Accuracy of intraoperative consultation in the evaluation of salivary gland tumors

[No abstract available]sem informação5116sem informaçãosem informaçãoWenig, B.M., (2008) Atlas of Head and Neck Pathology, , 2nd ed. Philadelphia: ElsevierGnepp, D.R., (2009) Diagnostic Surgical Pathology of the Head and Neck, , 2nd ed. Amsterdam: ElsevierMcHugh, J.B., Visscher, D.W., Barnes, E.L., Update on selected salivary gland neoplasms (2009) Arch Pathol Lab Med., 133 (11), pp. 1763-1774Heller, K.S., Attie, J.N., Dubner, S., Accuracy of frozen section in the evaluation of salivary tumors (1993) Am J Surg., 166 (4), pp. 424-427Seethala, R.R., LiVolsi, V.A., Baloch, Z.W., Relative accuracy of fine-needle aspiration and frozen section in the diagnosis of lesions of the parotid gland (2005) Head Neck., 27 (3), pp. 217-223Fonseca, T.C., Eisenberg, A.L.A., Accuracy of intraoperative consultation in lesions of the salivary glands: Analysis of 748 cases (2015) J Bras Patol Med Lab., 51 (1), pp. 52-5

Enhancement of the convective cooling of two heaters in a rectangular duct by impinging jets

A numerical investigation was performed to compare two alternative configurations for the convective air cooling of two heaters flush mounted on the lower horizontal wall of a rectangular duct. One configuration consisted of duct flow with uniform airflow velocity and temperature at the duct inlet and the heaters were located in the flow entrance region. In the other, the cooling was obtained by impinging air jets exiting with uniform velocity and temperature from two square holes on the upper duct wall just above the heaters. The simulations were performed under steady state conditions considering the three dimensional flow region of each configuration, where the conservation equations were solved. The results were presented in the form of the adiabatic Nusselt number and a dimensionless pressure drop for both configurations, in the range of the duct Reynolds number from 500 to 9,00013148COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESNão te

New cytotoxic dammarane type saponins from Ziziphus spina-christi

Cancer is the world's second-leading cause of death. Drug development efforts frequently focus on medicinal plants since they are a valuable source of anticancer medications. A phytochemical investigation of the edible Ziziphus spina-christi (F. Rhamnaceae) leaf extract afforded two new dammarane type saponins identified as christinin E and F (1, 2), along with the known compound christinin A (3). Different cancer cell lines, such as lung cancer (A549), glioblastoma (U87), breast cancer (MDA-MB-231), and colorectal carcinoma (CT-26) cell lines, were used to investigate the extracted compounds' cytotoxic properties. Our findings showed significant effects on all the tested cell lines at varying concentrations (1, 5, 10, and 20 µg/mL). The three compounds exhibited potent activity at low concentrations (&lt; 10 μg/mL), as evidenced by their low IC50 values. To further investigate the complex relationships between these identified cancer-relevant biological targets and to identify critical targets in the pathogenesis of the disease, we turned to network pharmacology and in silico-based investigations. Following this, in silico-based analysis (e.g., inverse docking, ΔG calculation, and molecular dynamics simulation) was performed on the structures of the isolated compounds to identify additional potential targets for these compounds and their likely interactions with various signalling pathways relevant to this disease. Based on our findings, Z. spina-christi's compounds showed promise as potential anti-cancer therapeutic leads in the future.</p

Genomic profile of a squamous cell carcinoma Ex pleomorphic adenoma compared to a head and neck squamous cell carcinoma

[No abstract available]sem informação843393397FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO2011/23204-5; 2011/23366-

Nucleolar Organizer Region (nors) In Pseudocarcinomatous Hyperplasia And Squamous Cell Carcinoma Of The Oral Mucosa.

Counts of nucleolar regions (NORs) demonstrated by a silver staining technique in paraffin sections, have been used to distinguish benign from malignant lesions. AgNORs were studied in 24 biopsies from oral cavity (5 cases of normal oral mucosa, 5 of pseudocarcinomatous hyperplasia and 14 of squamous cell carcinoma, subdivided according to degree of differentiation: 5 grade 1, 5 grade 2 and 4 grade 3) to find whether they were helpful in distinguishing pseudocarcinomatous hyperplasia due to chronic parasitic infections from squamous cell carcinoma. Two methods of counting AgNORs were used: (A) a simpler one which counts nucleolar clusters (AgNU) and satellite AgNORs and the other (B) counting all individual AgNORs, including those within AgNUs. In both methods the lowest mean values were observed for grade 3 carcinoma, while the highest belonged to grade 2 carcinoma. The simpler method (A) was the most useful because AgNU counts showed significant difference when pseudocarcinomatous hyperplasia was compared with grade 1 and 2 carcinomas, which are the most difficult to discriminate from it. However the overlapping of values render the technique of limited use in individual cases.113169369