Inter Partes Review: An Early Look at the Numbers

In the roughly two years since inter partes review replaced inter partes reexamination, petitioners have filed almost two-thousand requests for the Patent Trial and Appeal Board to review the validity of issued U.S. patents. As partial data on inter partes review (IPR) has trickled out via the blogosphere, interest from patent practitioners and judges has grown to a fever (and sometimes fevered) pitch. To date, however, no commentator has collected a comprehensive set of statistics on IPR. Moreover, what little data currently exists focuses on overall institution and invalidation rates — data that, alone, gives us little idea whether IPR is thus far accomplishing its original goal of serving as a quick, efficient alternative to defending patent suits filed in federal court, particularly those initiated by non-practicing entities (NPEs). This Essay aims to fill both gaps by reporting the findings of an empirical study tracking the outcome of IPRs and their impact on co-pending litigation. As described in greater detail below, we find that: Petitions for IPR are instituted for at least one challenged claim 84 percent of the time; Among instituted IPRs, all challenged claims are instituted 74 percent of the time; Among IPRs that reach a final decision on the merits, all instituted claims are invalidated or disclaimed more than 77 percent of the time; IPRs challenging NPE-owned patents are more likely to be instituted and, on average, are instituted for a larger share of challenged claims, but have their claims invalidated at a lower rate; Litigation proceeding in parallel with an instituted IPR is stayed about 82 percent of the time.Though it is too early to draw sweeping conclusions from these statistics, they suggest that inter partes review promises to be considerably more potent than inter partes reexamination and, moreover, to have a substantial impact on co-pending patent litigation, particularly suits filed by NPEs

Formulation and Assessment of Neural Network and Multiple Linear Regression Models to predict PM10 Levels in Rourkela, India

The present study has been performed in residential educational campus located in a steel city, Rourkela with an aim to develop forecasting models using multiple linear regression analysis and neural networks of 8 h peak average values of PM10 concentrations. The concentration of air pollutants in ambient air is governed by the meteorological parameters such as atmospheric wind speed, wind direction, relative humidity, temperature etc. This study analyses the influence of temperature, wind speed, wind direction and relative humidity on ambient PM10 concentrations. 60 numbers of 8 hour average PM10 samples have been utilized to develop the forecasting models and 10 numbers of PM10 samples have been used for validation purpose. The validation of developed models revealed that neural network shows better skills in forecasting PM10 concentrations as compared to the MLR model. The MLR and neural network models could forecast 60% and 81% variance of data, respectively

Management of insomnia: current trends

Insomnia is one of the most commonly occurring sleep disorders worldwide.1 With increased prevalence of insomnia the demand of the people seeking pharmacological treatment for this disease is continuously increasing. Numerous options are currently available for its treatment and with our increased understanding of the neurophysiological factors involved in the insomnia continuous research is being conducted to seek newer pharmacological treatments. Recent advancement in treatment of insomnia is the introduction of non-benzodiazepine hypnotic medications such as zaleplon, zolpidem, and eszopiclone. Ramelteon, a melatonin agonist, is also helpful for sleep initiation difficulties. Tri-cyclic antidepressants have long been used for insomnia but use has been limited by unwanted anticholinergic side-effects. A hypocretin/orexin antagonist MK-4035 is presently in clinical trials. Serotonin antagonists and inverse agonists are being investigated for their usefulness in insomnia; newer research examining other mechanisms of action suggest that agents which modulate the histaminergic, serotonergic, melontonergic, and hypocretin/ orexin and perhaps gamma-aminobutyric acid B systems could play a promising role in management of insomnia

Mood, food, traits, and restraint: an experimental investigation of negative affect, borderline personality, and disordered eating

Eating disorders and borderline personality disorder involve several overlapping features, such as impulsivity, negative affectivity, and dissociation. However, few studies have specifically assessed how eating pathology and borderline personality may be related. The present study sought to evaluate this relationship by focusing on one particular area of overlap, negative affectivity. A pilot study assessed the psychometric properties of a dietary restraint measure among undergraduate women (N = 149). In the main study, undergraduate women (N = 307) completed a baseline mood assessment, then viewed a 39-minute sad film either with or without concurrent food presentation. Participants then completed a second mood assessment, and those who received food completed a third mood assessment following a 10-minute post-reflection delay. Results suggest that women reporting more borderline features exhibited greater negative affect across three different time points (baseline, post-movie/food, and post-reflection period), and were more reactive to the sad film. Food presentation appeared to have a small tempering effect on sadness, such that individuals who received food reported relatively less sadness after viewing the film when compared to those who did not receive food. However, actual quantity of food consumption was associated with improvements in mood only for women reporting higher levels of borderline features. Finally, highscorers on dietary restraint measures consumed greater quantities of food than their lowscoring counterparts. In sum, these data suggest that women with borderline personality features may be at elevated risk for developing problems with binge-eating, as consuming larger quantities of food appeared to have a tempering effect on their negative mood and specific feelings of sadness. Further, results are consistent with earlier findings in that reported efforts to restrain dietary intake were associated with greater food consumption in response to negative affect, and this relationship may need to be addressed in treating individuals with problematic eating behaviors

Effect of calcium channel blockers on the serum levels of thyroid hormone

Background: The effect of the calcium channel blockers on the cardiovascular system is implemented judiciously in different conditions related to cardiovascular system such as angina pectoris, hypertension, and in cardiac arrhythmias but the aspect that deals with the impact of blockade of calcium channels in other systems like endocrine system remains eclipsed. These effects generally go unnoticed and the present study was formulated to elucidate the serum T3, T4, TSH levels after administration of calcium channel blockers and to observe the resultant side effect on the endocrine glands, if any by this commonly used group of drugs.Methods: The study was conducted on male albino rabbits, they were divided in three groups of ten each and each group received one of the calcium channel blockers- Verapamil, Diltiazem and Nifedipine for three months. At the end of each month the serum T3, T4, TSH levels were evaluated by chemiluminisence.Results:It was found that on continuous daily administration of calcium channel blockers there was a gradual fall in levels of T3 and T4 with rise in TSH levels in comparison to the control value taken before initiating the drug therapy.Conclusion: These findings could have potential clinical implications and this study proposes the importance of blood thyroid hormone level follow up in the long-term calcium channel blocker therapy.