Specific gut microbial, biological, and psychiatric profiling related to binge eating disorders: A cross-sectional study in obese patients

Background & aimsBinge eating disorder (BED) is a frequent eating disorder associated with obesity and co-morbidities including psychiatric pathologies, which represent a big health burden on the society.The biological processes related to BED remain unknown. Based on psychological testing, anthropometry, clinical biology, gut microbiota analysis and metabolomic assessment, we aimed to examine the complex biological and psychiatric profile of obese patients with and without BED.MethodsPsychological and biological characteristics (anthropometry, plasma biology, gut microbiota, blood pressure) of 101 obese subjects from the Food4Gut cohort were analysed to decipher the differences between BED and Non BED patients, classified based on the Questionnaire for Eating Disorder Diagnosis (Q-EDD). Microbial 16S rDNA sequencing and plasma non-targeted metabolomics (liquid chromatography-mass spectrometry) were performed in a subcohort of 91 and 39 patients respectively.ResultsBED subjects exhibited an impaired affect balance, deficits in inhibition and self-regulation together with marked alterations of eating behaviour (increased emotional and external eating). BED subjects displayed a lower blood pressure and hip circumference. A decrease in Akkermansia and Intestimonas as well as an increase in Bifidobacterium and Anaerostipes characterized BED subjects. Interestingly, metabolomics analysis revealed that BED subjects displayed a higher level of one food contaminants, Bisphenol A bis(2,3-dihydroxypropyl) ether (BADGE.2H(2)O) and a food derived-metabolite the Isovalerylcarnitine.ConclusionsNon-targeted omics approaches allow to select specific microbial genera and two plasma metabolites that characterize BED obese patients. Further studies are needed to confirm their potential role as drivers or biomarkers of binge eating disorder

Introduction: Outsourcing Versus Integration, a Key Trade-Off for Wine Companies?

While outsourcing is considered to be a basic principle of good management for modern companies, it is sparsely applied in the wine industry with respect to the core stage of winemaking, although it is likely to be used for peripheral activities. Given that the majority of wine estates are not loss-producing, the goal of this chapter is to study whether outsourcing or vertical integration of the wine companies is a factor of growth and profitability

Union renewal in France and Hyman's universal dualism

This paper draws upon the work of Richard Hyman to examine the question of union renewal in France. Developing a discussion around union renewal is particularly significant in the context of France, since studies on French unions since the mid-1980s have centred on the movement’s ‘decline’ and ‘crisis’, and France has rarely been included in comparative studies on union renewal and revitalisation. The paper uses empirical data collected from 2003-2010 to present a case study of SUD-Rail, a breakaway union formed in the French public railway sector in 1996 from an ideological split with one of France’s largest union confederations, the Confédération Française Démocratique du Travail (CFDT). SUD-Rail forms part of a wider set of SUD unions that have emerged since the late-1980s with the stated aim of revitalising French unionism by mobilising new collectivities and energising workplace union structures. This paper analyses the development of this movement over the last fifteen years, its attempts to renew and revitalise collective action and organisation, and explores the wider implications for union renewal in France. The paper argues that the development of SUD-Rail represents evidence of Hyman’s oft-mentioned tension in the identity of unions as both movements and organisations which has wider implications for understanding the possibilities and limitations of union action

Trade unions, politics and parties: is a new configuration possible?

Trade unions are not merely economic (or ‘industrial relations’) actors: they are necessarily protagonists in the political arena. Regulating the labour market is a question of power resources. Yet if unions are inescapably both economic and political actors, the relationship between the two roles is complex and contradictory, and the priority assigned to each varies across countries and over time. Four factors seem of particular importance in explaining these distinctive patterns: ideology, opportunity structures, organizational capacity and contextual challenges. We explore these issues with reference to ten west European countries, and end by pointing to some of the ideational and practical reasons why unions must explicitly redefine their political identities

Employee Representatives in France: Employers’ Perceptions and Expectations Towards Improved Industrial Relations

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