Relationship of global assessment of change to AUSCAN and pinch and grip strength among individuals with hand osteoarthritis

SummaryObjectiveThis study assessed the utility and construct validity of a new patient global assessment of symptom change for hand osteoarthritis (OA) by examining its associations with change over time in grip strength, pinch strength, and AUStralian CANadian Osteoarthritis Hand Index (AUSCAN).MethodsParticipants (N=531, 80% female, mean age=68) were part of a study on the Genetics of Generalized Osteoarthritis (GOGO) and completed two assessments (average 4 years apart). At the second assessment, participants described change in their right and left hand pain, aching, and stiffness on a 15-point scale with descriptors ranging from “Great deal worse” to “Great deal better”. Linear regression models examined associations of global change scores with changes in hand strength and AUSCAN, controlling for age, gender, number of hand joints with OA, and time between assessments.ResultsBoth right and left hand global assessment of change scores were significantly associated with change in AUSCAN, grip strength, and right hand pinch strength (P<0.05), and approached significance for left hand pinch strength (P=0.06). The strongest associations were between global change scores and AUSCAN change (right hand: β=0.29, P<0.001; left hand: β=0.27, P<0.001). Associations of change scores with grip and pinch strength were stronger among participants with greater radiographic OA severity at baseline.ConclusionResults support the validity of this new global assessment of symptom change. This measure is particularly useful for assessing change over time when no baseline data are available. Additional research should examine this measure's responsiveness in the context of clinical trials

Scattering of particles by neutron stars: Time-evolutions for axial perturbations

The excitation of the axial quasi-normal modes of a relativistic star by scattered particles is studied by evolving the time dependent perturbation equations. This work is the first step towards the understanding of more complicated perturbative processes, like the capture or the scattering of particles by rotating stars. In addition, it may serve as a test for the results of the full nonlinear evolution of binary systems.Comment: 7 pages, 5 figures, Phys. Rev. D in pres

Relationship of limb length inequality with radiographic knee and hip osteoarthritis

SummaryObjectiveThis study examined the relationship of limb length inequality (LLI) with radiographic hip and knee osteoarthritis (OA) in a large, community-based sample.MethodsThe total study group comprised 926 participants with radiographic knee OA, 796 with radiographic hip OA, and 210 (6.6%) with LLI ≥2cm. The presence of radiographic OA was defined as Kellgren/Lawrence (K/L) grade ≥2. Multiple logistic regression models were used to examine the relationship of LLI with hip and knee OA, while controlling for age, gender, race, body mass index, and history of hip or knee problems (joint injury, fracture, surgery, or congenital anomalies).ResultsIn unadjusted analyses, participants with LLI were more likely than those without LLI to have radiographic knee OA (45.1% vs 28.3%, P<0.001) and radiographic hip OA (35.2% vs 28.7%, P=0.063). In multiple logistic regression models, knee OA was significantly associated with presence of LLI (adjusted Odds Ratio [aOR]=1.80, 95% Confidence Interval [95% CI] 1.29–2.52), but there was no significant relationship between hip OA and LLI (aOR=1.20, 95% CI 0.86–1.67). Among participants with LLI, right hip OA was more common when the contralateral limb was longer than when the ipsilateral limb was longer (30.3% vs 17.5%, P=0.070).ConclusionLLI was associated with radiographic knee OA, controlling for other important variables. Future research should examine the relationship of LLI with hip or knee OA incidence, progression, and symptom severity, as well as the efficacy for LLI corrective treatments in OA

Gaps in appropriate use of treatment strategies in osteoarthritis

Optimal management of osteoarthritis (OA) requires a combination of therapies, with behavioral (e.g., exercise and weight management) and rehabilitative components at the core, accompanied by pharmacological treatments and, in later stages, consideration of joint replacement surgery. Although multiple sets of OA treatment guidelines have been developed, there are gaps in the implementation of these recommendations. Key areas of concern include the underuse of exercise, weight management, and other behavioral and rehabilitation strategies as well as the overuse of opioid analgesics. In this review, we describe the major categories of treatment strategies for OA, including self-management, physical activity, weight management, physical therapy and other rehabilitative therapies, pharmacotherapies, and joint replacement surgery. For each category, we discuss the current evidence base to report on appropriate use, data regarding adherence to treatment recommendations, and potential approaches to optimize use. © 201

UB Knightlines Spring 2016

The UB Knightlines newsletter for spring of 2016. This issue contains articles discussing the heart of the city storytelling series, SASD student Erin LaFavor’s story of entrepreneurship, two UB alumni being awarded teaching awards, alumnus Jim Ford honored at White House for STEM education, UB chaplain leading an interfaith prayer vigil, UB model UN team’s win at the National Model United Nations Europe Conference, SASD students exhibiting at book fair at Yale, UB students win the Connecticut Space Grant, UB seminar on image, perception, and self-perception, a new scholarship to at risk students, UB and the Connecticut Technology Council host a programming challenge, a new Student Entrepreneur Center opens its doors, UB student volunteering during Martin Luther King Jr. Day, emeritus professor Richard Allen’s appearance on Prairie Home Companion, faculty news, alumni news, books published by alums and faculty, an African-American alumni reunion, and other campus and sports news

Cosmic String Cusps with Small-Scale Structure: Their Forms and Gravitational Waveforms

We present a method for the introduction of small-scale structure into strings constructed from products of rotation matrices. We use this method to illustrate a range of possibilities for the shape of cusps that depends on the properties of the small-scale structure. We further argue that the presence of structure at cusps under most circumstances leads to the formation of loops at the size of the smallest scales. On the other hand we show that the gravitational waveform of a cusp remains generally unchanged; the primary effect of small-scale structure is to smooth out the sharp waveform emitted in the direction of cusp motion.Comment: RevTeX, 8 pages. Replaced with version accepted for publication by PR

Is tissue engineering of the TMJ disc a feasible process?

Temporomandibular joint (TMJ) disorders are common and difficult to remedy. Tissue engineering is one alternative that seeks to improve TMJ sugical treatment options. Tissue engineering aims to replace diseased or injured tissue with biologically engineered constructs. These constructs should reproduce native function and limit an immune response. To achieve tissue engineering success, it is important to first understand the tissue's cellular, biochemical and mechanical properties in order to create validation and design criteria. Reviewd herein are the known properties of the TMJ disc and initial attempts toward TMJ disc tissue engineering. Important aspects of tissue engineering are scaffold selection, cell source, biochemical factors, and mechanical stimuli

Racial/Ethnic, Socioeconomic, and Geographic Disparities in the Epidemiology of Knee and Hip Osteoarthritis

It is estimated that 32.5 million US adults have clinical osteoarthritis (OA), with the most common sites being knee and hip. OA is associated with substantial individual and societal costs. Race/ethnicity, socioeconomic status (SES), and geographic variations in the prevalence of knee and hip OA are well established around the world. In addition, clinical outcomes associated with hip and knee OA differ according to race/ethnicity, SES, and geography. This variation is likely multifactorial and may also reflect country-specific differences in health care systems. The interplay between different factors, such as geography, SES, and race/ethnicity, is difficult to study

Polarized Dirac fermions in de Sitter spacetime

The tetrad gauge invariant theory of the free Dirac field in two special moving charts of the de Sitter spacetime is investigated pointing out the operators that commute with the Dirac one. These are the generators of the symmetry transformations corresponding to isometries that give rise to conserved quantities according to the Noether theorem. With their help the plane wave spinor solutions of the Dirac equation with given momentum and helicity are derived and the final form of the quantum Dirac field is established. It is shown that the canonical quantization leads to a correct physical interpretation of the massive or massless fermion quantum fields.Comment: 19 pages, LaTeX w AMS sym

Radiation tails and boundary conditions for black hole evolutions

In numerical computations of Einstein's equations for black hole spacetimes, it will be necessary to use approximate boundary conditions at a finite distance from the holes. We point out here that ``tails,'' the inverse power-law decrease of late-time fields, cannot be expected for such computations. We present computational demonstrations and discussions of features of late-time behavior in an evolution with a boundary condition.Comment: submitted to Phys. Rev.