Can we decrease recurrence of OSSN using Mitomycin C

Aim: To study the effect of topical Mitomycin C on recurrence of OSSN after surgical excision. Materials and methods: This is a Randomized prospective interventional study conducted at Sarojini Devi Eye Hospital /Regional institute of Ophthalmology, Hyderabad. 54 clinically diagnosed cases of OSSN attending department of Oculoplasty between October 2012 to September 2014 were included in the study. 36 were males and 18 were females.Cases already treated were excluded from the study. These cases were randomly divided into two groups of 18 males and 9 females.Both the groups were treated by surgical excision of OSSN with 3mm margin of normal conjunctiva and cryo applied to the bare area by freeze thaw freeze technique. Group A was followed up every month for recurrence. Group B were given topical Mitomycin C 0.04% drops 4 times daily for 4days in a week with 3 days off. This constituteone cycle. Patients were kept for 4 cycles on this therapy. This group is also followed up every month for recurrence upto 2 years. Results: In group A 4 cases (14.8%) developed recurrence of tumor within one year. In group B there was no recurrence. Conclusion: Mitomycin C as adjuvant therapy after surgical excision of OSSN is effective in preventing recurrence. Key words: OSSN (Ocular surface squamous neoplasia), MMC (Mitomycin C), HIV (Human immuno-deficiency virus),HPV (Human papilloma virus).Â