The relationship of drug reimbursement with the price and the quality of pharmaceutical innovations

This paper studies the strategic interaction between pharmaceutical firms' pricing decisions and government agencies' reimbursement decisions which discriminate between patients by giving reimbursement rights to patients for whom the drug is most effective. We show that if the reimbursement decision preceeds the pricing decision, the agency only reimburses some patients if the private and public health benefits from the new drug diverge. That is, when (i) there are large externalities of consuming the drug and (ii) the difference in costs between the new drug and the alternative treatment is large. Alternatively, if the firm can commit to a price in advance of the reimbursement decision, we identify a strategic effect which implies that by committing to a high price ex ante, the firm can force a listing outcome and make the agency more willing to reimburse than in the absence of commitment

On the Potential of Leptonic Minimal Flavour Violation

Minimal Flavour Violation can be realized in several ways in the lepton sector due to the possibility of Majorana neutrino mass terms. We derive the scalar potential for the fields whose background values are the Yukawa couplings, for the simplest See-Saw model with just two right-handed neutrinos, and explore its minima. The Majorana character plays a distinctive role: the minimum of the potential allows for large mixing angles -in contrast to the simplest quark case- and predicts a maximal Majorana phase. This points in turn to a strong correlation between neutrino mass hierarchy and mixing pattern.Comment: 6 pages; version published on Physics Letters

On the Whitham hierarchy: dressing scheme, string equations and additional symmetrie

A new description of the universal Whitham hierarchy in terms of a factorization problem in the Lie group of canonical transformations is provided. This scheme allows us to give a natural description of dressing transformations, string equations and additional symmetries for the Whitham hierarchy. We show how to dress any given solution and prove that any solution of the hierarchy may be undressed, and therefore comes from a factorization of a canonical transformation. A particulary important function, related to the $\tau$-function, appears as a potential of the hierarchy. We introduce a class of string equations which extends and contains previous classes of string equations considered by Krichever and by Takasaki and Takebe. The scheme is also applied for an convenient derivation of additional symmetries. Moreover, new functional symmetries of the Zakharov extension of the Benney gas equations are given and the action of additional symmetries over the potential in terms of linear PDEs is characterized

On the Whitham hierarchy: dressing scheme, string equations and additional symmetrie

A new description of the universal Whitham hierarchy in terms of a factorization problem in the Lie group of canonical transformations is provided. This scheme allows us to give a natural description of dressing transformations, string equations and additional symmetries for the Whitham hierarchy. We show how to dress any given solution and prove that any solution of the hierarchy may be undressed, and therefore comes from a factorization of a canonical transformation. A particulary important function, related to the $\tau$-function, appears as a potential of the hierarchy. We introduce a class of string equations which extends and contains previous classes of string equations considered by Krichever and by Takasaki and Takebe. The scheme is also applied for an convenient derivation of additional symmetries. Moreover, new functional symmetries of the Zakharov extension of the Benney gas equations are given and the action of additional symmetries over the potential in terms of linear PDEs is characterized

Effects of galaxy interactions in different environments

We analyse star formation rates derived from photometric and spectroscopic data of galaxies in pairs in different environments using the 2dF Galaxy Redshift Survey (2dFGRS) and the Sloan Digital Sky Survey (SDSS). The two samples comprise several thousand pairs, suitable to explore into detail the dependence of star formation activity in pairs on orbital parameters and global environment. We use the projected galaxy density derived from the fifth nearest neighbour of each galaxy, with convenient luminosity thresholds to characterise environment in both surveys in a consistent way. Star formation activity is derived through the $\eta$ parameter in 2dFGRS and through the star formation rate normalised to the total mass in stars, $SFR/M^*$, given by Brinchmann et al. (2004) in the second data release SDSS-DR2. For both galaxy pair catalogs, the star formation birth rate parameter is a strong function of the global environment and orbital parameters. Our analysis on SDSS pairs confirms previous results found with the 2dFGRS where suitable thresholds for the star formation activity induced by interactions are estimated at a projected distance r_{\rm p} = 100 \kpc and a relative velocity $\Delta V = 350$ km $s^{-1}$. We observe that galaxy interactions are more effective at triggering important star formation activity in low and moderate density environments with respect to the control sample of galaxies without a close companion. Although close pairs have a larger fraction of actively star-forming galaxies, they also exhibit a greater fraction of red galaxies with respect to those systems without a close companion, an effect that may indicate that dust stirred up during encounters could be affecting colours and, partially, obscuring tidally-induced star formation.Comment: accepted MNRA

Quantum control of the motional states of trapped ions through fast switching of trapping potentials

We propose a new scheme for supplying voltages to the electrodes of microfabricated ion traps, enabling access to a regime in which changes to the trapping potential are made on timescales much shorter than the period of the secular oscillation frequencies of the trapped ions. This opens up possibilities for speeding up the transport of ions in segmented ion traps and also provides access to control of multiple ions in a string faster than the Coulomb interaction between them. We perform a theoretical study of ion transport using these methods in a surface-electrode trap, characterizing the precision required for a number of important control parameters. We also consider the possibilities and limitations for generating motional state squeezing using these techniques, which could be used as a basis for investigations of Gaussian-state entanglement.Comment: Accepted by New Journal of Physic