Design, characterization and evaluation of a lab-made photoreactor: a first step towards standardized procedures in photocatalysis.

For the last ten years, photochemistry has known a renewal with the emergence of new photoredox approaches along with the development of new powerful artificial sources of light. However, the described procedures often lack information about the characteristics of the setups (wavelength, actual received light power, distance from the source) even when commercial apparatuses are used. This lacunar information hampers the development of standardized procedures which would guarantee the reproducibility of the reactions. With the objective of furnishing a standardized setup, a lab-made reactor was designed. The use of 3D-printing technology makes it easily accessible to most laboratories. Its characterization showed the critical effect of the environmental conditions upon the light power received and how crucial they are for reproducibility of photochemical reactions. At last, the setup was evaluated against experiments taken from recent literature

Cobalt-Catalyzed (Hetero)arylation of Saturated Cyclic Amines with Grignard Reagents

(Hetero)aryl substituted saturated cyclic amines are ubiquitous scaffolds in biologically active molecules. Metal-catalyzed cross-couplings between halogeno N-heterocycles and organometallic species are efficient and modular reactions to access these attractive scaffolds. An overview of our work concerning the cobalt-catalyzed arylation of iodo-substituted cyclic amines is presented

Beyond catalyst deactivation: cross-metathesis involving olefins containing N-heteroaromatics

Alkenes containing N-heteroaromatics are known to be poor partners in cross-metathesis reactions, probably due to catalyst deactivation caused by the presence of a nitrogen atom. However, some examples of ring-closing and cross-metathesis involving alkenes that incorporate N-heteroaromatics can be found in the literature. In addition, recent mechanistic studies have focused on the rationalization of nitrogen-induced catalysts deactivation. The purpose of this mini-review is to give a brief overview of successful metathesis reactions involving olefins containing N-heteroaromatics in order to delineate some guidelines for the use of these challenging substrates in metathesis reactions

Synthetic Strategy toward the C44–C65 Fragment of Mirabalin

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