Sarcoma de Kaposi, importancia de su diagnóstico para un correcto tratamiento.

El Sarcoma de Kaposi es una neoplasia vascular poco frecuente, descrita por Moritz Kaposi en 1872.Se desarrolla comúnmente de las células endoteliales con evidencia de origen linfático también. Se han descrito 4 formas:• Clásica.• Endémica.• Asociada a iatrogenia por inmunosupresión.• Asociada a SIDA.Esta última tiene una incidencia de 70% en pacientes VIH+ siendo el paladar duro, la lengua y la encía los lugares con más frecuencia de aparición. En el 22% de los casos, la cavidad oral es el lugar de origen de esta lesión, causando movilidad dental, sangrado y dolor

Diversity of KIR/HLA Genotypes and Their Association with Psoriasis Vulgaris in the Western Mexican Population

NK and some T cell functions are regulated by the interaction between KIR and HLA molecules. Several studies have shown an association between activating KIR genes and the development of autoimmune diseases, including psoriasis vulgaris (PsV). Our objective was to determine the association between KIR/HLA genes and genotypes with PsV in the Western mestizo Mexican population. One hundred subjects diagnosed with PsV (SP) and 108 healthy subjects (HS) were genotyped for 14 KIR genes, HLA-Bw4, HLA-C1, and HLA-C2 by PCR-single specific primer (SSP). Positive associations of the KIR3DS1 gene (odds ratio (OR) 1.959, p = 0.021), G11 genotype (OR 19.940, p = 0.008), and KIR3DS1/HLA-ABw4 (OR 2.265, p = 0.009) were found with susceptibility to PsV. In contrast, the G1 genotype (OR 0.448, p = 0.031) and KIR3DL1/HLA-Bw4Ile80 (OR 0.522, p = 0.022) were negatively associated with susceptibility to this disease. These results suggest an implication of the KIR3DS1/HLA-ABw4 genotype in PsV pathology