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The relationship of drug reimbursement with the price and the quality of pharmaceutical innovations
This paper studies the strategic interaction between pharmaceutical firms' pricing decisions and government agencies' reimbursement decisions which discriminate between patients by giving reimbursement rights to patients for whom the drug is most effective. We show that if the reimbursement decision preceeds the pricing decision, the agency only reimburses some patients if the private and public health benefits from the new drug diverge. That is, when (i) there are large externalities of consuming the drug and (ii) the difference in costs between the new drug and the alternative treatment is large. Alternatively, if the firm can commit to a price in advance of the reimbursement decision, we identify a strategic effect which implies that by committing to a high price ex ante, the firm can force a listing outcome and make the agency more willing to reimburse than in the absence of commitment
Quantum control of the motional states of trapped ions through fast switching of trapping potentials
We propose a new scheme for supplying voltages to the electrodes of
microfabricated ion traps, enabling access to a regime in which changes to the
trapping potential are made on timescales much shorter than the period of the
secular oscillation frequencies of the trapped ions. This opens up
possibilities for speeding up the transport of ions in segmented ion traps and
also provides access to control of multiple ions in a string faster than the
Coulomb interaction between them. We perform a theoretical study of ion
transport using these methods in a surface-electrode trap, characterizing the
precision required for a number of important control parameters. We also
consider the possibilities and limitations for generating motional state
squeezing using these techniques, which could be used as a basis for
investigations of Gaussian-state entanglement.Comment: Accepted by New Journal of Physic
Causality detection and turbulence in fusion plasmas
This work explores the potential of an information-theoretical causality
detection method for unraveling the relation between fluctuating variables in
complex nonlinear systems. The method is tested on some simple though nonlinear
models, and guidelines for the choice of analysis parameters are established.
Then, measurements from magnetically confined fusion plasmas are analyzed. The
selected data bear relevance to the all-important spontaneous confinement
transitions often observed in fusion plasmas, fundamental for the design of an
economically attractive fusion reactor. It is shown how the present method is
capable of clarifying the interaction between fluctuating quantities such as
the turbulence amplitude, turbulent flux, and Zonal Flow amplitude, and
uncovers several interactions that were missed by traditional methods.Comment: 26 pages, 14 figure
Survey for Emission-Line Galaxies: Universidad Complutense de Madrid List 3
A new low-dispersion objective-prism search for low-redshift (z<0.045)
emission-line galaxies (ELG) has been carried out by the Universidad
Complutense de Madrid with the Schmidt Telescope at the Calar-Alto Observatory.
This is a continuation of the UCM Survey, which was performed by visual
selection of candidates in photographic plates via the presence of the
Halpha+[NII]6584 blend in emission. In this new list we have applied an
automatic procedure, fully developed by us, for selecting and analyzing the ELG
candidates on the digitized images obtained with the MAMA machine. The analyzed
region of the sky covers 189 square degrees in nine fields near R.A.=14h & 17h,
Dec=25 deg. The final sample contains 113 candidates. Special effort has been
made to obtain a large amount of information directly from our uncalibrated
plates by using several external calibrations. The parameters obtained for the
ELG candidates allow for the study of the statistical properties for the
sample.Comment: 13 pages, 18 PostScript figures, 6 JPEG figures, Table 2 corrected.
Accepted for publication in Astrophysical Journal Supplements, also available
at http://www.ucm.es/info/Astrof/opera/LIST3_ApJS99
Abundances in Stars from the Red Giant Branch Tip to the Near the Main Sequence in M71: I. Sample Selection, Observing Strategy and Stellar Parameters
We present the sample for an abundance analysis of 25 members of M71 with
luminosities ranging from the red giant branch tip to the upper main sequence.
The spectra are of high dispersion and of high precision. We describe the
observing strategy and determine the stellar parameters for the sample stars
using both broad band colors and fits of H profiles. The derived
stellar parameters agree with those from the Yale stellar evolutionary
tracks to within 50 -- 100K for a fixed log g, which is within the level of the
uncertainties.Comment: Minor changes to conform to version accepted for publication, with
several new figures (Paper 1 of a pair
Sibling competition and not maternal allocation drives differential offspring feeding in a sexually size-dimorphic bird
Sex allocation models still fail to predict the complex sex ratio patterns in broods of vertebrates. A major problem when studying mother–brood interactions is the difficulty in disentangling hypotheses involving maternal preferences from processes that do not imply maternal manipulation. We studied maternal resource allocation in mixed-sex, same-sex and single-chick broods in the great bustard, Otis tarda. Females normally rear a single chick, and previous work has shown that maternal investment influences male more than female breeding success. Therefore, mothers of two-chick broods were assumed to be in good condition and candidates to show a preference for sons. Results showed that male chicks of mixed-sex broods remained close to the mother for twice as long as their sisters, and received double the number of maternal feedings. However, sex differences in maternal feeding rate disappeared when considering only simultaneous begging approaches from both siblings. Proximity to the mother and its interaction with begging approach intensity were the factors determining the higher begging success of male chicks. In single-chick broods, females did not receive fewer maternal feedings than males. Overall, our results suggest that female chicks of mixed-sex broods become outcompeted by their larger brothers, which remain close to the mother much longer, preventing their sisters from taking a larger share of maternal feedings. We conclude that mothers do not show a preference for feeding male over female chicks, and that the sex differences in feeding rate are determined by the higher food requirements of male chicks due to their sexually selected, much faster growth rates. The higher mortality of females in mixed-sex broods contrasts with the pattern of male-biased mortality typical in this species, and supports our interpretation of an asymmetric competitive ability of male offspring as the mechanism responsible for the sex bias in maternal expenditure.This work was supported by the Dirección General de Investigación Científica y Técnica (projects PB91-0081 and PB94-0068, with contributions from other projects awarded to J.C.A. for marking and radiotracking birds 1987–2013); the Instituto Nacional para la Conservación de la Naturaleza; and the Junta de Castilla y León. During the study, E.M. benefitted from a predoctoral fellowship of the Dirección General de Investigación Científica y Técnica. Research by J.C.A. and J.A.A. was supported by project CGL2012-36345 during the writing of the pape
Heat conduction in one dimensional systems: Fourier law, chaos, and heat control
In this paper we give a brief review of the relation between microscopic
dynamical properties and the Fourier law of heat conduction as well as the
connection between anomalous conduction and anomalous diffusion. We then
discuss the possibility to control the heat flow.Comment: 15 pages, 11 figures. To be published in the Proceedings of the NATO
Advanced Research Workshop on Nonlinear Dynamics and Fundamental
Interactions, Tashkent, Uzbekistan, Octo. 11-16, 200
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