HAMILTON-JACOBI TREATMENT OF LAGRANGIANS WITHIN FRACTIONAL CAPUTO DERIVATIVES

In this work, the Hamilton-Jacobi formulation of fractional Caputo Lagrangians of linear velocities is investigated. The fractional Hamilton-Jacobi equations of motion for several potential systems are derived. Under certain conditions on the potential, it is shown that the action integral is independent on the fractional Caputo derivatives

Investigation into the prophylactic and therapeutic activity of coenzyme Q10 against COVID-19

Purpose: To evaluate the anti-SARS CoV-2 effect of Coenzyme Q 10, Ubiquinol-10, and idebenone, which have beneficial therapeutic applications against diverse virus types, using molecular docking approach.Methods: The potential activity of Coenzyme Q10, Ubiquinol-10, and Idebenone against viral infections was explored through the collection of data from relevant literature, and by modelling these compounds virtually, using in silico investigation methods.Results: Coenzyme Q10 and ubiquinol-10 showed significant docking performance. They interacted with numerous amino acid residues of the main protease of SARS-CoV-2 ACE2 (7C8J), Alpha thrombin (1AE8), TYRO (4TS1) protein targets sides, SARS-coronavirus Orf7a accessory protein (1XAK), TNF (1RJ8), and Cytokine/receptor (1I1R).Conclusion: The findings of our study showed promising inhibitory activities of the selected compounds against the main proteases of SARS-CoV-2. Consequently, these compounds have theoretical effects on inhibiting the viral entry, reproduction, and ultimately the prevention and/or treatment of the SARSCoV2 infection

Metabonomics as a clinical tool of analysis : LC-MS approaches

Metabolic differences between test and control groups (i.e. metabonomics) are routinely accomplished by using multivariate analysis for data obtained commonly from NMR, GC-MS and LC-MS. Multivariate analysis (e.g. principal component analysis PCA) is commonly used to extract potential metabolites responsible for clinical observations. Metabonomics applied to the clinical field is challenging because the physiological variabilities like gender, age, race…etc might govern the cluster pattern obtained by multivariate analysis instead of the tested differences. This review focuses on the challenges facing the clinical applications of metabonomics and introduces their possible solutions as mentioned in the literature

Microscopic trends in methanol/water and acetonitrile/water systems

Examination of some trends and differences between acetonitrile/water and methanol/water mixtures has been carried out. These systems are of interest for chromatographers since they are common mobile constituents. Some differences in the molecular arrangement of these solvents were observed from NMR and IR results. These observations might be of use in understanding and developing chromatographic separations. IR studies revealed C-H bond compression in methanol compared with acetonitrile which indicates different molecular arrangement in their aqueous mixtures. NMR and IR results show a clear non-linear behaviour in molecular arrangement. This justifies the deviation of methanol and acetonitrile aqueous solution from the norm. However, both solvents showed similar ionization suppression effects on examples of weak acids and bases

The Development and Application of Novel IR and NMR-Based Model for the Evaluation of Carminative Effect of Artemisia judaica L. Essential Oil

Artemisia judaica L. is a medicinal plant that is traditionally used to relieve abdominal pains through its carminative activity. In this study, spectroscopic analysis was employed to investigate the carminative activity associated with A. judaica. Using infrared spectroscopy, the carminative activity was evaluated based on the first derivative of IR-characteristic stretching signal of CO2. Our results indicate that A. judaica oil effectively reduced the response of CO2 signal equivalent to thymol standard. Additionally, 1H-NMR spectroscopy was utilized to assess surface activity of A. judaica crude oil through the reduction of interfacial tension in a D2O/CDCl3 system. Apparently, 10 mg of the oil was able to solubilize water in a chloroform layer up to 4.3% (w/w). In order to correlate the observed surface activity of the oil to its actual composition, GC-MS and GC-FID structural analysis were undertaken. The results revealed that the oil composition consists of oxygenated terpenes which might be responsible for the carminative effect. Furthermore, owing to its sensitivity, our model provides a fundamental basis for the pharmacological assessment of trace amounts of oils with high precision and accuracy

Stability determination for cyclized 2,4-dinitrophenyl hydrazone derivative of glucose

Abstract Background The most well established tactic for the analysis of monosaccharaides, such as glucose, relies on derivatization procedures, using reagents as 2,4-dinitrophenylhydrazine (DNPH). Usually, the instability of the formed imine product deteriorates the detection of trace amounts of the sugar; rendering the spectrophotometric analysis of monosaccharaides extremely challenging. Methods In this study, we propose a modified derivatization procedure, reliant on the formation of a stable DNPH-glucose derivative, to aid in the spectrophotometric analysis of glucose. The derivatization procedure was customized to perform the product work-up step under acidic conditions. Results The proton rich media resulted in direct reduction of the Schiff’s base with concomitant intramolecular rearrangement of the product to yield a stable cyclized DNPH-glucose derivative. The annealed structure of the titled compound was verified by 1NMR, 13C-NMR, HMBC and X-ray crystallography. Conclusions The derivative revealed extended stability in spiked plasma samples which suggests a potential to employ the described procedure for glucose analysis and detection in biological samples

7-(3-Chlorophenylamino)-1-cyclopropyl-6-fluoro-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid

7-(3-Chlorophenylamino)-1-cyclopropyl-6-fluoro-8-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid (2) was prepared and fully characterized by NMR, IR, and MS. Compound 2 exhibited good antibacterial activity against gram-positive standard and resistant strains