1 research outputs found
Lisinopril has a cardio-protective effect on experimental acute autoimmune myocarditis in rats
The present study investigated the effect of
lisinopril on experimental autoimmune myocarditis
(EAM) in rats, a histologically similar model to human
acute myocarditis.
Animals and methods. Twenty four, six week-old
male Wistar rats were randomly allocated into 4 groups
of 6 rats each. Group I received no treatment. Group II
received lisinopril at a dose of 15 mg/kg/day suspended
in 1 ml of 2% gum acacia daily, from day 1 to day 21. To
induce myocarditis, animals of groups III and IV were
injected by 1 mg of porcine cardiac myosin on days 1
and 8. In addition, animals of group IV received
lisinopril in gum acacia daily, from day 1 to day 21. All
rats were sacrificed on day 21. Serum levels of creatine
phosphokinase, troponin-T, tumor necrosis factor-α and
interleukin-6 were estimated. Hearts were processed for
histopathological, as well as immunohistochemical study
for thioredoxin (TRX) immunoreactivity.
Results. The wall of hearts from rats of myocarditislisinopril group showed mild focal myocarditis and a
significant decrease of the mean percentage of pyknotic
nuclei in cardiomyocytes, coincident with a significant
decrease in serum biomarkers levels and TRX
immunoreactivity, compared to myocarditis group.
Conclusion. The present study suggested a cardioprotective effect of lisinopril on acute EAM in rats,
probably through a mechanism related to its suppressive
effect on angiotensin II formation