Intravitreal Fluocinolone Acetonide (ILUVIEN) Implant for the Treatment of Refractory Cystoid Macular Oedema After Retinal Detachment Repair

Cystoid macular oedema (CMO) is one of the most frequent postoperative macular complications to cause partial visual recovery after successful retinal detachment (RD) repair. Refractory CMO is difficult to treat and many strategies have been employed with varying degrees of success. We report for the first time the use of ILUVIEN implant to treat refractory CMO after successful RD repair. A 65-year-old female presented with right eye full-thickness macular hole and underwent pars plana vitrectomy, internal limiting membrane peeling and cryotherapy with gas tamponade with 12% C3F8. She subsequently developed right eye macula-on RD and proliferative vitreoretinopathy and required multiple procedures for successful retinal reattachment. Later, she developed CMO that responded to intravitreal triamcinolone injections and intravitreal dexamethasone 0.7-mg implants but recurrence of CMO continued to be a problem. After receiving ILUVIEN intravitreal implant, her visual acuity improved and CMO resolved without recurrence for 13 months. Refractory CMO after RD repair is difficult to treat and in a quarter of cases will not improve without treatment. Our case shows that a single ILUVIEN implant maintained anatomical dry fovea and improved vision. This also demonstrates that ILUVIEN is an effective management strategy to reduce the need for repeated treatments

Comparative Study of TiMn and TiAlV Alloys via the Nanoindentation Technique

There are two common categories of implants that are used in medical sciences, i.e., orthopedic and dental ones. In this study, dental implant materials are focused such as Ti6Al4V alloys that are used for the replacement of lost teeth due to their high strength and biocompatibility. However, they cause infections in nearby tissues due to elemental release (potentially Al and V). Thus, manganese is selected to be incorporated into the alloy since it is also present in the human body in the form of traces. Different sets of implants were produced, i.e., Ti5Mn and Ti10Mn (where 5 and 10 describe the percentage of Mn) by using the powder metallurgy technique. This was followed by characterization techniques, including X-ray fluorescence spectroscopy (XRF), X-ray diffractometer (XRD), optical microscope (OM), and nanoindenter. The very aim of this study is to compare the microstructural evolutions, density, and mechanical properties of reference alloys and the ones produced in this study. Results show the microstructure of Ti6Al4V consists of the alpha (α) and beta (β) phases, while Ti5Mn and Ti10Mn revealed the beta (β) phases. The Ti5Mn alloy showed excellent mechanical properties than that of the Ti6Al4V counterpart. Extensive discussion is presented in light of the observed results. The relative density of Ti5Mn alloy was found to be enhanced than that of reference alloy

Comparative Study of TiMn and TiAlV Alloys via the Nanoindentation Technique

There are two common categories of implants that are used in medical sciences, i.e., orthopedic and dental ones. In this study, dental implant materials are focused such as Ti6Al4V alloys that are used for the replacement of lost teeth due to their high strength and biocompatibility. However, they cause infections in nearby tissues due to elemental release (potentially Al and V). Thus, manganese is selected to be incorporated into the alloy since it is also present in the human body in the form of traces. Different sets of implants were produced, i.e., Ti5Mn and Ti10Mn (where 5 and 10 describe the percentage of Mn) by using the powder metallurgy technique. This was followed by characterization techniques, including X-ray fluorescence spectroscopy (XRF), X-ray diffractometer (XRD), optical microscope (OM), and nanoindenter. The very aim of this study is to compare the microstructural evolutions, density, and mechanical properties of reference alloys and the ones produced in this study. Results show the microstructure of Ti6Al4V consists of the alpha (α) and beta (β) phases, while Ti5Mn and Ti10Mn revealed the beta (β) phases. The Ti5Mn alloy showed excellent mechanical properties than that of the Ti6Al4V counterpart. Extensive discussion is presented in light of the observed results. The relative density of Ti5Mn alloy was found to be enhanced than that of reference alloy