New Construction of Functionalized CuO/Al2O3 Nanocomposite-Based Polymeric Sensor for Potentiometric Estimation of Naltrexone Hydrochloride in Commercial Formulations

Electrically conductive polymeric nanocomposites with nanoparticles are adaptable types of nanomaterials that are prospective for various applications. The extraordinary features of copper oxide (CuO) and aluminium oxide (Al2O3) nanostructures, encourages extensive studies to prospect these metal oxide nanocomposites as potential electroactive materials in sensing and biosensing applications. This study suggested a new CuO/Al2O3 nanocomposite-based polymeric coated wire membrane sensor for estimating naltrexone hydrochloride (NTX) in commercial formulations. Naltrexone hydrochloride and sodium tetraphenylborate (Na-TPB) were incorporated in the presence of polymeric polyvinyl chloride (PVC) and solvent mediator o-nitrophenyloctyl ether (o-NPOE) to form naltrexone tetraphenylborate (NTX-TPB) as an electroactive material. The modified sensor using NTX-TPB-CuO/Al2O3 nanocomposite displayed high selectivity and sensitivity for the discrimination and quantification of NTX with a linearity range 1.0 × 10−9–1.0 × 10−2 mol L−1 and a regression equation EmV = (58.25 ± 0.3) log [NTX] + 754.25. Contrarily, the unmodified coated wire sensor of NTX-TPB exhibited a Nernstian response at 1.0 × 10−5–1.0 × 10−2 mol L−1 and a regression equation EmV = (52.1 ± 0.2) log [NTX] + 406.6. The suggested modified potentiometric system was validated with respect to various criteria using the methodology recommended guidelines

Characterization by Potentiometric Procedures of the Stability Constants of the Binary and Ternary Complexes of Cu(II) and Duloxetine Drug with Amino Acids

Potentiometric titration method has been used to define stoichiometries and stability constants of ternary complexes of Cu(II) with duloxetine (D) and some selected amino acids (L). The protonation constants of the ligands and the stability constants of the binary and ternary complexes of Cu(II) with the ligands were calculated from the potentiometric data using the HYPERQUAD program. The formation constants of the complexes formed in aqueous solutions and their concentration distributions as a function of pH were evaluated at 25°C and ionic strength 0.10 mol·L−1 NaNO3. Respective stabilities of ternary complexes have been determined compared with the corresponding binary complexes in terms of Δlog  K and %R.S. values. A novel binary and ternary duloxetine (D) drug with glycine and its Cu(II) complexes has been synthesized and characterized by several spectroscopic methods. Electronic spectra and magnetic susceptibility measurements reveal square planar geometry for both complexes. The elemental analyses and mass spectral data have justified the [Cu(D)(Gly)] and [Cu(D)Cl(H2O)] composition of complexes, where D = duloxetine and Gly = glycine. The EPR spectra of Cu(II) complexes support the mononuclear structures. Thermal properties and decomposition kinetics of Cu(II) complexes are investigated

Fast and novel multiwalled carbon nanotubes decorated with metal oxide nanoparticles for potentiometric detection of a prohibited medication in sports acebutolol hydrochloride

A straightforward approach for creating fast and novel potentiometric sensors that are modified with multi-walled nanotubes (MWCNTs) was described. The impact of the selective sensor's material was studied. The suggested sensors were successfully fabricated for instant and fast detection of the prohibited β-adrenoreceptor blocking agent acebutolol hydrochloride (AC) in commercial products. Acebutolol-phosphomolybdate (AC-PM) carbon paste sensor was formed by mixing AC and phosphomolybdic acid and graphite powder in the presence of o-nitrophenyl octyl ether (o-NPOE) as a plasticizing agent. The functionalized AC-PM-MWCNTs and AC-PM-MWCNTs-Al2O3 nanocomposite sensors were prepared and all parameters affecting the sensors' potential responses have been investigated as well as the green synthesis of Al2O3NPs has been characterized using various microscopic and spectroscopic techniques. AC-PM-MWCNTs and AC-PM-MWCNTs-Al2O3 nanocomposite sensors demonstrated linearity of 1.0 × 10−7-1.0 × 10−2 and 1.0 × 10−8-1.0 × 10−2 mol L−1, respectively with regression equations −53.571x + 423.24 (r = 0.999) and −57.107x + 518.54 (r = 0.999). It also revealed excellent selectivity and sensitivity for the determination and quantification of AC. The developed potentiometric system was suitable for the determination of AC in bulk powder and commercial products

Assessment of essential elements and heavy metals in Saudi Arabian rice samples underwent various processing methods

Environmental, soil, and groundwater pollution from toxic heavy metals, as well as food safety are all global concerns nowadays. The effect of various processes viz. washing, soaking, and cooking of rice samples (ten rice varieties, 50 samples) on the concentration of essential elements and toxic heavy metals was determined using the inductively coupled plasma-mass spectrometry technique. The concentrations of As, Cd, Cu, and Ni were found to be below the maximum permissible levels. The range of mean concentrations of metals (mg/kg) was recorded as Al (15.495–8.151), Fe (10.358–7.499), Ni (0.399–0.176), Cu (4.518–2.615), Zn (28.635–12.880), As (0.152–0.042), Cd (0.233–0.038), Pb (0.713–0.417), Ti (2.157 > 0.521), Sn (1.406–0.016), and W (1.114–0.017) mg/kg. Pt and Ag metals were not found in all samples. Soaking rice for 2 h was one of the most successful techniques for lowering heavy metal concentrations, followed by overnight soaking, which aided in the elimination of Al, Cd, Pb, and Pb. Heavy metal exposure has a significant impact on human health. This study creates a promising view to use a simple and accurate detection method for minimizing the effect of different processing methods on the essential elements and heavy metal contents

Green biosynthesis of Fe3O4 nanoparticles using Chlorella vulgaris extract for enhancing degradation of 2,4 dinitrophenol

Objectives: This study aimed to provide the excellent role of Chlorella vulgaris extract as a green, reducing agent for improving and enhancing the effectiveness and performance of as-prepared NPs, which is higher than bare Fe3O4. Methods: The extract of the algal cell of Chlorella vulgaris is used as a green, reducing agent was used to prepare green Fe3O4 NPs to improve and enhance the degradation effectiveness of 2,4 dinitrophenol (2,4 DNP) in their aqueous solution using UV irradiation. The as-synthesized bare Fe3O4 and green Fe3O4 NPs were characterized using UV–VIS spectroscopy, TEM, SEM, EDX, XRD, and FT-IR spectroscopy to determine bandgap energy, particle size, structural morphology, crystallite nature, phase structure, elemental compositions, and existed functional group. Results: SEM and TEM images indicated that the as-synthesized NPs have a regular spherical shape with a mean size ranging between 13.68 and 31.71 nm. The energy bandgap (Eg) indicated the green Fe3O4 NPs have low values (2.73 and 2.3 eV) than bare Fe3O4 (2.89 eV). The maximum degradation of 2,4 DNP was achieved at pH = 8, 90 min contact time, 0.35 g/L catalyst dose, and 100 mg/L 2,4 DNP concentration. Conclusion: The degradation results proved that green Fe3O4 NPs have more effectiveness than bare Fe3O4 NPs

Ultrasensitive functionalized CeO2/ZnO nanocomposite sensor for determination of a prohibited narcotic in sports pethidine hydrochloride

The extraordinary features of cerium oxide (CeO2) and zinc oxide (ZnO) nanostructures have encouraged substantial attention to those nanocomposites as probable electroactive complexes for sensing and biosensing purposes. In this study, an advanced novel factionalized CeO2/ZnO nanocomposite-aluminum wire membrane sensor was designed to assess pethidine hydrochloride (PTD) in commercial injection samples. Pethidine-reineckate (PTD-RK) was formed by mixing pethidine hydrochloride and ammonium reineckate (ARK) in the presence of polymeric matrix (polyvinyl chloride) and o-nitrophenyl octyl ether as a fluidizing agent. The functionalized nanocomposite sensor displayed a fast dynamic response and wide linearity for the detection of PTD. It also revealed excellent selectivity and sensitivity, high accuracy, and precision for the determination and quantification of PTD when compared with the unmodified sensor PTD-RK. The guidelines of analytical methodology requirements were obeyed to improve the suitability and validity of the suggested potentiometric system according to several criteria. The developed potentiometric system was suitable for the determination of PTD in bulk powder and commercial products

Identification of Chemical Composition and Metal Determination of Retama raetam (Forssk) Stem Constituents Using ICP-MS, GC-MS-MS, and DART-MS

This study aims to investigate the chemical constituents of the stem of Retama raetam growing in Saudi Arabia. The organic and inorganic composition of ethanol extract of R. raetam stem has been explored using direct analysis in real time-mass spectrometry (DART-MS), gas chromatography-mass spectrometry (GC-MS), and inductively coupled plasma-mass spectrometry (ICP-MS). Analysis conducted by DART-MS and GC-MS reveals the presence of several interesting organic constituents identified as 2,4-di-tert-butylphenol, sparteine, benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, methyl ester, phthalic acid, 1-octadecanol, squalene, argentamin, 2,4-di-tert-butylphenol, sparteine, benzene propanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, methyl ester, phthalic acid, 1-octadecanol, squalene, argentamin, and hentriacontane in the ethanol extract of the R. raetam stem. The ICP-MS analysis of stem extract showed the presence of a significant amount of important inorganic elements including aluminum, chlorine, calcium, bromine magnesium, phosphorus, scandium, and chromium. The current study complements other R. raetam extract investigations carried out in the past and provides the additional data for the future research studies

New Construction of Functionalized CuO/Al₂O₃ Nanocomposite-Based Polymeric Sensor for Potentiometric Estimation of Naltrexone Hydrochloride in Commercial Formulations

Electrically conductive polymeric nanocomposites with nanoparticles are adaptable types of nanomaterials that are prospective for various applications. The extraordinary features of copper oxide (CuO) and aluminium oxide (Al2O3) nanostructures, encourages extensive studies to prospect these metal oxide nanocomposites as potential electroactive materials in sensing and biosensing applications. This study suggested a new CuO/Al2O3 nanocomposite-based polymeric coated wire membrane sensor for estimating naltrexone hydrochloride (NTX) in commercial formulations. Naltrexone hydrochloride and sodium tetraphenylborate (Na-TPB) were incorporated in the presence of polymeric polyvinyl chloride (PVC) and solvent mediator o-nitrophenyloctyl ether (o-NPOE) to form naltrexone tetraphenylborate (NTX-TPB) as an electroactive material. The modified sensor using NTX-TPB-CuO/Al2O3 nanocomposite displayed high selectivity and sensitivity for the discrimination and quantification of NTX with a linearity range 1.0 × 10−9–1.0 × 10−2 mol L−1 and a regression equation EmV = (58.25 ± 0.3) log [NTX] + 754.25. Contrarily, the unmodified coated wire sensor of NTX-TPB exhibited a Nernstian response at 1.0 × 10−5–1.0 × 10−2 mol L−1 and a regression equation EmV = (52.1 ± 0.2) log [NTX] + 406.6. The suggested modified potentiometric system was validated with respect to various criteria using the methodology recommended guidelines

Facile Synthesis, Characterization, Anti-Microbial and Anti-Oxidant Properties of Alkylamine Functionalized Dumb-Bell Shaped Copper-Silver Nanostructures

Admirable studies have been established on the utilization of ligand-materials as bimetallic nanoparticles in the field of nanoscience and biotechnology. UV-Vis, XRD, HR-TEM, STEM-HAADF, EDS, FTIR, and DPPH analyses characterized the optical, structural, compositional morphological, and antioxidant properties of synthesized Cu-Ag nanostructures. The spectrum of UV-Vis exhibited absorption bands at 590 and 413 nm, which reflects the surface plasmon resonance of copper-silver nanostructures. Herein, our exploration of alkylamine stabilized copper/silver nanostructures while using hexadecylamine as capping material and their primary biomedical investigation on antimicrobial and antioxidant studies is reported. Cu-Ag bimetallic nanostructures were more effective against gram-negative bacteria E. coli and Klebsiella when compared to gram-positive bacteria. The antioxidant activity of Cu-Ag nanoparticles was comparable with Ascorbic acid