815 research outputs found

    An exploration of the development of academic identity in a School of Education

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    This paper explores the complex processes involved in the self-construction of academic identity in a UK School of Education. Building on seminal literature in this field and drawing on the research of four academics, it begins by discussing teacher educators’ varying perceptions of the need to re-configure their identity to meet the expectations of a twenty-first-century higher education workforce. The article proposes the formation of this identity to be a dynamic, career-long process. Diverse scaffolds for the development process are proposed, including opportunities for new teacher educators to be apprenticed into an aca- demic role, the centrality of communities of practice and the importance of the 15 supported development of academic skills such as writing for publication.Peer reviewe

    The effect of Lactobacillus reuteri supplementation on anthropometric measurements, lung function and lung infections in a cystic fibrosis population in KwaZulu-Natal.

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    BACKGROUND: Cystic fibrosis (CF) patients grow poorly and tend to be malnourished. They frequently suffer from lung infections necessitating the repeated use of antibiotics. AIM: This study was conducted to determine whether supplementation with a probiotic Lactobacillus reuteri (L. reuteri) could reduce the incidence and duration of lung infections, and whether this would impact on their anthropometric data. The secondary purpose was to compare the nutritional status of the CF patients attending CF clinics in Kwazulu-Natal (KZN) with CF patients attending CF clinics in Cape Town (CT). METHODS: Twenty three CF patients 6-31 years of age from 2 CF clinics in Kwazulu-Natal started the study although only 16 patients completed it. The study was a randomized, double blind, placebo controlled crossover trial with six months on placebo and six months on probiotic. Weight, height, mid arm circumference (MAC), triceps skin fold thickness (TSF), forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) were measured, sputum collected and a symptom diary completed over the 12 month period. Anthropometric data of CF patients attending CF clinics in CT was obtained from the publication by Westwood & Saitowitz (1999). RESULTS: Compliance with taking the L. reuteri was poor. Most took only 50% of the required daily dose. Probiotic supplementation showed a slight (non significant) trend to improve FEV1 and FVC, while no significant difference could be seen in the number and duration of the lung infections. Sputum analysis showed a non significant trend towards the probiotic reducing the number of bacteria in the sputum. There was a significant reduction of symptoms for fever, running nose, sore throat and ear ache while on placebo. There was a significant increase in weight gained off probiotic compared to the probiotic period. The changes in height, weight for age (WFA) percentiles, height for age (HFA) percentiles, WFA and HFA Z-scores, percentage expected weight for age and percentage expected height for age all showed no difference whether on or off probiotic. Over half the CF children in the KZN clinics were underweight for their actual height compared to one third in the CT clinics with a higher number of subjects below the 5th percentile for MAC and TSF readings compared to CT. CONCLUSION: Due to a small sample size and poor compliance no firm conclusions could be drawn. However a slight (non significant) improvement could be seen in favour of the probiotic for FEV1, FVC, and sputum analysis. Although all other findings were not significantly different it would be of benefit to carry out further investigation with improved compliance with the probiotic to see if the parameters set out above could be improved. The KZN and CT CF groups were comparable and the nutritional status of CF patients on KZN was well below that of the CT CF clinics and further monitoring would need to be carried out.Thesis (M.Sc.)-University of KwaZulu-Natal, Pietermaritzburg, 2007

    Diffuse X-ray emission in spiral galaxies

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    We compare the soft diffuse X-ray emission from Chandra images of 12 nearby intermediate inclination spiral galaxies to the morphology seen in Halpha, molecular gas, and mid-infrared emission. We find that diffuse X-ray emission is often located along spiral arms in the outer parts of spiral galaxies but tends to be distributed in a rounder morphology in the center. The X-ray morphology in the spiral arms matches that seen in the mid-infrared or Halpha and so implies that the X-ray emission is associated with recent active star formation. We see no strong evidence for X-ray emission trailing the location of high mass star formation in spiral arms. However, population synthesis models predict a high mechanical energy output rate from supernovae for a time period that is about 10 times longer than the lifetime of massive ionizing stars, conflicting with the narrow appearance of the arms in X-rays. The fraction of supernova energy that goes into heating the ISM must depend on environment and is probably higher near sites of active star formation. The X-ray estimated emission measures suggest that the volume filling factors and scale heights are high in the galaxy centers but low in the outer parts of these galaxies. The differences between the X-ray properties and morphology in the centers and outer parts of these galaxies suggest that galactic fountains operate in outer galaxy disks but that winds are primarily driven from galaxy centers.Comment: 28 pages, 4 figures, to be submitted to Ap

    Convergent evolution of pregnancy-specific glycoproteins in human and horse

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    Pregnancy-specific glycoproteins (PSGs) are members of the carcinoembryonic antigen cell adhesion molecule (CEACAM) family that are secreted by trophoblast cells. PSGs may modulate immune, angiogenic and platelet responses during pregnancy. Until now, PSGs are only found in species that have a highly invasive (hemochorial) placentation including humans, mice and rats. Surprisingly, analyzing the CEACAM gene family of the horse, which has a non-invasive epitheliochorial placenta, with the exception of the transient endometrial cups, we identified equine CEACAM family members that seem to be related to PSGs of rodents and primates. We identified seven genes that encode secreted PSG-like CEACAMs. Phylogenetic analyses indicate that they evolved independently from an equine CEACAM1-like ancestor rather than from a common PSG-like ancestor with rodents and primates. Significantly, expression of PSG-like genes (CEACAM44, CEACAM48, CEACAM49 and CEACAM55) was found in non-invasive as well as invasive trophoblast cells such as purified chorionic girdle cells and endometrial cup cells. Chorionic girdle cells are highly invasive trophoblast cells that invade the endometrium of the mare where they form endometrial cups and are in close contact with maternal immune cells. Therefore, the microenvironment of invasive equine trophoblast cells has striking similarities to the microenvironment of trophoblast cells in hemochorial placentas, suggesting that equine PSG-like CEACAMs and rodent and primate PSGs have undergone convergent evolution. This is supported by our finding that equine PSG-like CEACAM49 exhibits similar activity to certain rodent and human PSGs in a functional assay of platelet–fibrinogen binding. Our results have implications for understanding the evolution of PSGs and their functions in maternal–fetal interactions

    Patterns of depredation in the Hawai‘i deep-set longline fishery informed by fishery and false killer whale behavior

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    False killer whales (Pseudorca crassidens) depredate bait and catch in the Hawai‘i-based deep-set longline fishery, and as a result, this species is hooked or entangled more than any other cetacean in this fishery. We analyzed data collected by fisheries observers and from satellite-linked transmitters deployed on false killer whales to identify patterns of odontocete depredation that could help fishermen avoid overlap with whales. Odontocete depredation was observed on ˜6% of deep-set hauls across the fleet from 2004 to 2018. Model outcomes from binomial GAMMs suggested coarse patterns, for example, higher rates of depredation in winter, at lower latitudes, and with higher fishing effort. However, explanatory power was low, and no covariates were identified that could be used in a predictive context. The best indicator of depredation was the occurrence of depredation on a previous set of the same vessel. We identified spatiotemporal scales of this repeat depredation to provide guidance to fishermen on how far to move or how long to wait to reduce the probability of repeated interactions. The risk of depredation decreased with both space and time from a previous occurrence, with the greatest benefits achieved by moving ˜400 km or waiting ˜9 d, which reduced the occurrence of depredation from 18% to 9% (a 50% reduction). Fishermen moved a median 46 km and waited 4.7 h following an observed depredation interaction, which our analysis suggests is unlikely to lead to large reductions in risk. Satellite-tagged pelagic false killer whales moved up to 75 km in 4 h and 335 km in 24 h, suggesting that they can likely keep pace with longline vessels for at least four hours and likely longer. We recommend fishermen avoid areas of known depredation or bycatch by moving as far and as quickly as practical, especially within a day or two of the depredation or bycatch event. We also encourage captains to communicate depredation and bycatch occurrence to enable other vessels to similarly avoid high-risk areas

    Strategies of exploitation of mammalian reservoirs by Bartonella species

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    Numerous mammal species, including domestic and wild animals such as ruminants, dogs, cats and rodents, as well as humans, serve as reservoir hosts for various Bartonella species. Some of those species that exploit non-human mammals as reservoir hosts have zoonotic potential. Our understanding of interactions between bartonellae and reservoir hosts has been greatly improved by the development of animal models for infection and the use of molecular tools allowing large scale mutagenesis of Bartonella species. By reviewing and combining the results of these and other approaches we can obtain a comprehensive insight into the molecular interactions that underlie the exploitation of reservoir hosts by Bartonella species, particularly the well-studied interactions with vascular endothelial cells and erythrocytes

    Overcoming Impediments to Shellfish Aquaculture through Legal Research and Outreach: Case Studies

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    More than half of the population of the continental United States resides in coastal communities, which are increasingly home to commercial shellfish aquaculture operations. Consequently, a variety of user conflicts can arise as states seek to encourage the development or expansion of shellfish aquaculture. Each of these conflicts creates the potential for opposition and legal challenges to the industry. An understanding of the legal and regulatory context governing shellfish aquaculture can assist in managing conflicts related to the industry. Laws and regulations in some cases create or can be perceived as impediments to the growth or success of the aquaculture industry. However, federal, state, and local legal frameworks reflect public policy choices about the multiple uses of submerged lands. Research and outreach focusing on the regulatory barriers to shellfish aquaculture can increase understanding of current legal structures and identify alternative policy options to more effectively manage submerged lands as well as the industry. In 2017, the National Sea Grant College Program funded a multi-institutional, national collaboration to examine legal impediments to shellfish aquaculture across the United States. This abstract has been adapted from the report\u27s introduction
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