Flipping pharmacoepidemiology classes in a Saudi Doctor of Pharmacy program

Purpose: To examine student perceptions towards the flipped classroom approach and its impact on their learning and their course evaluation  when compared to the traditional classroom method.Methods: Five classes of the pharmacoepidemiology course were delivered using the flipped classroom approach. Student perception towards the flipped teaching method was measured using a satisfaction survey. Measuring the impact of the flipped classroom on student learning and the  student course evaluation was achieved by comparing the midterm grades and the results of the standard endof- course evaluations with the previous semester's cohort.Results: Students’ perceptions of the flipped classroom were mostly favourable. The course and its various components were viewed more favourably in the second semester than in the first semester. Statistically significant improvements were observed in the perception of the topics covered in the course (p = 0.045), fairness of the grade assessment (p = 0.004), and perception of course feedback (p = 0.021). No statistical  difference was noted between the midterm examination scores of the first semester cohort (24.53 ± 3.80) and the second semester cohort (25.15 ± 3.00); [t (22.54) = 0.53, p =0.3].Conclusion: This study demonstrates that using the flipped classroom approach for teaching pharmacoepidemiology can improve student satisfaction, as well as maintain their academic performance. Keywords: Flipped classroom, Pharmacy education, Blended learnin

Antiproliferative and anticancer activities of Neurada procumbens L. against epithelial carcinoma and breast cancer cell lines

308-314Neurada procumbens L. commonly called as sand button, is used as a medicinal herb by Bedouin in the Arabia Peninsula for heart and respiratory functions. This little known plant has not been investigated in detail for its biological activities. Hence, we have made an attempt to investigate the plant for its anticancer activities. Methanol and chloroform extracts of N.procumbens were evaluated for antiproliferative and anticancer activities in HEp-2 and MCF-7 cancer cell lines. Humanforeskin epithelial cells showed an IC50 value of 34 μg and 149 μg for chloroform and methanol extracts, respectively. Thechloroform extract of N. procumbens @3 μg showed 50% reduction of HEp-2 cell population in 24 h, while 5.5 μg showedsimilar effects in MCF-7 cells. The results of the methanol extracts were little varied, where 49 μg showed slow inhibitionof HEp-2 cells over a period of 72 h. In another similar observation, 76 μg of methanol extract inhibited 50% MCF-7 cellproliferation. The concentrations which could inhibit complete turnover of the experimental cancer cell lines at 24 h were>5 μg and 6 μg of chloroform extract and > 60 μg and 80 μg of methanol extract for HEp-2 and MCF-7, respectively. Themicro therapeutic index of methanol extract in HEp-2 and MCF-7 were 3 and 1.9, while chloroform extract was 11.3 and6.1. This is an initial observation of N. procumbens that shows antiproliferative activities against cancer cell lines

Cucurbitacin D exhibits potent anticancer activity in cervical cancer

In this study, we for the first time, investigated the potential anti-cancer effects of a novel analogue of cucurbitacin (Cucurbitacin D) against cervical cancer in vitro and in vivo. Cucurbitacin D inhibited viability and growth of cervical cancer cells (CaSki and SiHa) in a dose-dependent manner. IC50 of Cucurbitacin D was recorded at 400 nM and 250 nM in CaSki and SiHa cells, respectively. Induction of apoptosis was observed in Cucurbitacin D treated cervical cancer cells as measured by enhanced Annexin V staining and cleavage in PARP protein. Cucurbitacin D treatment of cervical cancer cells arrested the cell cycle in G1/S phase, inhibited constitutive expression of E6, Cyclin D1, CDK4, pRb, and Rb and induced the protein levels of p21 and p27. Cucurbitacin D also inhibited phosphorylation of STAT3 at Ser727 and Tyr705 residues as well as its downstream target genes c-Myc, and MMP9. Cucurbitacin D enhanced the expression of tumor suppressor microRNAs (miR-145, miRNA-143, and miRNA34a) in cervical cancer cells. Cucurbitacin D treatment (1 mg/kg body weight) effectively inhibited growth of cervical cancer cells derived orthotopic xenograft tumors in athymic nude mice. These results demonstrate the potential therapeutic efficacy of Cucurbitacin D against cervical cancer

Bioactive brominated oxindole alkaloids from the Red Sea sponge Callyspongia siphonella

In the present study, LC-HRESIMS-assisted dereplication along with bioactivity-guided isolation led to targeting two brominated oxindole alkaloids (compounds 1 and 2) which probably play a key role in the previously reported antibacterial, antibiofilm, and cytotoxicity of Callyspongia siphonella crude extracts. Both metabolites showed potent antibacterial activity against Gram-positive bacteria, Staphylococcus aureus (minimum inhibitory concentration (MIC) = 8 and 4 µg/mL) and Bacillus subtilis (MIC = 16 and 4 µg/mL), respectively. Furthermore, they displayed moderate biofilm inhibitory activity in Pseudomonas aeruginosa (49.32% and 41.76% inhibition, respectively), and moderate in vitro antitrypanosomal activity (13.47 and 10.27 µM, respectively). In addition, they revealed a strong cytotoxic effect toward different human cancer cell lines, supposedly through induction of necrosis. This study sheds light on the possible role of these metabolites (compounds 1 and 2) in keeping fouling organisms away from the sponge outer surface, and the possible applications of these defensive molecules in the development of new anti-infective agents

Academic Help-Seeking Behaviours of Undergraduate Pharmacy Students in Saudi Arabia: Usage and Helpfulness of Resources

Background: University students usually find it difficult to handle academic challenges by themselves and tend to seek help. Academic help seeking is defined as “a behavioral strategy that involves controlling one’s behavior and interacting socially to obtain help from other people.” Methods: A cross-sectional design was planned. An online self-administered questionnaire was used to collect data on academic help-seeking behaviours among year 5 undergraduate pharmacy students. Demographic and background information was described in terms of frequency. Their reasons for seeking academic help (five items) and factors considered for choosing academic resources (six items) used a Likert scale ranging from one (strongly disagree) to five (strongly agree). Usefulness (ten items) was rated on a five-point scale ranging from ‘very useful’ to ‘not useful at all.’ Frequency (ten items) was rated on a five-point scale ranging from ‘never’ to ‘every day.’ Results: A total of 116 pharmacy students completed the survey. The study indicated that the key reasons for seeking help were positive factors—a further improvement of one’s learning and the desire to complete a course. The resources that were most frequently used were peers, the course online portal, and online educational resources. The resources that students found most helpful were peers, the course instructor, textbooks, and online resources. Discussion and conclusion: The frequency of using a certain support resource was not mirrored by its helpfulness. Resources, including professors, teaching assistants, and textbooks, were found helpful but not frequently consulted for help. On the other hand, summaries and notes, for example, were frequently used but not particularly helpful. However, peers currently taking the course and the course management system were found to be very useful and frequently used

Using Design Thinking Method in Academic Advising: A Case Study in a College of Pharmacy in Saudi Arabia

Purpose: The current study was conducted to evaluate academic advising services in a pharmacy college in Saudi Arabia. This will result in developing solutions to overcome the identified challenges. Methods: Design thinking method uses five steps: empathising, defining, ideating, prototypes and testing. Results: Several issues were identified with students: limited awareness of academic rules and regulations; work-family life imbalance; lack of trust in academic advising and emotional support; unfamiliarity with different learning strategies; and lack of social life at the university. Discussion and conclusion: This study provides a model for enhancing students’ experiences with academic advising. It suggested several prototypes that have proven to be effective in enhancing students’ experiences in university life and how to overcome challenges. The prototypes include a peer academic advising club, personal development workshop and a series of lectures on college rules and regulations

COVID-19 Vaccine Hesitancy among Young Adults in Saudi Arabia: A Cross-Sectional Web-Based Study

Ending the COVID-19 pandemic requires achieving herd immunity, either by previous infection or by vaccination. However, concerns about the COVID-19 vaccine are growing around the globe. The current study was conducted to investigate young the adult population’s hesitancy towards the vaccine. The study used a prospective cross-sectional design. Data was collected using an online self-administered questionnaire. A total of 862 Saudi adults participated. Information was gathered on the participants’ perspectives towards the severity and susceptibility of the COVID-19 infection, reasons for their hesitancy to receive the vaccine, perceived benefits, and reasons for action. Just under a quarter (19.6%) of respondents had previously tested positive for COVID-19. A small minority of the participants had already received the vaccine (2.1%), while 20.3% had registered in the Sehaty app (application) to receive the vaccine. Just under half of them (48%) will take the vaccine when mass vaccination is achieved and approximately the same number (46.7%) will only take it if it is made mandatory. Vaccine reluctance is highly prevalent among the general public in Saudi Arabia during the COVID-19 pandemic. While many are aware of a high likelihood of getting the infection, the efficacy and safety of the COVID-19 vaccine were reported as barriers to vaccination

Pharmacological and Clinical Efficacy of Picrorhiza kurroa and Its Secondary Metabolites: A Comprehensive Review

Traditional remedies for the treatment of various ailments are gaining popularity. Traditionally, one of the most valuable therapeutic herbs has been Picrorhiza kurroa Royle ex Benth. Traditional and folk uses of P. kurroa include chronic constipation, skin-related problems, burning sensation, chronic reoccurring fever, jaundice, heart problems, breathing, digestion, allergy, tuberculosis, blood-related problems, prediabetes and obesity, laxative, cholagogue, and liver stimulatory. Phytoconstituents such as glycosides, alkaloids, cucurbitacins, iridoids, phenolics, and terpenes in P. kurroa have shown promising pharmacological potential. In order to uncover novel compounds that may cure chronic illnesses, such as cardiovascular, diabetes, cancer, respiratory, and hepatoprotective diseases, the screening of P. kurroa is essential. This study comprehensively evaluated the ethnopharmacological efficacy, phytochemistry, pharmacological activity, dose, and toxicity of P. kurroa. This review provides comprehensive insights into this traditional medication for future research and therapeutic application. The purpose of this review article was to determine the pharmacological effects of P. kurroa on a variety of disorders. P. kurroa may be a natural alternative to the standard treatment for eradicating newly evolving diseases. This study is intended as a resource for future fundamental and clinical investigations

Patients’ Satisfaction with E-Prescribing (Wasfaty) in Saudi Arabia: A Survey of Country-Level Implementation

Aim: This study was conducted to assess patient satisfaction with the e-prescription service implemented by the Ministry of Health hospitals and primary healthcare centres in Saudi Arabia. Methods: The study used a cross-sectional approach. Data were collected using a random sampling technique, and an online questionnaire was distributed among the study population. A five-point Likert scale, ranging from 1 (not at all satisfied) to 5 (very satisfied), was used to assess patient satisfaction. Results and Conclusions: A total of 400 patients participated in the study. More than half (57.5%) of them were males, and approximately one-third were between the ages of 30 and 39. Aspects related to the pharmacy, i.e., accessibility of pharmacies in terms of numbers, location, and opening hours, as well as pharmacy facilities, including waiting area, counselling area, dispensing area and parking lots, were skewed towards 5 (very satisfied). Aspects related to pharmacy personnel, i.e., knowledge, skills, and competencies, as well as friendliness and approachability, were also skewed towards 5 (very satisfied). Factors related to patient experience with Wasfaty, the new service, as compared with old primary healthcare centres’ pharmaceutical services, such as the availability of pharmacists, procedures for refills, waiting time, privacy, and confidentiality, were also skewed towards 5 (very satisfied)

Adopting global tools for the advancement of pharmacy practice and workforce in Saudi Arabia

Background: The continuing expansion of the pharmacist’s role necessitates continuous evaluation of current practice to identify strategies for improvements. The International Pharmaceutical Federation (FIP) has developed tools to support stakeholders in identifying development needs and planning advancement strategies. The aim of this research was to utilise the FIP Global Competency Framework, version 2 (GbCF v2), and FIP Development Goals (DGs) to evaluate competencies related to pharmacy practice in Saudi Arabia, and to understand the strategies needed to develop and improve the current practice. Methods: The study involved four phases. Phase 1 involved translation of the FIP GbCF v2 into the Arabic language. Phase 2 was a consensus panel validation to establish the initial relevance of the competencies to current practice. Phase 3 included a national survey distributed to all registered pharmacists in Saudi Arabia. The final phase was conducted through mapping ‘not relevant’ competencies to FIP DGs to identify priorities. Results: The translation phase yielded a bilingual framework that could be utilized by pharmacists in Saudi Arabia. The initial validation phase identified 61 behavioral statements (from 124 in the GbCF v2) as ‘highly relevant’ or ‘relevant’ to pharmacy practice. Findings from the national survey identified a list of ‘not relevant’ competencies that could highlight gaps in current practice. The final mapping phase generated a list of three FIP DG priorities: DG5 (competency development), DG8 (working with others) and DG11 (impact and outcomes). Conclusion: The study indicated that competencies in the GbCF v2 were relevant to pharmacists practicing in the country. However, some competencies were perceived as ‘not relevant’ to current practice and these highlighted gaps in the current practice that need attention. Mapping ‘not relevant’ competencies to FIP DGs should be used as a starting point towards developing strategies, systems, and protocols to advance pharmacy practice in Saudi Arabia