206 research outputs found
A Sarcoma at the Site of Previous Extravasation of Adriamycin
We report the case of a 66-year-old man presenting with a high-grade pleomorphic sarcoma at the left elbow 16 years after
the extravasation of adriamycin given for a malignant ifbrous histiocytoma of the tibia.We suggest that this sarcoma originated
in a multistep way over many years, out of the chronic inflammatory tissue that developed due to a non-specific cellular
damage at the nuclear level, interfering with normal cell replication necessary for normal healing tissue healing. As a result,
the non-healed chronic inflammatory tissue transformed over several years into a preneoplastic mesenchymal tumour and
later into a high-grade pleomorphic sarcoma
EORTC Group Phase II Study of Oral Etoposide for Pretreated Soft Tissue Sarcoma
Purpose. This study investigates the efficacy and toxicity of daily oral etoposide in
chemotherapy for non-heavily pretreated advanced and metastatic soft tissue sarcoma (STS)
Tumor eligibility and response criteria for phase II and III studies and (sub)acute toxicity grading (with suggested amendments to the WHO criteria)
Tumor eligibility and response criteria for phase II and III studies and (sub) acute toxicity grading with suggested amendments to the WHO criteria
- …