544 research outputs found
Functional segregation and integration within the human subthalamic nucleus from a micro- and meso-level perspective
Mixed methodology in human brain research: integrating MRI and histology
Postmortem magnetic resonance imaging (MRI) can provide a bridge between histological observations and the in vivo anatomy of the human brain. Approaches aimed at the co-registration of data derived from the two techniques are gaining interest. Optimal integration of the two research fields requires detailed knowledge of the tissue property requirements for individual research techniques, as well as a detailed understanding of the consequences of tissue fixation steps on the imaging quality outcomes for both MRI and histology. Here, we provide an overview of existing studies that bridge between state-of-the-art imaging modalities, and discuss the background knowledge incorporated into the design, execution and interpretation of postmortem studies. A subset of the discussed challenges transfer to animal studies as well. This insight can contribute to furthering our understanding of the normal and diseased human brain, and to facilitate discussions between researchers from the individual disciplines
Probing the magnetic moment of FePt micromagnets prepared by Focused Ion Beam milling
We investigate the degradation of the magnetic moment of a 300 nm thick FePt
film induced by Focused Ion Beam (FIB) milling. A rod is milled out of a film by a FIB process and is attached
to a cantilever by electron beam induced deposition. Its magnetic moment is
determined by frequency-shift cantilever magnetometry. We find that the
magnetic moment of the rod is , which implies that 70% of the magnetic moment is preserved
during the FIB milling process. This result has important implications for atom
trapping and magnetic resonance force microscopy (MRFM), that are addressed in
this paper.Comment: 4 pages, 4 figure
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