Constraints on particle acceleration sites in the Crab Nebula from relativistic MHD simulations

The Crab Nebula is one of the most efficient accelerators in the Galaxy and the only galactic source showing direct evidence of PeV particles. In spite of this, the physical process behind such effective acceleration is still a deep mystery. While particle acceleration, at least at the highest energies, is commonly thought to occur at the pulsar wind termination shock, the properties of the upstream flow are thought to be non-uniform along the shock surface, and important constraints on the mechanism at work come from exact knowledge of where along this surface particles are being accelerated. Here we use axisymmetric relativistic MHD simulations to obtain constraints on the acceleration site(s) of particles of different energies in the Crab Nebula. Various scenarios are considered for the injection of particles responsible for synchrotron radiation in the different frequency bands, radio, optical and X-rays. The resulting emission properties are compared with available data on the multi wavelength time variability of the inner nebula. Our main result is that the X-ray emitting particles are accelerated in the equatorial region of the pulsar wind. Possible implications on the nature of the acceleration mechanism are discussed.Comment: 12 pages, 7 figures, 2 table

Simulated synchrotron and Inverse Compton emission from Pulsar Wind Nebulae

We present a complete set of diagnostic tools aimed at reproducing synthetic non-thermal (synchrotron and/or Inverse Compton, IC) emissivity, integrated flux energy, polarization and spectral index simulated maps in comparison to observations. The time dependent relativistic magnetohydrodynamic (RMHD) equations are solved with a shock capturing code together with the evolution of the maximum particles energy. Applications to Pulsar Wind Nebulae (PWNe) are shown.Comment: 3 pages, 7 figures, proceeding of the conference "40 Years of Pulsars ", 12-17 August 2007, Montreal, Canada, submitted to AI

Application of Graph Theory to the elaboration of personal genomic data for genealogical research

In this communication a representation of the links between DNA-relatives based on Graph Theory is applied to the analysis of personal genomic data to obtain genealogical information. The method is tested on both simulated and real data and its applicability to the field of genealogical research is discussed. We envisage the proposed approach as a valid tool for a streamlined application to the publicly available data generated by many online personal genomic companies. In this way, anonymized matrices of pairwise genome sharing counts can help to improve the retrieval of genetic relationships between customers who provide explicit consent to the treatment of their data

Unsupervised Vehicle Counting via Multiple Camera Domain Adaptation

Monitoring vehicle flows in cities is crucial to improve the urban environment and quality of life of citizens. Images are the best sensing modality to perceive and assess the flow of vehicles in large areas. Current technologies for vehicle counting in images hinge on large quantities of annotated data, preventing their scalability to city-scale as new cameras are added to the system. This is a recurrent problem when dealing with physical systems and a key research area in Machine Learning and AI. We propose and discuss a new methodology to design image-based vehicle density estimators with few labeled data via multiple camera domain adaptations.Comment: 1st International Workshop on New Foundations for Human-Centered AI (NeHuAI) at ECAI-202

The β3 adrenoceptor in proliferative retinopathies: "Cinderella" steps out of its family shadow

: In the retina, hypoxic condition leads to overgrowing leaky vessels resulting in altered metabolic supply that may cause impaired visual function. Hypoxia-inducible factor-1 (HIF-1) is a central regulator of the retinal response to hypoxia by activating the transcription of numerous target genes, including vascular endothelium growth factor, which acts as a major player in retinal angiogenesis. In the present review, oxygen urge by the retina and its oxygen sensing systems including HIF-1 are discussed in respect to the role of the beta-adrenergic receptors (β-ARs) and their pharmacologic manipulation in the vascular response to hypoxia. In the β-AR family, β1- and β2-AR have long been attracting attention because their pharmacology is intensely used for human health, while β3-AR, the third and last cloned receptor is no longer increasingly emerging as an attractive target for drug discovery. Here, β3-AR, a main character in several organs including the heart, the adipose tissue and the urinary bladder, but so far a supporting actor in the retina, has been thoroughly examined in respect to its function in retinal response to hypoxia. In particular, its oxygen dependence has been taken as a key indicator of β3-AR involvement in HIF-1-mediated responses to oxygen. Hence, the possibility of β3-AR transcription by HIF-1 has been discussed from early circumstantial evidence to the recent demonstration that β3-AR acts as a novel HIF-1 target gene by playing like a putative intermediary between oxygen levels and retinal vessel proliferation. Thus, targeting β3-AR may implement the therapeutic armamentarium against neovascular pathologies of the eye

On the magnetohydrodynamic modelling of the Crab nebula radio emission

In recent years, it has become a well-established paradigm that many aspects of the physics of Pulsar Wind Nebulae (PWNe) can be fully accounted for within a relativistic MHD description. Numerical simulations have proven extremely successful in reproducing the X-ray morphology of the Crab Nebula, down to very fine detail. Radio emission, instead, is currently one of the most obscure aspects of the physics of these objects, and one that holds important information about pulsar properties and their role as antimatter factories. Here we address the question of radio emission morphology and integrated spectrum from the Crab Nebula, by using for the first time an axisymmetric dynamical model with parameters chosen to best reproduce its X-ray morphology. Based on our findings we discuss constraints on the origin of the radio emitting particles.Comment: 8 pages, 5 figures, 1 tabl