Depression and Psychotherapy: The Importance of a Psychotherapeutic Approach Focused on Logical Reasoning and Functioning

Many patients who show up with depressive and anxious symptomology have, or have had, interpersonal conflicts that triggered or contributed to the aggravation of the symptomology herein explained. Clinical experience has taught us that many people have difficulty in maintaining Faultless Logical Reasoning (FLR) and, even if FLR is present, they have difficulty in maintaining Faultless Logical Functioning (FLF). In clinical practice, psychotherapists saw people that in consequence of their difficulty in FLR/FLF involves in conflicts that brought them interpersonal problems in relationships, in business, work, and in other areas of their life. Consequently, these problems will be followed by anxious and depressive symptomatology. Almost always, this symptomology is accompanied by intense emotional changes. With this clinical case of a patient with depression, and its treatment, is demonstrated the importance to investigate the capacity of patients to function and think, respectively, with FLF and FLR. This work has proved very exciting because Logic-Based Psychotherapy (LBP) provide pedagogy to think better, to improve emotional processing, introspection, and more profound and rigorous analysis and responses. If the responses of the subject are more logical, it will result in fewer conflicts, less ill will, and fewer disagreements, which will lead to fewer cases of depression

Gloeothece sp.—exploiting a new source of antioxidant, anti-inflammatory, and antitumor agents

Bioactive lipidic compounds of microalgae, such as polyunsaturated fatty acids (PUFA) and carotenoids, can avoid or treat oxidation-associated conditions and diseases like inflammation or cancer. This study aimed to assess the bioactive potential of lipidic extracts obtained from Gloeothece sp.–using Generally Recognized as Safe (GRAS) solvents like ethanol, acetone, hexane:isopropanol (3:2) (HI) and ethyl lactate. The bioactive potential of extracts was assessed in terms of antioxidant (ABTS•+, DPPH•,• NO and O2• assays), anti-inflammatory (HRBC membrane stabilization and Cox-2 screening assay), and antitumor capacity (death by TUNEL, and anti-proliferative by BrdU incorporation assay in AGS cancer cells); while its composition was characterized in terms of carotenoids and fatty acids, by HPLC-DAD and GC-FID methods, respectively. Results revealed a chemopreventive potential of the HI extract owing to its ability to: (I) scavenge- NO• radical (IC50, 1258 ± 0.353 µg·mL-1 ); (II) inhibit 50% of COX-2 expression at 130.2 ± 7.4 µg·mL-1; (III) protect 61.6 ± 9.2% of lysosomes from heat damage, and (IV) induce AGS cell death by 4.2-fold and avoid its proliferation up to 40% in a concentration of 23.2 ± 1.9 µg·mL-1 . Hence, Gloeothece sp. extracts, namely HI, were revealed to have the potential to be used for nutraceutical purposes.This research was supported by national funds through FCT—Foundation for Science and Technology within the scope of UIDB/04423/2020, granted to CIIMAR and UIDB/00511/2020 granted to LEPABE funded by national funds through FCT/MCTES (PIDDAC)

Communication in Clinical Practice, the Perspective of Patients with Cancer: Translation of the PACE (Patient Assessment of Cancer Communication Experiences) Questionnaire to European Portuguese

Introduction: Communication in clinical practice is essential to healthcare quality, especially in Oncology. The Patient Assessment of Communication Experiences questionnaire evaluates the perspective of cancer patients towards communication and identifies areas that can be improved. This study consists in its translation and validation to European Portuguese, to identify these areas. Material and methods: We performed a descriptive, observational, cross-sectional study. The translation was conducted according to the World Health Organization's guidelines. We applied the questionnaires to a convenience sample, in patients under systemic antineoplastic treatment at the Day Hospital of Centro Hospitalar Universitário do Porto, between January and March 2020. We calculated the Cronbach's Alpha for each phase of care, the bivariate and multiple correlations and, for each question, the percentage of "non applicable" and most positive answers. Results: We had 100 participants. The instrument we obtained ha good internal consistency, but the classification of some questions does not correlate sufficiently with the global opinion about the experiences with communication in the respective phase. The diagnosis phase revealed a lower proportion of positive experiences, particularly in terms of receiving the bad news. Conclusion: This study translates and validates part of the communication assessment instrument PACE to the Portuguese language and elicits the necessity to invest in the phase of diagnosis and disclosure of bad news.ste trabalho não recebeu qualquer tipo de suporte financeiro de nenhuma entidade no domínio público ou privado

Compact Trip Representation over Networks

The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-319-46049-9_23[Abstract] We present a new Compact Trip Representation ( CTRCTR ) that allows us to manage users’ trips (moving objects) over networks. These could be public transportation networks (buses, subway, trains, and so on) where nodes are stations or stops, or road networks where nodes are intersections. CTRCTR represents the sequences of nodes and time instants in users’ trips. The spatial component is handled with a data structure based on the well-known Compressed Suffix Array ( CSACSA ), which provides both a compact representation and interesting indexing capabilities. We also represent the temporal component of the trips, that is, the time instants when users visit nodes in their trips. We create a sequence with these time instants, which are then self-indexed with a balanced Wavelet Matrix ( WMWM ). This gives us the ability to solve range-interval queries efficiently. We show how CTRCTR can solve relevant spatial and spatio-temporal queries over large sets of trajectories. Finally, we also provide experimental results to show the space requirements and query efficiency of CTRCTR .Ministerio de Economía y Competitividad; TIN2013-46238-C4-3-RMinisterio de Economía y Competitividad; TIN2013-47090-C3-3-PMinisterio de Economía y Competitividad; IDI-20141259Ministerio de Economía y Competitividad; ITC-20151305Ministerio de Economía y Competitividad; ITC-20151247Xunta de Galicia; GRC2013/053Chile.Fondo Nacional de Desarrollo Científico y Tecnológico; 1140428Chile. Instituto de Sistemas Complejos de Ingeniería ; FBO 1

Anesthesia of Epinephelus marginatus with essential oil of Aloysia polystachya: an approach on blood parameters

This study investigated the anesthetic potential of the essential oil (EO) of Aloysia polystachya in juveniles of dusky grouper (Epinephelus marginatus). Fish were exposed to different concentrations of EO of A. polystachya to evaluate time of induction and recovery from anesthesia. In the second experiment, fish were divided into four groups: control, ethanol and 50 or 300 mu L L-1 EO of A. polystachya, and each group was submitted to induction for 3.5 min and recovery for 5 or 10 min. The blood gases and glucose levels showed alterations as a function of the recovery times, but Na+ and K+ levels did not show any alteration. In conclusion, the EO from leaves of A. polystachya is an effective anesthetic for dusky grouper, because anesthesia was reached within the recommended time at EO concentrations of 300 and 400 mu L L-1. However, most evaluated blood parameters showed compensatory responses due to EO exposure.Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul/Programa de Apoio a Nucleos de Excelencia (FAPERGS/PRONEX) [10/0016-8]; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [470964/2009-0]; Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior, Brazil (CAPES)info:eu-repo/semantics/publishedVersio

Effects of temperature on thick branes and the fermion (quasi-)localization

Following Campos's work [Phys. Rev. Lett. 88, 141602 (2002)], we investigate the effects of temperature on flat, de Sitter (dS), and anti-de Following Campos's work [Phys. Rev. Lett. \textbf{88}, 141602 (2002)], we investigate the effects of temperature on flat, de Sitter (dS), and anti-de Sitter (AdS) thick branes in five-dimensional (5D) warped spacetime, and on the fermion (quasi-)localization. First, in the case of flat brane, when the critical temperature reaches, the solution of the background scalar field and the warp factor is not unique. So the thickness of the flat thick brane is uncertain at the critical value of the temperature parameter, which is found to be lower than the one in flat 5D spacetime. The mass spectra of the fermion Kaluza-Klein (KK) modes are continuous, and there is a series of fermion resonances. The number and lifetime of the resonances are finite and increase with the temperature parameter, but the mass of the resonances decreases with the temperature parameter. Second, in the case of dS brane, we do not find such a critical value of the temperature parameter. The mass spectra of the fermion KK modes are also continuous, and there is a series of fermion resonances. The effects of temperature on resonance number, lifetime, and mass are the same with the case of flat brane. Last, in the case of AdS brane, {the critical value of the temperature parameter can less or greater than the one in the flat 5D spacetime.} The spectra of fermion KK modes are discrete, and the mass of fermion KK modes does not decrease monotonically with increasing temperature parameter.Comment: 24 pages, 15 figures, published versio

Mutant Huntingtin induces activation of the Bcl-2/adenovirus E1B 19-kDa interacting protein (BNip3)

Huntington's disease (HD) is a neurodegenerative disorder characterized by progressive neuronal death in the basal ganglia and cortex. Although increasing evidence supports a pivotal role of mitochondrial dysfunction in the death of patients' neurons, the molecular bases for mitochondrial impairment have not been elucidated. We provide the first evidence of an abnormal activation of the Bcl-2/adenovirus E1B 19-kDa interacting protein 3 (BNip3) in cells expressing mutant Huntingtin. In this study, we show an abnormal accumulation and dimerization of BNip3 in the mitochondria extracted from human HD muscle cells, HD model cell cultures and brain tissues from HD model mice. Importantly, we have shown that blocking BNip3 expression and dimerization restores normal mitochondrial potential in human HD muscle cells. Our data shed light on the molecular mechanisms underlying mitochondrial dysfunction in HD and point to BNip3 as a new potential target for neuroprotective therapy in HD

Análise antropométrica e dietética de surfistas amadores

O Surf é um esporte popular no Brasil, porém dados referentes à antropometria e dietéticos nos surfistas brasileiros ainda são limitados. Sendo assim, o objetivo da presente pesquisa foi verificar as características antropométricas e nutricionais de surfistas amadores brasileiros. Para tanto foram analisados seis surfistas do sexo masculino com idade média de 27,6 ± 2,7 anos, massa corporal de 75 ± 7,8 kg e estatura de 179,3 ± 5,4 cm. O percentual de gordura foi determinado por meio da bioimpedância elétrica e os valores encontrados foram de 15,6 ± 3,6 %. Para averiguar o consumo alimentar dos atletas foi utilizado o questionário Semi-quantitativo de frequência alimentar. Em relação ao grupo óleos 39,1%, cereais e leguminosas 41,5%, produtos diet e light 70,6% raramente ou nunca os mesmos eram consumidos p˂0,05. Em conclusão, os sufistas do presente estudo, se apresentaram mais altos, pesados e com %G superior aos registrados pela literatura, e mostraram uma inadequação alimentar, não coerente e balanceada que contemplem as necessidades diárias de nutrientes, para sua prática esportiva. ABSTRACT Anthropometric and dietetic analysis in amateur surfersSurfing is a popular sport in Brazil, however, data on anthropometry and dietetics in Brazilian surfers are still limited. Therefore, the objective of the present research was to verify the anthropometric and nutritional characteristics of Brazilian amateur surfers. For that, six surfers were analyzed with the mean age of 27.6 ± 2.7, body mass of 75 ± 7.8 kg and 179.3 ± 5.4 cm height. The percentage of fat was determined by electrical bioimpedance and the found values were 15.6 ± 3.6 %. The semi-quantitative food frequency questionnaire was used to determine the food intake of the athletes. In relation to the group oils 39.1%, cereals and legumes 41.5%, diet and light products 70.6% rarely or never they were consumed p˂0.05. In conclusion, the surfers of this study, they showed higher, heavier and G% higher than recorded in the literature, and showed an inadequate diet, not consistent and balanced that address the daily nutrient requirements for your sport

T Cell-Dependence of Lassa Fever Pathogenesis

Lassa virus (LASV), the causative agent of Lassa fever (LF), is endemic in West Africa, accounting for substantial morbidity and mortality. In spite of ongoing research efforts, LF pathogenesis and mechanisms of LASV immune control remain poorly understood. While normal laboratory mice are resistant to LASV, we report that mice expressing humanized instead of murine MHC class I (MHC-I) failed to control LASV infection and develop severe LF. Infection of MHC-I knockout mice confirmed a key role for MHC-I-restricted T cell responses in controlling LASV. Intriguingly we found that T cell depletion in LASV-infected HHD mice prevented disease, irrespective of high-level viremia. Widespread activation of monocyte/macrophage lineage cells, manifest through inducible NO synthase expression, and elevated IL-12p40 serum levels indicated a systemic inflammatory condition. The absence of extensive monocyte/macrophage activation in T cell-depleted mice suggested that T cell responses contribute to deleterious innate inflammatory reactions and LF pathogenesis. Our observations in mice indicate a dual role for T cells, not only protecting from LASV, but also enhancing LF pathogenesis. The possibility of T cell-driven enhancement and immunopathogenesis should be given consideration in future LF vaccine development