Blood is thicker than water

This study represents a contribution to the pre-Colonial archaeology of the Windward Islands in the Caribbean. The research aimed to determine how the Ceramic Age (ca. 400 BC – AD 1492) Amerindian inhabitants of the region related to one another and others at various geographic scales, with a view to better understanding social interaction and organization within the Windward Islands as well the integration of this region within the macro-region. An island-by-island study of some 640 archaeological sites and their ceramic assemblages provided insight into settlement sequences, patterns and micro-mobility through time, besides highlighting various configurations of sites spread across different islands that were united by shared ceramic (decorative) traits. By extending the comparative scope of this research, possible material cultural influences from more distant regions could be suggested. While Windward Island communities certainly developed a localized material cultural identity, they remained open to a host of wide-ranging influences outside the Windward Island micro-region, flexibly realigning themselves particularly with numerous mainland South American communities in Late Ceramic Age times (ca. AD 700-1500)

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

The global burden of cancer attributable to risk factors, 2010-19 : a systematic analysis for the Global Burden of Disease Study 2019

Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4% (41.3-48.4) of all cancer deaths and 42.0% (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6% [47.8-54.1] of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% [32.5-41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% [27.9-42.8] and 33.3% [25.8-42.0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.Peer reviewe

The Science Performance of JWST as Characterized in Commissioning

This paper characterizes the actual science performance of the James Webb Space Telescope (JWST), as determined from the six month commissioning period. We summarize the performance of the spacecraft, telescope, science instruments, and ground system, with an emphasis on differences from pre-launch expectations. Commissioning has made clear that JWST is fully capable of achieving the discoveries for which it was built. Moreover, almost across the board, the science performance of JWST is better than expected; in most cases, JWST will go deeper faster than expected. The telescope and instrument suite have demonstrated the sensitivity, stability, image quality, and spectral range that are necessary to transform our understanding of the cosmos through observations spanning from near-earth asteroids to the most distant galaxies.Comment: 5th version as accepted to PASP; 31 pages, 18 figures; https://iopscience.iop.org/article/10.1088/1538-3873/acb29

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Blood is thicker than water: Amerindian intra- and inter-insular relationships and social organization in the pre-Colonial Windward Islands

This study represents a contribution to the pre-Colonial archaeology of the Windward Islands in the Caribbean. The research aimed to determine how the Ceramic Age (ca. 400 BC – AD 1492) Amerindian inhabitants of the region related to one another and others at various geographic scales, with a view to better understanding social interaction and organization within the Windward Islands as well the integration of this region within the macro region. This research approached the study of intra- and inter-island interaction and social development through an island-by-island study of some 640 archaeological sites and their ceramic assemblages. Besides providing insight into settlement sequences, patterns and micro mobility through time, it also highlighted various configurations of sites spread across different islands that were united by shared ceramic (decorative) traits. These configurations were more closely examined by taking recourse to graph theory. By extending the comparative scope of this research to the Greater Antilles and the South American mainland, possible material cultural influences from more distant regions could be suggested. While Windward Island communities certainly developed a localized material cultural identity, they remained open to a host of wide-ranging influences outside the Windward Island micro region. As such, rather than representing a cultural backwater operating in the periphery of a burgeoning Taíno empire, it is argued that Windward Island communities actively and flexibly realigned themselves with several mainland South American societies in Late Ceramic Age times (ca. AD 700-1500), forging and maintaining significant ties and exchange relationships

From Suazoid to folk pottery: pottery manufacturing traditions in a changing social and cultural environment on St. Lucia

Overview of pottery manufacturing traditions in St Lucia, placed within the island's cultural history from pre-Columbian times up to present Afro-Caribbean folk pottery. Authors focus on manufacturing processes in different cultural traditions through history, looking at raw materials used, the shaping and finishing, decoration, and firing process. First, they sketch St Lucia's habitation history since the first Amerindian settlers in 200 AD, and evidence of pottery, which climaxed in the later Suazoid period pottery since about 1150 AD, and discuss how later European colonization and arrival of Africans contributed to the decline of Amerindian traditions, replaced by European and West African pottery traditions, although some Amerindian traditions remained. The pottery manufacturing of 3 main cultural traditions are examined, discussing differences, as well as similarities due to cultural blending: Suazoid pottery, later Amerindian Island Carib pottery, with origins in the Guianas region, related to the Kar'ina, and current St Lucian, West African-influenced, "folk pottery". Authors conclude that all 3 traditions mainly use local clay, and include hand-built and low-fired pottery. Shaping techniques include coiling, and in today's pottery also fashioning with smaller lumps. Surfaces are smooth and polished in today's pottery, but more scraped and scratched in Suazoid vessels. Further, they find that decoration is uncommon in today's pottery, while Suazoid ceramics included decorations, and that vessel shapes tend to be simple in all 3 traditions. They also find that women have been the principal potters through time, although pottery was a male activity among the Island Caribs in the mid-17th c

Two-pore-domain K+ channels are a novel target for the anesthetic gases xenon, nitrous oxide, and cyclopropane.

Nitrous oxide, xenon, and cyclopropane are anesthetic gases that have a distinct pharmacological profile. Whereas the molecular basis for their anesthetic actions remains unclear, they behave very differently to most other general anesthetics in that they have little or no effect on GABAA receptors, yet strongly inhibit the N-methyl-d-aspartate subtype of glutamate receptors. Here we show that certain members of the two-pore-domain K+ channel superfamily may represent an important new target for these gaseous anesthetics. TREK-1 is markedly activated by clinically relevant concentrations of nitrous oxide, xenon, and cyclopropane. In contrast, TASK-3, a member of this family that is very sensitive to volatile anesthetics, such as halothane, is insensitive to the anesthetic gases. We demonstrate that the C-terminal cytoplasmic domain is not an absolute requirement for the actions of the gases, although it clearly plays an important modulatory role. Finally, we show that Glu306, an amino acid that has previously been found to be important in the modulation of TREK-1 by arachidonic acid, membrane stretch and internal pH, is critical for the activating effects of the anesthetic gases

A carbon monitoring system for mapping regional, annual aboveground biomass across the northwestern USA

This paper presents a prototype Carbon Monitoring System (CMS) developed to produce regionally unbiased annual estimates of aboveground biomass (AGB). Our CMS employed a bottom-up, two-step modeling strategy beginning with a spatially and temporally biased sample: project datasets collected and contributed by US Forest Service (USFS) and other forestry stakeholders in 29 different project areas in the northwestern USA. Plot-level AGB estimates collected in the project areas served as the response variable for predicting AGB primarily from lidar metrics of canopy height and density (R ^2 = 0.8, RMSE = 115 Mg ha ^−1 , Bias = 2 Mg ha ^−1 ). This landscape model was used to map AGB estimates at 30 m resolution where lidar data were available. A stratified random sample of AGB pixels from these landscape-level AGB maps then served as training data for predicting AGB regionally from Landsat image time series variables processed through LandTrendr. In addition, climate metrics calculated from downscaled 30 year climate normals were considered as predictors in both models, as were topographic metrics calculated from elevation data; these environmental predictors allowed AGB estimation over the full range of observations with the regional model (R ^2 = 0.8, RMSE = 152 Mg ha ^−1 , Bias = 9 Mg ha ^−1 ), including higher AGB values (>400 Mg ha ^−1 ) where spectral predictors alone saturate. For both the landscape and regional models, the machine-learning algorithm Random Forests (RF) was consistently applied to select predictor variables and estimate AGB. We then calibrated the regional AGB maps using field plot data systematically collected without bias by the national Forest Inventory and Analysis (FIA) Program. We found both our project landscape and regional, annual AGB estimates to be unbiased with respect to FIA estimates (Biases of 1% and 0.7%, respectively) and conclude that they are well suited to inform forest management and planning decisions by our contributing stakeholders. Social media abstract Lidar-based biomass estimates can be upscaled with Landsat data to regionally unbiased annual maps