289 research outputs found
Terra e rendite nei secoli XII-XIII: Normandia, Inghliterra, Terrasanta.
Land and revenue in the Twelfth and Thirteenth Century: Normandy, England, the
Holy Land
Thanks to the documentation made available by the “Patrologia Latina” database, the author has managed to reconstruct the legal-institutional profile of the concessions ad firmam and their socio-economic contexts from the twelfth to the thirteenth centuries in Normandy, England, and the Holy Land. These agrarian contracts
have usually escaped scholarly attention and are intriguing for their connection with
the contractus censualis and the census reservativus, a legal institution present
throughout the modern age and which played an important role in the revolutionaryn.
M e d i t e r r a n e a R i c e r c h e s t o r i c h e Anno VII - Aprile 201
Hypoxia and angiogenic biomarkers in prostate cancer after external beam radiotherapy (EBRT) alone or combined with high-dose-rate brachytherapy boost (HDR-BTb)
Nab: Measurement Principles, Apparatus and Uncertainties
The Nab collaboration will perform a precise measurement of 'a', the
electron-neutrino correlation parameter, and 'b', the Fierz interference term
in neutron beta decay, in the Fundamental Neutron Physics Beamline at the SNS,
using a novel electric/magnetic field spectrometer and detector design. The
experiment is aiming at the 10^{-3} accuracy level in (Delta a)/a, and will
provide an independent measurement of lambda = G_A/G_V, the ratio of
axial-vector to vector coupling constants of the nucleon. Nab also plans to
perform the first ever measurement of 'b' in neutron decay, which will provide
an independent limit on the tensor weak coupling.Comment: 12 pages, 6 figures, 1 table, talk presented at the International
Workshop on Particle Physics with Slow Neutrons, Grenoble, 29-31 May 2008; to
appear in Nucl. Instrum. Meth. in Physics Research
Neutron Beta Decay Studies with Nab
Precision measurements in neutron beta decay serve to determine the coupling
constants of beta decay and allow for several stringent tests of the standard
model. This paper discusses the design and the expected performance of the Nab
spectrometer.Comment: Submitted to Proceedings of the Conference CIPANP12, St.Petersburg,
Florida, May 201
Heart failure in a woman with SLE, anti-phospholipid syndrome and Fabry's disease
We describe a female patient with systemic lupus erythematosus (SLE) also diagnosed with Fabry’s disease and anti-phospholipid antibody syndrome (APS). SLE and Fabry’s disease are both systemic diseases with variable clinical presentations. Recent studies have shown a relatively high incidence of late onset Fabry’s disease in female heterozygous individuals, suggesting that this condition could be under-diagnosed. We discuss a possible association between SLE and Fabry’s disease and consider the role of lipid abnormalities in the pathogenesis of SLE
PEN experiment: a precise measurement of the pi+ -> e+ nu decay branching fraction
A new measurement of , the decay
branching ratio, is currently under way at the Paul Scherrer Institute. The
present experimental result on constitutes the most accurate test
of lepton universality available. The accuracy, however, still lags behind the
theoretical precision by over an order of magnitude. Because of the large
helicity suppression of the decay, its branching ratio is
susceptible to significant contributions from new physics, making this decay a
particularly suitable subject of study.Comment: 4 pages, 3 figures, talk given at the Tenth Conference on the
Intersections of Particle and Nuclear Physics (CIPANP 2009), La Jolla/San
Diego, CA, 26-31 May 2009; to appear in Proceedings to be published by the
American Institute of Physic
PEN: a low energy test of lepton universality
Allowed charged meson decays are characterized by simple dynamics, few
available decay channels, mainly into leptons, and extremely well controlled
radiative and loop corrections. In that sense, pion decays represent a
veritable triumph of the standard model (SM) of elementary particles and
interactions. This relative theoretical simplicity makes charged pion decays a
sensitive means for testing the underlying symmetries and the universality of
weak fermion couplings, as well as for studying pion structure and chiral
dynamics. Even after considerable recent improvements, experimental precision
is lagging far behind that of the theoretical description for pion decays. We
review the current state of experimental study of the pion electronic decay
, or , where the
indicates inclusion and explicit treatment of radiative decay events. We
briefly review the limits on non-SM processes arising from the present level of
experimental precision in decays. Focusing on the PEN
experiment at the Paul Scherrer Institute (PSI), Switzerland, we examine the
prospects for further improvement in the near term.Comment: 11 pages, 5 figures; paper presented at the XIII International
Conference on Heavy Quarks and Leptons, 22-27 May 2016, Blacksburg, Virginia,
US
Spike-in SILAC proteomic approach reveals the vitronectin as an early molecular signature of liver fibrosis in hepatitis C infections with hepatic iron overload
Hepatitis C virus (HCV)-induced iron overload has been shown to promote liver fibrosis, steatosis, and hepatocellular carcinoma. The zonal-restricted histological distribution of pathological iron deposits has hampered the attempt to perform large-scale in vivo molecular investigations on the comorbidity between iron and HCV. Diagnostic and prognostic markers are not yet available to assess iron overload-induced liver fibrogenesis and progression in HCV infections. Here, by means of Spike-in SILAC proteomic approach, we first unveiled a specific membrane protein expression signature of HCV cell cultures in the presence of iron overload. Computational analysis of proteomic dataset highlighted the hepatocytic vitronectin expression as the most promising specific biomarker for iron-associated fibrogenesis in HCV infections. Next, the robustness of our in vitro findings was challenged in human liver biopsies by immunohistochemistry and yielded two major results: (i) hepatocytic vitronectin expression is associated to liver fibrogenesis in HCV-infected patients with iron overload; (ii) hepatic vitronectin expression was found to discriminate also the transition between mild to moderate fibrosis in HCV-infected patients without iron overload. \uc2\ua9 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Spike-in SILAC proteomic approach reveals the vitronectin as an early molecular signature of liver fibrosis in hepatitis C infections with hepatic iron overload
Hepatitis C virus (HCV)-induced iron overload has been shown to promote liver fibrosis, steatosis, and hepatocellular carcinoma. The zonal-restricted histological distribution of pathological iron deposits has hampered the attempt to perform large-scale in vivo molecular investigations on the comorbidity between iron and HCV. Diagnostic and prognostic markers are not yet available to assess iron overload-induced liver fibrogenesis and progression in HCV infections. Here, by means of Spike-in SILAC proteomic approach, we first unveiled a specific membrane protein expression signature of HCV cell cultures in the presence of iron overload. Computational analysis of proteomic dataset highlighted the hepatocytic vitronectin expression as the most promising specific biomarker for iron-associated fibrogenesis in HCV infections. Next, the robustness of our in vitro findings was challenged in human liver biopsies by immunohistochemistry and yielded two major results: (i) hepatocytic vitronectin expression is associated to liver fibrogenesis in HCV-infected patients with iron overload; (ii) hepatic vitronectin expression was found to discriminate also the transition between mild to moderate fibrosis in HCV-infected patients without iron overload. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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