LAr TPC technique at the level of 100 ton mass, for low energy neutrino physics and for use as a near station setup in future long baseline neutrino facilities. We outline here the main physics objectives and the design of such a detector for operation in the upcoming T2K neutrino beam. We finally present the result of a series of R&D studies conducted with the aim of validating the design of the proposed detectors.Comment: 16 pages, 18 figures, Invited talk at High Intensity Physics HIF05, La Biodola, Isola d'Elba (Italy), June 200

Many-core applications to online track reconstruction in HEP experiments

Interest in parallel architectures applied to real time selections is growing in High Energy Physics (HEP) experiments. In this paper we describe performance measurements of Graphic Processing Units (GPUs) and Intel Many Integrated Core architecture (MIC) when applied to a typical HEP online task: the selection of events based on the trajectories of charged particles. We use as benchmark a scaled-up version of the algorithm used at CDF experiment at Tevatron for online track reconstruction - the SVT algorithm - as a realistic test-case for low-latency trigger systems using new computing architectures for LHC experiment. We examine the complexity/performance trade-off in porting existing serial algorithms to many-core devices. Measurements of both data processing and data transfer latency are shown, considering different I/O strategies to/from the parallel devices.Comment: Proceedings for the 20th International Conference on Computing in High Energy and Nuclear Physics (CHEP); missing acks adde

The prevalence and predictors of comorbid bipolar disorder and obsessive-compulsive disorder: A systematic review and meta-analysis

Abstract Background: Although some authors have recently investigated the co-occurrence of anxiety and bipolar disorders, the topic remains insufficiently studied. Defining the prevalence and predictors of BD-OCD comorbidity has important nosological, clinical and therapeutic implications. Methods: A systematic review and meta-analysis was conducted on the prevalence and predictors of comorbid BD-OCD. Relevant papers published through March 30th, 2015 were identified searching the electronic databases MEDLINE, Embase, PsycINFO and the Cochrane Library. Results: 46 articles met inclusion criteria. The pooled prevalence of OCD in BD was 17.0% (95% CI 12.7-22.4%), which was comparable to the results reported by the pooled prevalence of BD in OCD (18.35%, 95% CI 13.2-24.8%). With regard to OCD-BD predictors, a higher mean age predicted a lower prevalence of OCD in BD patients. Sub group meta-analyses reported higher OCD prevalence rates in BD children and adolescents (24.2%, compared to 13.5% in adults), in BD-I patients (24.6%, compared to 13.6% in mixed BD patients), and among population-based studies (22.2%, compared to 13.2% in hospital-based studies). Limitations: Most studies use retrospective assessment scales with low sensitivity in discriminating true ego-dystonic obsessions from depressive ruminations that may bias results towards an overestimation of obsessive symptom prevalence. Conclusions: This first systematic review and meta-analysis of the prevalence and predictors of comorbid BD-OCD confirms that BD-OCD comorbidity is a common condition in psychiatry with children and adolescents and BD-I patients as the most affected subgroups