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Séptimo desafío por la erradicación de la violencia contra las mujeres del Institut Universitari d’Estudis Feministes i de Gènere "Purificación Escribano" de la Universitat Jaume

El sistema del IGF-1 en el carpín : ritmicidad, regulación por factores ambientales y efecto sincronizador en el sistema circadiano

Tesis inédita de la Universidad Complutense de Madrid, Facultad de Ciencias Biológicas, leída el 24-03-2023El factor de crecimiento insulínico de tipo 1 (IGF-1) es una hormona implicada en múltiples procesos fisiológicos, cuya actividad está regulada por su unión a receptores específicos (IGF-1Rs) y a proteínas de unión (IGFBPs), constituyendo el denominado sistema del IGF-1. Este sistema debe sincronizarse temporalmente para asegurar su anticipación a los cambios cíclicos del ambiente, lo que es posible gracias al funcionamiento del sistema circadiano. La organización funcional del sistema circadiano en los vertebrados consiste en una red de osciladores cuya maquinaria molecular se basa en bucles de retroalimentación de los genes reloj y sus productos proteicos. El objetivo general de la presente Tesis Doctoral es el análisis de las variaciones diarias del sistema del IGF-1 en osciladores del carpín y su dependencia de sincronizadores ambientales; así como el estudio del papel del IGF-1 en la comunicación funcional entre osciladores circadianos...Insulin-like growth factor 1 (IGF-1) is a hormone that participates in several physiological processes. Its actions are regulated by its binding to both specific receptors (IGF-1Rs) and binding proteins (IGFBPs) that together with the IGF-1 constitutes the IGF-1 signaling system. This system should be synchronized to anticipate cyclic environmental changes, in a functional dependence of the circadian system. The functional organization of the circadian system in vertebrates consists on networks of oscillators based on feedbacks loops of the clock genes and their proteins.The overall objective of this PhD Thesis is to analyze the possible daily variations of the IGF-1 system in oscillators of goldfish, and their dependence on environmental synchronizers. In addition, the role of the IGF-1 in the functional communication among circadian oscillators is investigated...Fac. de Ciencias BiológicasTRUEunpu

Daily Rhythms in the IGF-1 System in the Liver of Goldfish and Their Synchronization to Light/Dark Cycle and Feeding Time

The relevance of the insulin-like growth factor-1 (IGF-1) system in several physiological processes is well-known in vertebrates, although little information about their temporal organization is available. This work aims to investigate the possible rhythmicity of the different components of the IGF-1 system (igf-1, the igf1ra and igf1rb receptors and the paralogs of its binding proteins IGFBP1 and IGFBP2) in the liver of goldfish. In addition, we also study the influence of two environmental cues, the light/dark cycle and feeding time, as zeitgebers. The hepatic igf-1 expression showed a significant daily rhythm with the acrophase prior to feeding time, which seems to be strongly dependent on both zeitgebers. Only igfbp1a-b and igfbp1b-b paralogs exhibited a robust daily rhythm of expression in the liver that persists in fish held under constant darkness or randomly fed. The hepatic expression of the two receptor subtypes did not show daily rhythms in any of the experimental conditions. Altogether these results point to the igf-1, igfbp1a-b, and igfbp1b-b as clock-controlled genes, supporting their role as putative rhythmic outputs of the hepatic oscillator, and highlight the relevance of mealtime as an external cue for the 24-h rhythmic expression of the IGF-1 system in fish

Gene characterization of nocturnin paralogues in goldfish: full coding sequences, structure, phylogeny and tissue expression

The aim of this work is the full characterization of all the nocturnin (noc) paralogues expressed in a teleost, the goldfish. An in silico analysis of the evolutive origin of noc in Osteichthyes is performed, including the splicing variants and new paralogues appearing after teleostean 3R genomic duplication and the cyprinine 4Rc. After sequencing the full-length mRNA of goldfish, we obtained two isoforms for noc-a (noc-aa and noc-ab) with two splice variants (I and II), and only one for noc-b (noc-bb) with two transcripts (II and III). Using the splicing variant II, the prediction of the secondary and tertiary structures renders a well-conserved 3D distribution of four α-helices and nine β-sheets in the three noc isoforms. A synteny analysis based on the localization of noc genes in the patrilineal or matrilineal subgenomes and a phylogenetic tree of protein sequences were accomplished to stablish a classification and a long-lasting nomenclature of noc in goldfish, and valid to be extrapolated to allotetraploid Cyprininae. Finally, both goldfish and zebrafish showed a broad tissue expression of all the noc paralogues. Moreover, the enriched expression of specific paralogues in some tissues argues in favour of neo- or subfunctionalization.Ministerio de Ciencia, Innovación y Universidades (España)Universidad Complutense de MadridDepto. de Genética, Fisiología y MicrobiologíaFac. de Ciencias BiológicasTRUEpubDescuento UC

Influence of the Mentor Competence on the Mentee Satisfaction: Mediation and Moderation

Mentee satisfaction is a common dependant variable, and it is commonly used to justify mentoring programs. Additionally, mentor competency is one of the main characteristics that constitutes a good mentor, it is a relevant aspect to be considered in the selection of the mentors, and in the training offered before the mentoring relationship starts. We analyzed mentoring in university settings, measuring mentor competency, mentee satisfaction, mentor trust, perceptions based on the role, and session content in a sample of 7245 mentor-mentee pairs after mentoring sessions were held. Regression analysis showed the influence of mentor competency in mentee satisfaction mediated by trust and moderated by perceptions based on the role (mentor vs. mentee) and the session content. The model explains 57% of the variability. Results support the relevance of trust in the mentoring relationship, and the influence of mentor competence in mentee satisfaction in university settings. Findings have implications for the conceptualization of mentoring models and provide relevant information to consider when designing training for new mentors in higher education. Findings can be used for theory building in mentoring relationships by providing contextual data linked to university settings in Southern Europe.2022-2

Eficacia de un programa de mentoría entre iguales en el abandono universitario y el rendimiento académico

Mentoring programs have been proposed to reduce dropout and increase academic performance. We analyzed the effect of peer mentoring on university dropout and academic performance in the context of Spain. We applied a quasi-experimental posttest-only control group design with 3,774 students (mentees, n = 1,887; control, n = 1,887). Mentees had participated in a peer mentoring program. We apply the student’s t-test, Cohen’s d, phi statistic, and chi-square statistic. Mentees exhibited lower dropout than controls and showed higher academic performance regardless of the area of knowledge. Results support the implementation of mentoring programs in Spanish universities with the goal of reducing student dropout and increasing academic performance. The research provides empirical evidence for theory building in higher education studies, developmental relationships, and integration programs.Se ha propuesto la aplicación de programas de mentoría para reducir la deserción universitaria y aumentar el rendimiento académico. En el artículo analizamos el efecto de la mentoría entre pares sobre el abandono universitario y el rendimiento académico en España. Aplicamos un diseño de grupo de control cuasiexperimental con medida post en una muestra de 3.774 estudiantes (mentorados, n = 1,887; control, n = 1,887). Los mentorados habían participado en un programa de mentoría entre pares. Aplicamos la prueba t de Student, la d de Cohen, el estadístico phi y el chi-cuadrado. Los mentorados presentaban un menor abandono que los controles y un mayor rendimiento académico independientemente del área de conocimiento. Los resultados avalan la implementación de programas de mentoría en las universidades españolas con el objetivo de reducir el abandono universitario y aumentar el rendimiento académico. La investigación proporciona evidencia empírica para la elaboración de teorías en estudios de educación superior, relaciones de desarrollo y programas de integración.Depto. de Psicología Social, del Trabajo y DiferencialFac. de PsicologíaTRUEpu

Economic Improvement of Artisanal Fishing by Studying the Survival of Discarded Plectorhinchus mediterraneus

Europe calls for the end to fisheries discards, which means bringing all caught fish (subject to minimum sizes or quotas) to land. This decision is beneficial to the ecosystem, since it forces the selectivity of the fishing gears to improve. However, artisanal fishermen find themselves in a vulnerable situation where their subsistence depends on catches with small profit margins. An exemption to this landing obligation exists, as it is also ruled that those animals whose survival is scientifically guaranteed may be returned to the sea. Here we study the survival of Plectorhinchus mediterraneus captured by hookline and gillnet, as well as their physiological recovery. Survival exceeds 93% in both cases. The physiological assessment of primary (cortisol) and secondary (energy mobilization, acid-base and hydromineral balance, and immune system) stress responses indicates that surviving animals are able to recover after fishing. Thus, we propose the optimal size of capture of this species to achieve greater economic benefit. For this, we rely on the prices according to size in recent years, as well as on the growth curves of the species. In this way, by releasing fish of less than 1 kg, the current benefits could be multiplied between 2.3 and 9.6 times. This pilot study lays the groundwork for regulating artisanal fisheries through scientific data related to survival of discards along with information on the sale prices

Uso de herramientas digitales educativas online para promover un aprendizaje activo de la Fisiología Animal (DIGIFISIO)

Depto. de Genética, Fisiología y MicrobiologíaFac. de Ciencias BiológicasFALSEsubmitte

Proceedings of the International Course Ceramic Materials in Building Heritage: conservation problems and intervention

Trabajos presentados en el International Course Ceramic Materials in Building Heritage (conservation problems and intervention), celebrado en Madrid el 29 y 30 de junio de 2016.Edited by Elena Mercedes Pérez Monserrat (IGEO), Natalia Pérez Ema (YOCOCU España) and Pilar Rubiales Fuentes (YOCOCU España).Ceramic material is certainly a key element in the cultural heritage, particularly in historical buildings, from antiquity to the present. Ceramics applied to architecture involves specific problems when addressing preservation, as well as conservation and restoration interventions. Knowledge about the origin and selection of suitable raw materials and better understanding of the technology used for the manufacture of ceramic parts involves important implications for the conservation of these materials. This course is coordinated and co-organized by YOUTH IN CONSERVATION OF CULTURAL HERITAGE Association YOCOCU-Spain, co-organized by Geosciences Institute IGEO (CSIC, UCM), Spanish Society of Ceramics and Glass.(SECV) and the Ceramic and Glass Institute (ICV), sponsored by ECERS, the Journal of European Ceramic Society Trust and SECV. The main goal of the course is to offer a training program of short duration focused on the ceramic material used in architectural heritage, including structural and decorative elements. Raw materials and technologies used for manufacturing, alteration and decay processes, characterization techniques for study and analysis, as well as new trends in conservation treatments will be addressed.Bruno Fabbri. Ceramic construction material in cultural heritage: typologies, manufacture and properties.-- Francisco Fernandes. Understanding the deterioration of old clay bricks.-- Mathilda Larsson Couthino. Biological colonization and biodeterioration of architectural ceramic materials.-- Mauro Francesco La Russa. Bricks and ceramics in underwater environment: Characterization and degradation.-- Manuel García Heras. Archaeometric characterization of historical ceramic materials: bricks, roofs and decorative tiles.-- Mónica Álvarez de Buergo. Non destructive techniques to measure surface properties.-- Miguel Gómez Heras. Non destructive techniques to measure bulk properties.-- Barbara Lubelli. Desalination of masonry by poulticing: laboratory research and application in the field.--Aitana Tamayo. Protective interventions and treatments in heritage buildings.-- Rob van Hees. Surface treatments for the conservation of historic masonry: blessing or risk?.-- Silvestro Ruffolo. Conservation of ceramics and bricks in underwater environment: state of art and new perspectives.-- Manuel Blanco. Preventive Conservation of Built Heritage.-- Elena Pérez Montserrat. Improving the knowledge of ceramic materials manufacture by means of analytical techniques.-- Carmen Pascual. Ceramic characterizacion of porcelain flooring tiles from La Casa del Labrador in Aranjuez (Madrid, Spain)Peer reviewe