Exploring the Links Between Gut Bacteria-Related Metabolites, Coronary Artery Disease (CAD) Risk, and Heart Failure (HF).

This short review synthesizes recent advances in microbiome research on CVD and the associated cardiometabolic phenotypes, moving our understanding from outcomes to causality special emphasis is placed on microbiome and compound/metabiotic pathways, focusing on short-chain fatty acids, trimethylamine N-oxide, and phenylacetylglutamine. Modifying the gut microbiota through specific dietary interventions provides a potential way to identify novel therapeutic targets and refine dietary recommendations for prevention

Exploring the Potential Links Between Gut Bacteria-Related Metabolites and the Risk of Cardiovascular Diseases

This mini-review examines the complex relationship between the gut microbiota and human health, with a special focus on its role in conditions such as inflammatory bowel disease (IBD) and cardiovascular disease (CVD). It explores how dietary patterns can affect the composition of the gut microbiota, thus contributing to the development of various diseases. The gut microbiota is crucial in the production of metabolites such as trimethylamine N-oxide (TMAO), which play a significant role in the development of both IBD and CVD. High levels of TMAO and other metabolites, such as phenylacetylglutamine, have been linked to an increased risk of CVD. The review highlights the potential of dietary interventions and therapies designed to modulate the gut microbiota in reducing these risks. Following a Mediterranean diet may offer cardiovascular protection, emphasizing the need for further research into the molecular mechanisms of diet-related changes in the microbiota.This is a preprint from Alobaidi, Larsa, Jessica L. Ward, Karin Allenspach, and Jonathan P. Mochel. "Exploring the Potential Links Between Gut Bacteria-Related Metabolites and the Risk of Cardiovascular Diseases." (2023). doi: https://doi.org/10.20944/preprints202311.0440.v1. Copyright by the authors 2023. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited