The East Midlands in 2010: sub-regional profiles

The East Midlands in 2010 is the updated evidence base that supports the regional economic strategy, A Flourishing Region. This document presents detailed analysis of the East Midlands' sub-regions.

The East Midlands in 2010: deprivation and economic inclusion

The East Midlands in 2010 is the updated evidence base that supports the regional economic strategy, A Flourishing Region. This document presents detailed analysis of deprivation and economic inclusion in the East Midlands

The East Midlands in 2010

The East Midlands in 2010 is the updated evidence base that supports the regional economic strategy, A Flourishing Region. It presents a statistical portrait of the region covering demography, housing, economy & productivity, the labour market, deprivation & economic inclusion, transport, infrastructure & development, the environment and the spatial structure of the economy along with a series of sub-regional profiles

East Midlands skills priorities statement academic year 2011-2012

The East Midlands Skills Priorities Statement sets out the skills required to support economic growth and recovery in the region. The statement presents priorities for the academic year 2011-2012 for skills at all levels for those aged 16 and above. It is based on the latest labour market intelligence and information on provision and includes prospects to 2017

East Midlands skills priorities statement academic year 2011-2012 annex 3: evidence base for the east midlands skills priorities statement

The East Midlands Skills Priorities Statement sets out the skills required to support economic growth and recovery in the region. The statement presents priorities for the academic year 2011-2012 for skills at all levels for those aged 16 and above. It is based on the latest labour market intelligence and information on provision and includes prospects to 2017. Annex 3 contains detailed supporting analysis

The East Midlands in 2010: labour market

The East Midlands in 2010 is the updated evidence base that supports the regional economic strategy, A Flourishing Region. This document presents detailed analysis of the labour market in the East Midlands

Dysregulation of ß-catenin, WISP1 and TCF21 predicts disease-specific survival and primary response against radio(chemo)therapy in patients with locally advanced squamous cell carcinomas of the head and neck

Objective: The objective of this study was to determine the prognostic and predictive impact of β-catenin, TCF21 and WISP1 expression in patients with squamous cell carcinomas of the head and neck who underwent primary radiotherapy or concomitant chemoradiotherapy. Study design: Prospective cohort study. Setting: University hospital. Participants: Protein expression profiles of β-catenin, TCF21, WISP1 and p16 were determined by immunohistochemical analyses in tissue samples of 59 untreated patients. Expression was correlated with different outcome parameters. Main outcome measures: Impact of TNM classification, grading, sex, age, gender, type of therapy, response to therapy and p16 status on disease-specific (DSS) and disease-free survival (DFS). Results: Patients with high expression of TCF21 were associated with significantly worse disease-specific survival (P = 0.005). In a multivariable analysis, TCF21 was a significant determinant of disease-specific survival. (HR 3.01; P = 0.036). Conversely, low expression of β-catenin (P = 0.025) and WISP1 (P = 0.037) revealed a better response to radiotherapy. Conclusion: Since data show that TCF21 is a prognostic factor for disease-specific survival and WISP1 and ß-catenin are predictive factors for clinical outcome after definitive radiotherapy, further studies are warranted to prove these preliminary but very promising findings. © 2019 John Wiley & Sons Lt

Availability and use of rapid diagnostic tests for the management of acute childhood infections in Europe: A cross-sectional survey of paediatricians

BACKGROUND: Point-of-care-tests (POCTs) have been advocated to optimise care in patients with infections but their actual use varies. This study aimed to estimate the variability in the adoption of current POCTs by paediatricians across Europe, and to explore the determinants of variability. METHODS AND FINDINGS: A cross-sectional survey was conducted of hospital and primary care paediatricians, recruited through professional networks. Questions focused on the availability and use of currently available POCTs. Data were analysed descriptively and using Median Odds Ratio (MOR) to measure variation between countries. Multilevel regression modelling using changes in the area under the receiver operating characteristic curve of models were used to assess the contribution of individual or workplace versus country level factors, to the observed variation. The commonest POCT was urine dipsticks (UD) which were available to >80% of primary care and hospital paediatricians in 68% (13/19) and 79% (23/29) countries, respectively. Availability of all POCTs varied between countries. In primary care, the country (MOR) varied from 1.61 (95%CI: 1.04-2.58) for lactate to 7.28 (95%CI: 3.04-24.35) for UD. In hospitals, the country MOR varied from 1.37 (95%CI:1.04-1.80) for lactate to 11.93 (95%CI:3.35-72.23) for UD. Most paediatricians in primary care (69%, 795/1154) and hospital (81%, 962/1188) would use a diagnostic test in the case scenario of an infant with undifferentiated fever. Multilevel regression modelling showed that the country of work was more important in predicting both the availability and use of POCTs than individual or workplace characteristics. CONCLUSION: There is substantial variability in the adoption of POCTs for the management of acute infections in children across Europe. To inform future implementation of both existing and innovative tests, further research is needed to understand what drives the variation between countries, the needs of frontline clinicians, and the role of diagnostic tests in the management of acute childhood infections