2 research outputs found
The Adverse Effects of Lead
- Author
- Altschuller LF
- Baloh R
- Baltrop D
- Barker DJP
- Barker DJP
- Barker DJP
- Barltop D
- Beattie AD
- Bellinger D
- Bendick A
- Blakey BR
- Blumer W
- Borgman RF
- Boutron CF
- Bryce-Smith D
- Bryce-Smith D
- Bryce-Smith D
- Bryce-Smith D
- Bryce-Smith D
- Bryce-Smith D
- Bryce-Smith D
- Cambell AMG
- Canterow A
- Carlsen E
- Carpenter SJ
- Chisholm JJ
- Chisholm JJ
- Clayton BE
- Danielson L
- David O
- David O
- David OJ
- Davie R
- Davies S
- Davis MJ
- Day JP
- De la Burde B
- De la Burde B
- Dietrich KN
- Erhart CB
- Exon JH
- Faith RE
- Gainer HJ
- Gallagher A
- Gershanik J
- Gilfillan SC
- Gloag D
- Gordan GF
- Goyer RA
- Goyer RA
- Guiet-Bara A
- Hales CN
- Hansen JC
- Harlan WR
- Healy MA
- Heasman MA
- Hebel JR
- Hepple P
- Hernberg S
- Hess K
- Hicks RM
- Hilbum ME
- Houk VN
- Hricko A
- Illingsworth RS
- Jacobziner H
- Johnson NE
- Kang HK
- Khera AK
- Knelson JH
- Koller LD
- Kostial K
- Kotok D
- Laker M
- Landrigan PG
- Landrigan PJ
- Landsdowne RG
- Lin-Fu JS
- Lin-Fu JS
- Lin-Fu JS
- Lockeretz W
- Luster MI
- Mahaffey KR
- Mahaffey KR
- Maugh TH
- Mills CA
- Moore MR
- Moore Mr
- Moore MR
- Moore MR
- Needleman HL
- Needleman HL
- Needleman HL
- Needleman HL
- Needleman HL
- Neilman BA
- Nicklowitz WJ
- Nielsen T
- Ong CN
- Patterson CC
- Perino J
- Phil RO
- Piomelli S
- Pirkle J
- Rajegowda BK
- Rom W
- Rosen JF
- Russell-Jones R
- Sayre JW
- Schauss A
- Schroeder HA
- Schwartz J
- Shapiro IM
- Simpson JM
- Smith M
- Sohler A
- Spivey-Fox MR
- Staesson JA
- Stehlow CD
- Stephens R
- Stilbergeld EK
- Stoch MB
- Stock MV
- Tatcher RW
- Ter Haar G
- Tuormaa TE
- Underwod EJ
- Ward NI
- Ward NI
- Whincup PH
- Wibberley DG
- Winick M
- Wynn M
- Yule W
- Zarkowsky H
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Ezetimibe added to statin therapy after acute coronary syndromes
- Author
- Aagnes I
- Aambakk MB
- Aase O
- Aaser E
- Abdel-Latief A
- Abell T
- Aboufakher R
- Abramson B
- Abrantes J
- Achilli A
- Adams A
- Adams K
- Adamus J
- Addington J
- Adgey A
- Adjei A
- Agarwal J
- Aggarwal A
- Aggarwal K
- Aggarwal R
- Agocha A
- Agraou B
- Aguirre O
- Ahmed A
- Ahmed O
- Ahsan A
- Airaksinen J
- Airoldi F
- Aji J
- Akkad H
- Akubzanova E
- Al-Ani R
- Al-Jumaily J
- Alameda J
- Albirini A
- Albuquerque A
- Albuquerque D
- Alcasena S
- Alexander J
- Alfonso F
- Ali MI
- Alings MA
- Allall O
- Allen J
- Allen RP
- Allred S
- Almeira AS
- Alonso L
- Alsagheer S
- Alshaher M
- Altschuller A
- Alvarez J
- Alvarez J
- Alvarez Y
- Alves A
- Amidon T
- Amos M
- Anaszewicz M
- Andersen M
- Andersen O
- Andersson E
- Andersson G
- Andrade G
- Andrade M
- Andrea B
- Andreou C
- Antonangelo A
- Antorrena I
- Appel K
- Arana C
- Aranda M
- Araujo J
- Arce R
- Ardito RV
- Ardito W
- Arend C
- Arias V
- Armada E
- Armstrong P
- Arnold A
- Arnold M
- Arntsen BI
- Arora P
- Aros F
- Arriagada G
- Arriagada G
- Artaecheverria J
- Arvesen K
- Arvigo L
- Ash Y
- Aske R
- Ata N
- Atar D
- Atar S
- Atassi K
- Atieh M
- Atkinson C
- Atzenhofer-Baumgartner K
- Auer J
- Aug L
- Ausen K
- Aycock G
- Aylward P
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- Azize G
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- Azzolini P
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- Badings EA
- Baeza N
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- Baiz A
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- Banikova A
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- Bugos V
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- Buss I
- Bustamante G
- Butcher R
- Butkus E
- Butter C
- Buzetti C
- Byfuglien A
- Cabrera-Santamaria A
- CalderĂłn MJ
- Calic S
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- Calpar I
- Calzolari D
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- Cannon C
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- Cannon Christopher P.
- Canto J
- Cappelen H
- Capucci A
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- Clemmensen P
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- da Cunha C
- Dagefoerde N
- Dahiya R
- Dalby A
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- Dale H
- Daley P
- Dalin L
- Dambrine P
- Damiano M
- Damiano S
- Damm T
- Dani S
- Daniel D
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- Danse IY
- Darcel I
- Darius H
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- Darnell Z
- Dauber I
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- Davidovits S
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- De Caterina R
- De Clippel M
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- De Ferrari G
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- de la Guia F
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- de Lemos J
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- Uziel-Iunger K
- Vahala P
- Vahdat O
- Vakaliuk I
- Valenzuela C
- Valpas S
- Van 't Hof A
- van Boven AJ
- van Dam C
- van de Borne P
- Van de Loo A
- Van de Werf F
- Van de Werf F
- Van Den Berg BJ
- Van Den Broeck D
- van der Bij P
- van der Sluis A
- van der Ven-Elzebroek N
- van der Weerdt A
- van der Zeijst M
- van der Zwaan C
- Van Dorpe A
- Van Dorpe A
- van Eck M
- van Es RF
- Van Hal JM
- van Hessen MW
- Van Kalmthout PM
- van Kempen LH
- Van Kieu C
- van Lennep HW
- van Loo LW
- Van Miert N
- van Nes E
- van Rossum P
- van Ruijven I
- Van Vlies B
- Van Zyl L
- Vanhauwaert B
- VanNatta B
- Vantomme C
- Varela P
- Varghese T
- Varma S
- Varner C
- Varroud-Vial N
- Vasiliauskas T
- Vazan A
- Vazquez A
- Veenstra W
- Vegsundvaag J
- Vejvoda J
- Velasquez D
- Velasquez J
- Veldmeijer S
- Velle H
- Venn-Edmonds C
- Vercauteren S
- Vertes G
- Vervoort G
- Veselka J
- Vestager KM
- Vetrano A
- Vicari R
- Vicente C
- Vicentini A
- Vichi V
- Viergever EP
- Vijay N
- Villa A
- Villa E
- Villa F
- Villani G
- Visconti L
- Viso M
- Vitovec J
- Vizel S
- Vlastaris A
- Vogel C
- Voitk J
- Voitk J
- Voitk J
- Volpe M
- vom Dahl J
- Von Bakonyi A
- Vora K
- Voss J
- Voutilainen S
- Voyles W
- Vykoukalova T
- VĂ©rtes A
- Waage K
- Waalewijn RA
- Wainstein M
- Waldo D
- Walsh S
- Walters B
- Wang Y
- Wanitschek M
- Ward P
- Ward U
- Warlits B
- Warnica J
- Washam M
- Watkins K
- Watson R
- Wead J
- Wechselberger T
- Weeks A
- Weidinger F
- Weihs W
- Weil J
- Weiss A
- Weller C
- Werner G
- Werter CJ
- Wertheimer J
- Wesley D
- Westecott B
- Westenburg J
- Wheeler M
- Wheeler M
- Whitaker T
- Whitcomb C
- White D
- White H
- White H
- White J
- White J
- White J
- White Jennifer A.
- Wiegman P
- Wiemer M
- Wikström P
- Wilhelm J
- Wilhelm M
- Wilks J
- Willems FF
- Williams P
- Williams S
- Williams V
- Wilson S
- Wilson V
- Wilson V
- Winestock J
- Winther-Friis B
- Wirtemburg P
- Wiseman A
- Withagen AJ
- Witsaman S
- Witt N
- Witzling V
- Wiviott Stephen D.
- Wohns D
- Wojciechowska C
- Wong A
- Wong B
- Wong G
- Wong S
- Wong Y
- Woodhead G
- Worner F
- Worthley S
- Wright L
- Wright T
- Wright W
- Wrzosek B
- Wu C
- Wu L
- Wu W
- Wyman P
- Yalcin R
- Yanez L
- Yedinak S
- Yeh H
- Yen M
- Yeo D
- Yigit Z
- Yildirir A
- Yildiz Z
- Yoon J
- Yoon M
- Young C
- Yovaniniz P
- Yu C
- Yu W
- Yuval R
- Zahn R
- Zakhary B
- Zaluska R
- Zambahari R
- Zanini R
- Zanini R
- Zanolin D
- Zapata M
- Zarandon R
- Zeiher A
- Zeltser D
- Zeman K
- Zemberova A
- Zemour G
- Zender H
- Zeymer U
- Zhukova Y
- Ziegler B
- Zimlichman R
- Zimmerman T
- Zimmermann R
- Zingarelli A
- Zirkle J
- Zucchetti C
- Zughaib M
- Zuidgeest JA
- Zuppiroli A
- Zwart PA
- Zweiker R
- Ă…ngman K
- Édes I
- Ă–stberg S
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2015
- Field of study
BACKGROUND: Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known. METHODS: We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to 100 mg per deciliter (1.3 to 2.6 mmol per liter) if they were receiving lipid-lowering therapy or 50 to 125 mg per deciliter (1.3 to 3.2 mmol per liter) if they were not receiving lipid-lowering therapy. The combination of simvastatin (40 mg) and ezetimibe (10 mg) (simvastatin-ezetimibe) was compared with simvastatin (40 mg) and placebo (simvastatin monotherapy). The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina requiring rehospitalization, coronary revascularization ( 6530 days after randomization), or nonfatal stroke. The median follow-up was 6 years. RESULTS: The median time-weighted average LDL cholesterol level during the study was 53.7 mg per deciliter (1.4 mmol per liter) in the simvastatin-ezetimibe group, as compared with 69.5 mg per deciliter (1.8 mmol per liter) in the simvastatin-monotherapy group (P<0.001). The Kaplan-Meier event rate for the primary end point at 7 years was 32.7% in the simvastatin-ezetimibe group, as compared with 34.7% in the simvastatin-monotherapy group (absolute risk difference, 2.0 percentage points; hazard ratio, 0.936; 95% confidence interval, 0.89 to 0.99; P = 0.016). Rates of pre-specified muscle, gallbladder, and hepatic adverse effects and cancer were similar in the two groups. CONCLUSIONS: When added to statin therapy, ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes. Moreover, lowering LDL cholesterol to levels below previous targets provided additional benefit