The Advantages of Lateral Tarsal Strip Procedure

No Abstract: Commentar

The XMM-Newton Slew Survey

XMM-Newton, with the huge collecting area of its mirrors and the high quantum efficiency of its EPIC detectors, is the most sensitive X-ray observatory ever flown. This is strikingly evident during slew exposures, which, while yielding only at most 14 seconds of on-source exposure time, actually constitute a 2-10 keV survey ten times deeper than all other "all-sky" surveys. The current (April 2005) XMM archive contains 374 slew exposures which give a uniform coverage over around 10,000 square degrees (approx. 25% of the sky). Here we describe the results of pilot studies, the current status of the XMM-Newton Slew Survey, up-to-date results and our progress towards constructing a catalogue of slew detections in the full 0.2-12 keV energy band.Comment: 3 pages, 4 figures, XMM-Newton EPIC Consortium Meeting, Schloss Ringberg, Germany, April 2005, to appear in MPE Repor

Extended sources in the XMM-Newton slew survey

The low background, good spatial resolution and great sensitivity of the EPIC-pn camera on XMM-Newton give useful limits for the detection of extended sources even during the short exposures made during slewing maneouvers. In this paper we attempt to illustrate the potential of the XMM-Newton slew survey as a tool for analysing flux-limited samples of clusters of galaxies and other sources of spatially extended X-ray emission.Comment: 2 pages, 4 figures, to appear in the proceedings of "The X-ray Universe 2005", San Lorenzo de El Escorial (Spain), 26-30 September 200

The XMM-Newton Slew Survey: towards the XMMSL1 catalogue

The XMM-Newton satellite is the most sensitive X-ray observatory flown to date due to the great collecting area of its mirrors coupled with the high quantum efficiency of the EPIC detectors. It performs slewing manoeuvers between observation targets tracking almost circular orbits through the ecliptic poles due to the Sun constraint. Slews are made with the EPIC cameras open and the other instruments closed, operating with the observing mode set to the one of the previous pointed observation and the medium filter in place. Slew observations from the EPIC-pn camera in FF, eFF and LW modes provide data, resulting in a maximum of 15 seconds of on-source time. These data can be used to give a uniform survey of the X-ray sky, at great sensitivity in the hard band compared with other X-ray all-sky surveys.Comment: 2 pages, 2 figures, to appear in the proceedings of "The X-ray Universe 2005", San Lorenzo de El Escorial (Spain), 26-30 September 200

Chandra and optical/IR observations of CXOJ1415.2+3610, a massive, newly discovered galaxy cluster at z~1.5

(Abridged) We report the discovery of CXO J1415.2+3610, a distant (z~1.5) galaxy cluster serendipitously detected in a deep, high-resolution Chandra observation targeted to study the cluster WARP J1415.1+3612 at z=1.03. This is the highest-z cluster discovered with Chandra so far. Moreover, the total exposure time of 280 ks with ACIS-S provides the deepest X-ray observation currently achieved on a cluster at z>1.5. We perform an X-ray spectral fit of the extended emission of the intracluster medium (ICM) with XSPEC, and we detect at a 99.5% confidence level the rest frame 6.7-6.9 keV Iron K_\alpha line complex, from which we obtain z_X=1.46\pm0.025. The analysis of the z-3.6\mu m color-magnitude diagram shows a well defined sequence of red galaxies within 1' from the cluster X-ray emission peak with a color range [5 < z-3.6 \mu m < 6]. The photometric redshift obtained by spectral energy distribution (SED) fitting is z_phot=1.47\pm 0.25. After fixing the redshift to z=1.46, we perform the final spectral analysis and measure the average gas temperature with a 20% error, kT=5.8^{+1.2}_{-1.0} keV, and the Fe abundance Z_Fe = 1.3_{-0.5}^{+0.8}Z_\odot. We fit the background subtracted surface brightness with a single beta--model out to 35" and derive the deprojected electron density profile. The ICM mass is 1.09_{-0.2}^{+0.3}\times 10^{13} M_\odot within 300 kpc. The total mass is M_{2500}= 8.6_{-1.7}^{+2.1} \times 10 ^{13} M_\odot for R_{2500}=(220\pm 55) kpc. Extrapolating the profile at larger radii we find M_{500}= 2.1_{-0.5}^{+0.7} \times 10 ^{14} M_\odot for R_{500} = 510_{-50}^{+55}$ kpc. This analysis establishes CXOJ1415.2+3610 as one of the best characterized distant galaxy clusters based on X-ray data alone.Comment: 12 pages, 9 figures, A\&A in press, minor modifications in the tex

STAT3, a hub protein of cellular signaling pathways, is triggered by β-hexaclorocyclohexane

Background: Organochlorine pesticides (OCPs) are widely distributed in the environment and their toxicity is mostly associated with the molecular mechanisms of endocrine disruption. Among OCPs, particular attention was focused on the effects of β-hexaclorocyclohexane (β-HCH), a widely common pollutant. A detailed epidemiological study carried out on exposed population in the “Valle del Sacco” found correlations between the incidence of a wide range of diseases and the occurrence of β-HCH contamination. Taking into account the pleiotropic role of the protein signal transducer and activator of transcription 3 (STAT3), its function as a hub protein in cellular signaling pathways triggered by β-HCH was investigated in different cell lines corresponding to tissues that are especially vulnerable to damage by environmental pollutants. Materials and Methods: Human prostate cancer (LNCaP), human breast cancer (MCF-7 and MDA-MB 468), and human hepatoma (HepG2) cell lines were treated with 10 µM β-HCH in the presence or absence of specific inhibitors for different receptors. All samples were subjected to analysis by immunoblotting and RT-qPCR. Results and Conclusions: The preliminary results allow us to hypothesize the involvement of STAT3, through both its canonical and non-canonical pathways, in response to β-HCH. Moreover, we ascertained the role of STAT3 as a master regulator of energy metabolism via the altered expression and localization of HIF-1α and PKM2, respectively, resulting in a Warburg-like effect

Physical Properties of OSIRIS-REx Target Asteroid (101955) 1999 RQ36 derived from Herschel, ESO-VISIR and Spitzer observations

In September 2011, the Herschel Space Observatory performed an observation campaign with the PACS photometer observing the asteroid (101955) 1999 RQ36 in the far infrared. The Herschel observations were analysed, together with ESO VLT-VISIR and Spitzer-IRS data, by means of a thermophysical model in order to derive the physical properties of 1999 RQ36. We find the asteroid has an effective diameter in the range 480 to 511 m, a slightly elongated shape with a semi-major axis ratio of a/b=1.04, a geometric albedo of 0.045 +0.015/-0.012, and a retrograde rotation with a spin vector between -70 and -90 deg ecliptic latitude. The thermal emission at wavelengths below 12 micron -originating in the hot sub-solar region- shows that there may be large variations in roughness on the surface along the equatorial zone of 1999 RQ36, but further measurements are required for final proof. We determine that the asteroid has a disk-averaged thermal inertia of Gamma = 650 Jm-2s-0.5K-1 with a 3-sigma confidence range of 350 to 950 Jm-2s-0.5K-1, equivalent to what is observed for 25143 Itokawa and suggestive that 1999 RQ36 has a similar surface texture and may also be a rubble-pile in nature. The low albedo indicates that 1999 RQ36 very likely contains primitive volatile-rich material, consistent with its spectral type, and that it is an ideal target for the OSIRIS-REx sample return mission.Comment: Accepted for publication in Astronomy & Astrophysics, 9 pages, 7 figure

Short-term effects of focal muscle vibration on motor recovery after acute stroke: a pilot randomized sham-controlled study

Repetitive focal muscle vibration (rMV) is known to promote neural plasticity and long-lasting motor recovery in chronic stroke patients. Those structural and functional changes within the motor network underlying motor recovery occur in the very first hours after stroke. Nonetheless, to our knowledge, no rMV-based studies have been carried out in acute stroke patients so far, and the clinical benefit of rMV in this phase of stroke is yet to be determined. The aim of this randomized double-blind sham-controlled study is to investigate the short-term effect of rMV on motor recovery in acute stroke patients. Out of 22 acute stroke patients, 10 were treated with the rMV (vibration group–VG), while 12 underwent the sham treatment (control group–CG). Both treatments were carried out for 3 consecutive days, starting within 72 h of stroke onset; each daily session consisted of three 10-min treatments (for each treated limb), interspersed with a 1-min interval. rMV was delivered using a specific device (Cro®System, NEMOCO srl, Italy). The transducer was applied perpendicular to the target muscle's belly, near its distal tendon insertion, generating a 0.2–0.5 mm peak-to-peak sinusoidal displacement at a frequency of 100 Hz. All participants also underwent a daily standard rehabilitation program. The study protocol underwent local ethics committee approval (ClinicalTrial.gov NCT03697525) and written informed consent was obtained from all of the participants. With regard to the different pre-treatment clinical statuses, VG patients showed significant clinical improvement with respect to CG-treated patients among the NIHSS (p &lt; 0.001), Fugl-Meyer (p = 0.001), and Motricity Index (p &lt; 0.001) scores. In addition, when the upper and lower limb scales scores were compared between the two groups, VG patients were found to have a better clinical improvement at all the clinical end points. This study provides the first evidence that rMV is able to improve the motor outcome in a cohort of acute stroke patients, regardless of the pretreatment clinical status. Being a safe and well-tolerated intervention, which is easy to perform at the bedside, rMV may represent a valid complementary non-pharmacological therapy to promote motor recovery in acute stroke patients

Cytokine-regulated expression of survivin in myeloid leukemia

: Survivin, a member of the inhibitors-of-apoptosis gene family, is expressed in a cell-cycle-dependent manner in all the most common cancers but not in normal differentiated adult tissues. Survivin expression and regulation were examined in acute myeloid leukemia (AML). Survivin was detected by Western blot analysis in all myeloid leukemia cell lines and in 16 of 18 primary AML samples tested. In contrast, normal CD34(+) cells and normal peripheral blood mononuclear cells expressed no or very low levels of survivin. Cytokine stimulation increased survivin expression in leukemic cell lines and in primary AML samples. In cultured primary samples, single-cytokine stimulation substantially increased survivin expression in comparison with control cells, and the combination of G-CSF, GM-CSF, and SCF increased survivin levels even further. Conversely, all-trans retinoic acid significantly decreased survivin protein levels in HL-60, OCI-AML3, and NB-4 cells within 96 hours, parallel to the induction of myelomonocytic differentiation. Using selective pharmacologic inhibitors, the differential involvement of mitogen-activated protein kinase kinase (MEK) and phosphatidylinositol-3 kinase (PI3K) pathways were demonstrated in the regulation of survivin expression. The MEK inhibitor PD98059 down-regulated survivin expression in both resting and GM-CSF-stimulated OCI-AML3 cells, whereas the PI3K inhibitor LY294002 inhibited survivin expression only on GM-CSF stimulation. In conclusion, these results demonstrate that survivin is highly expressed and cytokine-regulated in myeloid leukemias and suggest that hematopoietic cytokines exert their antiapoptotic and mitogenic effects, at least in part, by increasing survivin levels