Multi-wavelength Temporal Variability of the Blazar 3C 454.3 during 2014 Activity Phase

We present a multi-wavelength temporal analysis of the blazar 3C 454.3 during the high $\gamma$-ray active period from May-December, 2014. Except for X-rays, the period is well sampled at near-infrared (NIR)-optical by the \emph{SMARTS} facility and the source is detected continuously on daily timescale in the \emph{Fermi}-LAT $\gamma$-ray band. The source exhibits diverse levels of variability with many flaring/active states in the continuously sampled $\gamma$-ray light curve which are also reflected in the NIR-optical light curves and the sparsely sampled X-ray light curve by the \emph{Swift}-XRT. Multi-band correlation analysis of this continuous segment during different activity periods shows a change of state from no lags between IR and $\gamma$-ray, optical and $\gamma$-ray, and IR and optical to a state where $\gamma$-ray lags the IR/optical by $\sim$3 days. The results are consistent with the previous studies of the same during various $\gamma$-ray flaring and active episodes of the source. This consistency, in turn, suggests an extended localized emission region with almost similar conditions during various $\gamma$-ray activity states. On the other hand, the delay of $\gamma$-ray with respect to IR/optical and a trend similar to IR/optical in X-rays along with strong broadband correlations favor magnetic field related origin with X-ray and $\gamma$-ray being inverse Comptonized of IR/optical photons and external radiation field, respectively.Comment: 15 pages, 5 figures, 1 table, MNRAS accepte

Noncommutative N=2 Strings

We analyze open and mixed sector tree-level amplitudes of N=2 strings in a space-time with (2,2) signature, in the presence of constant B field. The expected topological nature of string amplitudes in the open sector is shown to impose nontrivial constraints on the corresponding noncommutative field theory. In the mixed sector, we first compute a 3-point function and show that the corresponding field theory is written in terms of a generalized *-product. We also analyze a 4-point function (A_{oooc}) of the mixed sector in Theta ---> infinity limit.Comment: 1+9 pages, LaTex, 1 ps figure; final version to appear in JHE

Differentially localized survivin and STAT3 as markers of gastric cancer progression: Association with Helicobacter pylori

BackgroundLocalization and differential expression of STAT3 and survivin in cancer cells are often related to distinct cellular functions. The involvement of survivin and STAT3 in gastric cancer has been reported in separate studies but without clear understanding of their kinetics in cancer progression.MethodsWe examined intracellular distribution of STAT3 and survivin in gastric adenocarcinoma and compared it with normal and precancer tissues using immunoblotting and immunohistochemistry.ResultsAnalysis of a total of 156 gastric samples comprising 61 histologically normal, 30 precancerous tissues (comprising intestinal metaplasia and dysplasia), and 65 adenocarcinomas, collected as endoscopic biopsies from treatment naïve study participants, revealed a significant (P < .001) increase in overall protein levels. Survivin expression was detectable in both cytoplasmic (90.8%) and nuclear (87.7%) compartments in gastric adenocarcinomas lesions. Precancerous dysplastic gastric lesions exhibited a moderate survivin expression (56.7%) localized in cytoplasmic compartment. Similarly, STAT3 and pSTAT3 expression was detected at high level in gastric cancer lesions. The levels of compartmentalized expression of survivin and STAT3/pSTAT3 correlated in precancerous and adenocarcinoma lesions. Although overexpression of these proteins was found associated with the tobacco use and alcohol consumption, their expression invariably and strongly correlated with concurrent Helicobacter pylori infection. Receiver operating characteristic analysis of nuclear survivin, STAT3, and pSTAT3 in different study groups showed acceptable positive and negative predictive values with area under the curve above 0.8 (P < .001).ConclusionOverall, our results suggest that overall increase in survivin and STAT3 and their subcellular localization are key determinants of gastric cancer progression, which can be collectively used as potential disease biomarkers and therapeutic targets for gastric cancer.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/144680/1/cnr21004-Supplementary_Methods_20180313.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/144680/2/cnr21004-sup-0001-F1.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/144680/3/cnr21004_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/144680/4/cnr21004.pd