The role of polymorphism of hereditary thrombophilia candidate genes in the development of arterial hypertension in women with preeclampsia

Preeclampsia is a severe pregnancy complication that has long been one of the leading causes of maternal and perinatal mortality and morbidity worldwide. Despite the achievements of modern medicine, the etiology of this pathology is not known. Multiple risk factors for the development of PE have been identified: arterial hypertension, diabetes mellitus, obesity, a hereditary history of preeclampsia, thrombophilia, etc., but recently, special attention has been paid to genetic determinants, namely, the contribution of individual polymorphic loci of various gene

The relationship between placental gene polymorphisms and preeclampsia risk in Russian women

To study the associations of polymorphisms of the NDRG1 gene, which is differentially expressed in the placenta, with the risk of preeclampsia (PE) development. The study group included 997 women: 366 pregnant women with preeclampsia and 631 women with physiological pregnancy. Clinical and laboratory examination of pregnant women was carried out in the Perinatal Center of the Belgorod Regional Clinical Hospital of St. Joasaph. DNA was isolated from peripheral venous blood lymphocytes by phenol-chloroform extraction. All women underwent typing of four single nucleotide polymorphisms of the N-myc downstream regulated gene 1 (NDRG1). The analysis of SNPs associations with the development of preeclampsia was performed using logistic regression analysis within the framework of additive, dominant and recessive genetic model