The investigation of smart magnetic nanoparticles for use in the hyperthermia treatment of cancer

Self-controlled temperature nanoparticles as a form of hyperthermia treatment to fight against cancer

A comparison of methods for the determination of the magnetocrystalline anisotrophy constant in an Fe3O4-based ferrofluid

Biomedical applications of nano-sized magnetic materials

Magneto-optic Effects in Ferrofluids

Ferrofluids are stable colloidal suspensions of superparamagnetic nanoparticles in a carrier liquid. The ordering and phase transitions of these polarizable media under the effect of an externally applied dc magnetic field are accompanied by a number of magneto-optic effects. Light scattering, in particular, has been used in studies investigating the kinematics of the field-induced self-assembly of nanoparticles in chain-like structures. In previous reports we discussed the correlation between the time-dependent light-scattering patterns and the creation of such field-induced ordered structures of nanoparticles in the ferrofluid. This present work is the first reported systematic study of the morphing of the light scattering patterns with the thickness of the ferrofluid layer (0.1 mm to 10 mm) and with temperature, in ferrofluids consisting of water suspensions of dextran-coated iron oxide nanoparticles. In particular we discuss the origin and angular dependence of an elliptical pattern produced by light scattered through thin layers (\u3c;1 mm) of ferrofluids and contrast it with the patterns produced by longer light paths (10 mm) through the ferrofluid

Near-room-temperature magnetocaloric properties of La1−xSrxMnO3 (x = 0.11, 0.17, and 0.19) nanoparticles

The growth of chemically stable magnetic materials showing a magnetic transition near room temperature with a strong magnetocaloric effect is important for the development of roomtemperature magnetic refrigeration technology. Single-phase nanoparticles of La1−xSrxMnO3 (x = 0.11, 0.17, and 0.19) (LSMO) materials in the rhombohedral crystal structure with particle sizes between 20 nm and 30 nm were prepared using the sol-gel method. The crystal structure, morphology, magnetic properties and magnetocaloric effect (MCE)were investigated. The ferromagnetic to paramagnetic phase transitions of these nanoparticles are of second order in nature and the transition temperatures(Tc)lie between 284 K and 327 K. The magnetic entropy change (ΔSM) and relative cooling power(RCP) exhibit a linear dependence on the applied magnetic field. All samples show relatively large cooling efficiency with ΔSM,max of 3.26 Jkg−1 K−1 for La0.89Sr0.11MnO3 at 297 K and RCP of 201 Jkg−1 for La0.81Sr0.19MnO3 both measured at H = 30 kOe. These results suggest that the LSMO nanoparticles have potential for room-temperature magnetic refrigeration

1327. The Diagnosis of Subarachnoid Neurocysticercosis Is Often Delayed And Other Findings of a Multicenter Retrospective in the USA

Abstract Background Subarachnoid (racemose) neurocysticercosis (SANCC) is an uncommon but severe form of Taenia solium infection. There is limited evidence to guide clinical management of these patients. Methods We performed a multicenter retrospective chart review of 15 U.S. sites. A total of 69 subjects with racemose disease were entered. Results The most common region of exposure was Mexico (67%) followed by Central America (24%). Median age was 43 years (range 15-76) and 71% were male. Common symptoms at the time of index admission were headache (80%), nausea/vomiting (46%), dizziness (44%), and blurry vision (33%). Cysts were intracranial in 64 (93%) subjects and exclusively intraspinal in 4. One patient had meningitis without visible cystic lesions. Incident admission magnetic resonance imaging (MRI) demonstrated ventriculomegaly in 41 (59%) and focal findings in 9 (13%) including ischemic infarct, subarachnoid hemorrhage, and/or arterial aneurysm. For 55 (80%), SANCC was first diagnosed during the index admission. Of these, 23 (42%) had prior medical visits and substantial delay in diagnosis (i.e. previously seen with hydrocephalus [27%], stroke [5.5%], and/or meningitis [11%], missed diagnostic radiologic features [4%], or inadequate imaging [5.5%]). Of the 69 subjects, 54% underwent a neurosurgical procedure during index admission (cyst removal n=16, EVD/shunt/ventriculostomy n=24). At the time of discharge, 6 (8.6%) patients were not given albendazole and/or praziquantel due to cost or availability. Six months following discharge, 4 weeks was associated with increased risk for new cyst development on follow up imaging at a median of 3.8 years following discharge (range 2.6 months-8 years). Those with a delayed diagnosis received a significantly longer duration of corticosteroids (median 8 weeks) than those without a delay (median 5 weeks, p=0.047). Conclusion The diagnosis of SANCC is often missed, and most patients require neurosurgical intervention. Antiparasitic therapy is suboptimal, especially with regimens developed for parenchymal NCC. Disclosures Jeffrey D. Jenks, MD, MPH, Astellas: Grant/Research Support|F2G: Grant/Research Support|Pfizer: Grant/Research Suppor