Imaging and modeling the ionospheric airglow response over Hawaii to the tsunami generated by the Tohoku earthquake of 11 March 2011

Although only centimeters in amplitude over the open ocean, tsunamis can generate appreciable wave amplitudes in the upper atmosphere, including the naturally occurring chemiluminescent airglow layers, due to the exponential decrease in density with altitude. Here, we present the first observation of the airglow tsunami signature, resulting from the 11 March 2011 Tohoku earthquake off the eastern coast of Japan. These images are taken using a wide-angle camera system located at the top of the Haleakala Volcano on Maui, Hawaii. They are correlated with GPS measurements of the total electron content from Hawaii GPS stations and the Jason-1 satellite. We find waves propagating in the airglow layer from the direction of the earthquake epicenter with a velocity that matches that of the ocean tsunami. The first ionospheric signature precedes the modeled ocean tsunami generated by the main shock by approximately one hour. These results demonstrate the utility of monitoring the Earth's airglow layers for tsunami detection and early warning

Metabolic regulation of pluripotency and germ cell fate through alpha-ketoglutarate.

An intricate link is becoming apparent between metabolism and cellular identities. Here, we explore the basis for such a link in an in vitro model for early mouse embryonic development: from naive pluripotency to the specification of primordial germ cells (PGCs). Using single-cell RNA-seq with statistical modelling and modulation of energy metabolism, we demonstrate a functional role for oxidative mitochondrial metabolism in naive pluripotency. We link mitochondrial tricarboxylic acid cycle activity to IDH2-mediated production of alpha-ketoglutarate and through it, the activity of key epigenetic regulators. Accordingly, this metabolite has a role in the maintenance of naive pluripotency as well as in PGC differentiation, likely through preserving a particular histone methylation status underlying the transient state of developmental competence for the PGC fate. We reveal a link between energy metabolism and epigenetic control of cell state transitions during a developmental trajectory towards germ cell specification, and establish a paradigm for stabilizing fleeting cellular states through metabolic modulation