The Weight of Time: Time influences on overweight and obesity in women

We know that adults’ weight increases with age, at least until around the age of 55 years or older. Recent National Australian surveys show that men and women of all age groups were heavier in 2000 than in 1995 or 1990. These studies also found that a greater proportion of people of all ages were overweight or obese in 2000 than in the previous surveys. These studies also suggested that different generations, also known as ‘birth cohorts’, had different patterns of weight gain. These birth cohort influences mean that the year a person is born and the unique set of experiences people born at that time experience, have an effect on weight gain patterns. People born at other times experience different conditions and have different weight gain patterns. Some birth cohorts or ‘generations’ are well-known, such as the ‘baby boomer’ generation, or pre-war generation. For example, Australians born in the first three decades of the twentieth century experienced World War I and II and the Great Depression during their childhood and early adult life. During these times food was scarce and everyday life required high levels of physical activity. This group overall had lower body weights than more recent generations, meaning they were less at risk of becoming obese. Australians born after 1980 were born into an advanced technological society with greater availability of food, a vastly increased range of food products and increasing serving sizes. At the same time, levels of physical activity in everyday life have been decreasing. Together these factors produce an obesogenic environment. The three National Health surveys, conducted by the Australian Bureau of Statistics for the Australian Institute of Health and Welfare in 1990, 1995 and 2000, produced data which the NSW Centre for Overweight and Obesity has analyzed to find out what effects three time factors -- ageing, the time of the surveys and birth cohort, have on body mass index (BMI) and the prevalence of overweight and obesity. [Note – BMI used as the indicator of weight status, where BMI = weight (kg)/height2 (M2)] This report provides an overview of key findings of the analyses of the effects of these three time factors on female weight patterns. The complete findings have been published in a comprehensive technical report. The results from the analysis of the effect of birth cohorts have been used to predict the mean body mass index of women in NSW in 2010. The graphs in this report show the results for women, and the results for men are available in a separate document. The overall patterns and implications for men are generally similar to those for women. NS

The Weight of Time: Time influences on overweight and obesity in men

We know that adults’ weight increases with age, at least until around the age of 55 years or older. Recent National Australian surveys show that men and women of all age groups were heavier in 2000 than in 1995 or 1990. These studies also found that a greater proportion of people of all ages were overweight or obese in 2000 than in the previous surveys. These studies also suggested that different generations, also known as ‘birth cohorts’, had different patterns of weight gain. These birth cohort influences mean that the year a person is born and the unique set of experiences people born at that time experience, have an effect on weight gain patterns. People born at other times experience different conditions and have different weight gain patterns. Some birth cohorts or ‘generations’ are well-known, such as the ‘baby boomer’ generation, or pre-war generation. For example, Australians born in the first three decades of the twentieth century experienced World War I and II and the Great Depression during their childhood and early adult life. During these times food was scarce and everyday life required high levels of physical activity. This group overall had lower body weights than more recent generations, meaning they were less at risk of becoming obese. Australians born after 1980 were born into an advanced technological society with greater availability of food, a vastly increased range of food products and increasing serving sizes. At the same time, levels of physical activity in everyday life have been decreasing. Together these factors produce an obesogenic environment. The three National Health surveys, conducted by the Australian Bureau of Statistics for the Australian Institute of Health and Welfare in 1990, 1995 and 2000, produced data which the NSW Centre for Overweight and Obesity has analyzed to find out what effects three time factors -- ageing, the time of the surveys and birth cohort -- have on body mass index (BMI) and the prevalence of overweight and obesity. [Note – BMI used as the indicator of weight status, where BMI = weight (kg)/height2 (M2)] This report provides an overview of key findings of the analyses of the effects of these three time factors on male weight patterns. The complete findings have been published in a comprehensive technical report. The results from the analysis of the effect of birth cohorts have been used to predict the mean body mass index of men in NSW in 2010. The graphs in this report show the results for men but the results for women are available. The overall patterns and implications for women are generally similar to those for men

Scintigraphic features of Morquio's syndrome: a case report

<p>Abstract</p> <p>Introduction</p> <p>To the best of our knowledge, we present for the first time the bone scintigraphy findings of a patient with Morquio's syndrome.</p> <p>Case presentation</p> <p>A 46-year-old Caucasian man with Morquio's syndrome presented with lower back pain six weeks after a left total hip replacement. A whole body bone scan demonstrated an anthropomorphic skeletal pattern consistent with a mucopolysaccharide storage disease, thereby showing the cause of the patient's pain.</p> <p>Conclusions</p> <p>To the best of our knowledge, the bone scintigraphy findings of a case of Morquio's syndrome have never before been published. We present our case report to add to the knowledge we have of this rare disease.</p

Interrelations Between the Neutron's Magnetic Interactions and the Magnetic Aharonov-Bohm Effect

It is proved that the phase shift of a polarized neutron interacting with a spatially uniform time-dependent magnetic field, demonstrates the same physical principles as the magnetic Aharonov-Bohm effect. The crucial role of inert objects is explained, thereby proving the quantum mechanical nature of the effect. It is also proved that the nonsimply connectedness of the field-free region is not a profound property of the system and that it cannot be regarded as a sufficient condition for a nonzero phase shift.Comment: 18 pages, 1 postscript figure, Late

Relationship between physiological measures of excitability and levels of glutamate and GABA in the human motor cortex

Magnetic resonance spectroscopy (MRS) allows measurement of neurotransmitter concentrations within a region of interest in the brain. Inter-individual variation in MRS-measured GABA levels have been related to variation in task performance in a number of regions. However, it is not clear how MRS-assessed measures of GABA relate to cortical excitability or GABAergic synaptic activity. We therefore performed two studies investigating the relationship between neurotransmitter levels as assessed by MRS and transcranial magnetic stimulation (TMS) measures of cortical excitability and GABA synaptic activity in the primary motor cortex. We present uncorrected correlations, where the P value should therefore be considered with caution. We demonstrated a correlation between cortical excitability, as assessed by the slope of the TMS input-output curve and MRS-assessed glutamate levels (r = 0.803, P = 0.015) but no clear relationship between MRS-assessed GABA levels and TMS-assessed synaptic GABA(A) activity (2.5 ms inter-stimulus interval (ISI) short-interval intracortical inhibition (SICI); Experiment 1: r = 0.33, P = 0.31; Experiment 2: r = -0.23, P = 0.46) or GABA(B) activity (long-interval intracortical inhibition (LICI); Experiment 1: r = -0.47, P = 0.51; Experiment 2: r = 0.23, P = 0.47). We demonstrated a significant correlation between MRS-assessed GABA levels and an inhibitory TMS protocol (1 ms ISI SICI) with distinct physiological underpinnings from the 2.5 ms ISI SICI (r = -0.79, P = 0.018). Interpretation of this finding is challenging as the mechanisms of 1 ms ISI SICI are not well understood, but we speculate that our results support the possibility that 1 ms ISI SICI reflects a distinct GABAergic inhibitory process, possibly that of extrasynaptic GABA tone

Parametric coupling between macroscopic quantum resonators

Time-dependent linear coupling between macroscopic quantum resonator modes generates both a parametric amplification also known as a {}"squeezing operation" and a beam splitter operation, analogous to quantum optical systems. These operations, when applied properly, can robustly generate entanglement and squeezing for the quantum resonator modes. Here, we present such coupling schemes between a nanomechanical resonator and a superconducting electrical resonator using applied microwave voltages as well as between two superconducting lumped-element electrical resonators using a r.f. SQUID-mediated tunable coupler. By calculating the logarithmic negativity of the partially transposed density matrix, we quantitatively study the entanglement generated at finite temperatures. We also show that characterization of the nanomechanical resonator state after the quantum operations can be achieved by detecting the electrical resonator only. Thus, one of the electrical resonator modes can act as a probe to measure the entanglement of the coupled systems and the degree of squeezing for the other resonator mode.Comment: 15 pages, 4 figures, submitte

Double deletion of Panx1 and Panx3 affects skin and bone but not hearing

Pannexins (Panxs), large-pore channel forming glycoproteins, are expressed in a wide variety of tissues including the skin, bone, and cochlea. To date, the use of single knock-out mouse models of both Panx1 and Panx3 have demonstrated their roles in skin development, bone formation, and auditory phenotypes. Due to sequence homology between Panx1 and Panx3, when one Panx is ablated from germline, the other may be upregulated in a compensatory mechanism to maintain tissue homeostasis and function. To evaluate the roles of Panx1 and Panx3 in the skin, bone, and cochlea, we created the first Panx1/Panx3 double knock-out mouse model (dKO). These mice had smaller litters and reduced body weight compared to wildtype controls. The dKO dorsal skin had decreased epidermal and dermal area as well as decreased hypodermal area in neonatal but not in older mice. In addition, mouse skull shape and size were altered, and long bone length was decreased in neonatal dKO mice. Finally, auditory tests revealed that dKO mice did not exhibit hearing loss and were even slightly protected against noise-induced hearing damage at mid-frequency regions. Taken together, our findings suggest that Panx1 and Panx3 are important at early stages of development in the skin and bone but may be redundant in the auditory system. Key messages Panx double KO mice had smaller litters and reduced body weight. dKO skin had decreased epidermal and dermal area in neonatal mice. Skull shape and size changed plus long bone length decreased in neonatal dKO mice. dKO had no hearing loss and were slightly protected against noise-induced damage

Circuit QED scheme for realization of the Lipkin-Meshkov-Glick model

We propose a scheme in which the Lipkin-Meshkov-Glick model is realized within a circuit QED system. An array of N superconducting qubits interacts with a driven cavity mode. In the dispersive regime, the cavity mode is adiabatically eliminated generating an effective model for the qubits alone. The characteristic long-range order of the Lipkin-Meshkov-Glick model is here mediated by the cavity field. For a closed qubit system, the inherent second order phase transition of the qubits is reflected in the intensity of the output cavity field. In the broken symmetry phase, the many-body ground state is highly entangled. Relaxation of the qubits is analyzed within a mean-field treatment. The second order phase transition is lost, while new bistable regimes occur.Comment: 5 pages, 2 figure

Laser mass spectrometry for DNA sequencing, disease diagnosis, and fingerprinting

Since laser mass spectrometry has the potential for achieving very fast DNA analysis, the authors recently applied it to DNA sequencing, DNA typing for fingerprinting, and DNA screening for disease diagnosis. Two different approaches for sequencing DNA have been successfully demonstrated. One is to sequence DNA with DNA ladders produced from Snager`s enzymatic method. The other is to do direct sequencing without DNA ladders. The need for quick DNA typing for identification purposes is critical for forensic application. The preliminary results indicate laser mass spectrometry can possibly be used for rapid DNA fingerprinting applications at a much lower cost than gel electrophoresis. Population screening for certain genetic disease can be a very efficient step to reducing medical costs through prevention. Since laser mass spectrometry can provide very fast DNA analysis, the authors applied laser mass spectrometry to disease diagnosis. Clinical samples with both base deletion and point mutation have been tested with complete success