Aplicación de un modelo de análisis fílmico para piezas del noticiario documental NO-DO: basado en el estudio formal y la ponderación sociocultural de las imágenes

Comunicaciones del IV Congreso Internacional sobre análisis fílmico celebrado en la Universitat Jaume I de Castellón 4,5 y 6 de mayo de 201

Riesgo cardiovascular en pacientes nonagenarios: Uso y consumo de recursos sanitarios

Las enfermedades cardiovasculares son una de las enfermedades más prevalentes entre la población de edad avanzada. A pesar de ello, no existen muchos estudios en personas mayores con discapacidades, ancianos frágiles o que vivan en residencias. Personas y métodos: entrevistamos a 82 pacientes mayores de 90 años ingresados en el HU Río Hortega, entre cuatro estudiantes para efectuar el TFG, cada uno analizamos un aspecto en concreto. Objetivos: analizar la frecuentación de consultas médica en atención primaria y especializada, urgencias e ingresos en el Hospital, y su relación con otros aspectos: lugar de residencia, deterioro mental, comorbilidad, calidad de vida relacionada con la salud y grado de dependencia para las actividades básicas e instrumentales de la vida diaria. Resultados: las mujeres y los pacientes que viven en el domicilio familiar acuden con mayor frecuencia a consultas médicas. Las personas con más comorbilidad acuden más a consultas y sufren más ingresos. Los pacientes con deterioro mental severo frecuentan menos las consultas pero ingresan más. Los pacientes dependientes para las actividades básicas de la vida diaria frecuentan más las consultas. Conclusiones: en pacientes de más de 90 años, la edad, el deterioro mental, la calidad de vida relacionada con la salud y la comorbilidad no condicionan más consultas, mayor uso de urgencias o más ingresos hospitalarios. Sin embargo una mayor dificultad de la movilidad y del cuidado personal de los pacientes se relaciona con más accesos a urgencias e ingresos hospitalarios.Grado en Medicin

Accelerating Sequence Alignment Using Processing-In-Memory

Recent advances in sequencing technologies have made sequencing analysis a fundamental tool for genomics and healthcare research. Before any biological insights can be drawn, sequence data has to be analyzed using complex and computational-intensive sequence analysis tools. In particular, sequence alignment is a fundamental building block present in numerous sequence analysis tools. However, DP-based sequence alignment implementations fail to scale with longer sequence lengths due to the quadratic memory requirements and quickly become memory-bounded. As a result, numerous research efforts have focused on developing efficient and scalable sequence alignment algorithms and hardware accelerators. Unfortunately, current state-of-the-art sequence alignment algorithms, namely the WFA and BiWFA algorithms, are still limited by memory constraints and struggle to scale efficiently on modern many-core architectures. Processing-In-Memory (PIM) is an emergent architectural paradigm that seeks to accelerate memory-bound applications by moving computation closer to the data to mitigate data-movement penalties. This work aims to develop a PIM-enabled implementation of the BiWFA algorithm optimized for the UPMEM architecture. Advances in genomics and sequencing technologies demand faster and more scalable analysis methods that can process longer sequences with higher accuracy. However, classical pairwise alignment methods, based on dynamic programming (DP), impose impractical computational requirements to align long and noisy sequences like those produced by PacBio, and Nanopore technologies. The recently proposed Wavefront Alignment (WFA) algorithm paves the way for more efficient alignment tools, improving time and memory complexity over previous methods. Notwithstanding the advantages of the WFA algorithm, modern high performance computing (HPC) platforms rely on accelerator-based architectures that exploit parallel computing resources to improve over classical computing CPUs. Hence, a GPU-enabled implementation of the WFA could exploit the hardware resources of modern GPUs and further accelerate sequence alignment in current genome analysis pipelines

¿Existen profármacos de sulfonamidas?

Las sulfamidas son uno de los grupos funcionales más importantes en el diseño de fármacos y están presentes en multitud de estructuras activas comercializadas (sulfasalazina, viagra, sulfamidas, antidiabéticos, diuréticos). Entre ellas, podemos encontrar alguno de los fármacos empleados en el tratamiento de la hipertensión pulmonar como el sildenafilo o el fasudil. Sin embargo, existen escasos ejemplos de profármacos del agrupamiento sulfonamida y hasta el momento no se ha descrito el empleo de sulfinamidas con esta finalidad. La ventaja potencial de este tipo de profármacos es su mayor hidrofilia, lo que podría mejorar las propiedades farmacocinéticas. Además, cabe esperar que su bioactivación a las correspondientes sulfonamidas en las condiciones oxidativas del pulmón sea sencilla. Es por eso que este trabajo se ha centrado en la posible existencia del agrupamiento sulfinamida como profármaco de sulfonamidas presentes en multitud de fármacos

Energetic metabolism in fasting sheep: regularization of metabolic profile by treatment with oral glucose, with prior handling of gastric groove

The objective of this research was to evaluate a possible corrective measure against negative metabolic states, as occurs in the advanced stage of gestation in ewes, and that sometimes produces a disease called pregnancy toxaemia. In the present research, we found that the joint administration of i.v. lysine-vasopressin (0.08 IU/kg body weight, BW) and an oral glucose solution (50 g) produces an increase in blood glucose, which persists for some time (up to 6 h); therefore, it could be used in the treatment of pregnancy toxaemia. This therapy is based on the fact that lysine-vasopressin induces gastric groove closure in adult ruminants, enabling orally administered glucose to reach the abomasum directly, from where it rapidly passes into the intestine and is immediately absorbed. We can say that the tested treatment causes a significant increase in blood glucose in ewes affected by toxaemia caused by fasting, which, although less marked than conventional therapy with intravenous drip glucose, remains longer, regularizing other parameters indicative of energy metabolism in fasting ewes

A new navigation paradigm for virtual reality: the guided visit through a virtual world

The three main navigation paradigms for virtual worlds, i.e., free navigation, automatic tours, and multiuser navigation show important limitations when dealing with guided visits that involve interactive cooperation among several users in 3D virtual worlds over the Internet. In this paper, we present our research into this issue and some important results. We propose a new navigation paradigm denominated guided visit through a virtual world, where the capacity of a user guiding several remote users through the virtual world is enriched with the capacity to dynamically interchange the role of guiding between the connected users. The user that acts as a guide moves freely through the virtual world, and his/her movements are reproduced by the browsers of the other guided users. We also present the architecture and the system we developed that implements this paradigm, as well as its integration in a working realworld application that demonstrates its use