Accessing elite nurses for research: reflections on the theoretical and practical issues of telephone interviewing

Elite groups are interesting as they frequently are powerful (in terms of position, knowledge and influence) and enjoy considerable authority. It is important, therefore, to involve them in research concerned with understanding social contexts and processes. This is particularly pertinent in healthcare, where considerable strategic development and change are features of everyday practice that may be guided or perceived as being guided, by elites. This paper evolved from a study investigating the availability and role of nurses whose remit involved leading nursing research and development within acute NHS Trusts in two health regions in Southern England. The study design included telephone interviews with Directors of Nursing Services during which time the researchers engaged in a reflective analysis of their experiences of conducting research with an `elite' group. Important issues identified were the role of gatekeepers, engagement with elites and the use of the telephone interview method in this context. The paper examines these issues and makes a case for involving executive nurses in further research. The paper also offers strategies to help researchers design and implement telephone interview studies successfully to maximise access to the views and experiences of `hard to reach groups', such as elites, while minimising the associated disruption

Allanite U–Pb dating places new constraints on the high‐pressure to high‐temperature evolution of the deep Himalayan crust

During continental collision, crustal rocks are buried, deformed, transformed and exhumed. The rates, timescales and tectonic implications of these processes are constrained through the sequence and conditions of metamorphic reactions in major and accessory phases. Petrographic, isotopic and elemental data from metabasite samples in NW Bhutan, eastern Himalaya, suggest initial equilibration under high-pressure (plagioclase-absent and rutile-present) conditions, followed by decompression to lower pressure conditions at high-temperatures that stabilized plagioclase, orthopyroxene and ilmenite. Field observations and chemical indicators suggest equilibration under the lower pressure conditions is likely linked to the infiltration of melt from the host metasedimentary rocks. The metabasites preserve two metamorphic growth stages of chemically-and petrographically distinct allanite that temporally overlap two stages of zircon growth. Allanite cores and zircon mantles grew at c. 19 ± 2 and 17–15.5 Ma respectively, linked texturally and chemically to the high-pressure evolution. Symplectitic rims on embayed allanite cores, wholly symplectized Aln–Ilm and Aln–Cpx grains, and high U zircon rims grew at c. 15.5–14.5 Ma, linked chemically to the presence of melt and lower pressure, high-temperature conditions. A single garnet Lu–Hf date is interpreted as geologically meaningless, with the bulk rock composition modified by melt infiltration after garnet formation. The open system evolution of these rocks precludes precise determination of the reactive bulk composition during metamorphic evolution and thus absolute conditions, especially during the early high-pressure evolution. Despite these limitations, we show that combined geochemical and petrographic datasets are still able to provide insights into the rates and timescales of deep orogenic processes. The data suggest a younger and shallower evolution for the NW Bhutan metabasites compared to similar rocks in the central and eastern Himalayas

TALPID3/KIAA0586 Regulates Multiple Aspects of Neuromuscular Patterning During Gastrointestinal Development in Animal Models and Human

TALPID3/KIAA0586 is an evolutionary conserved protein, which plays an essential role in protein trafficking. Its role during gastrointestinal (GI) and enteric nervous system (ENS) development has not been studied previously. Here, we analyzed chicken, mouse and human embryonic GI tissues with TALPID3 mutations. The GI tract of TALPID3 chicken embryos was shortened and malformed. Histologically, the gut smooth muscle was mispatterned and enteric neural crest cells were scattered throughout the gut wall. Analysis of the Hedgehog pathway and gut extracellular matrix provided causative reasons for these defects. Interestingly, chicken intra-species grafting experiments and a conditional knockout mouse model showed that ENS formation did not require TALPID3, but was dependent on correct environmental cues. Surprisingly, the lack of TALPID3 in enteric neural crest cells (ENCC) affected smooth muscle and epithelial development in a non-cell-autonomous manner. Analysis of human gut fetal tissues with a KIAA0586 mutation showed strikingly similar findings compared to the animal models demonstrating conservation of TALPID3 and its necessary role in human GI tract development and patterning

Klotho gene polymorphism, brain structure and cognition in early-life development

Variation in the klotho gene is linked to differences in health outcomes: klotho allele KL-VS heterozygosity is associated with longevity, better cognition and greater right frontal grey matter volume in late life. Contradicting reports, however, suggest that KL-VS’s effect on health might be age-dependent. Here we examine the relationship between KL-VS genotype, cognition and brain structure in childhood and adolescence. We hypothesized that KL-VS has early influences on cognitive and brain development. We investigated the associations of KL-VS carrier status with cognition and brain morphology in a cohort of 1387 children and adolescents aged 3–21 years, examining main effects and interactions between age, sex and socioeconomic circumstance. KL-VS had no main effect on either cognition or brain structure, though there was a significant KL-VS × age interaction for cognition (specifically executive function, attention, episodic memory, and general cognition), total grey matter and total brain volume. KL-VS heterozygotes had better cognition than non-carriers before age 11, but lower cognition after age 11. Heterozygotes had smaller brains than non-carriers did in early childhood. Sex moderated the association between KL-VS and white matter volume. Among girls, KL-VS heterozygotes had smaller white matter volumes than non-carriers. Among boys, heterozygotes had greater white matter volumes than non-carriers. However, a replication in a cohort of 2306 children aged 6–12 years showed no significant associations. In contrast to findings in late life, these results show that KL-VS does not have a main effect on cognition and brain structure. Furthermore, KL-VS’s influence may depend on age and sex

Timing and conditions of peak metamorphism and cooling across the Zimithang Thrust, Arunachal Pradesh, India

The Zimithang Thrust juxtaposes two lithotectonic units of the Greater Himalayan Sequence in Arunachal Pradesh, NE India. Monazite U–Pb, muscovite 40Ar/39Ar and thermobarometric data from rocks in the hanging and footwall constrain the timing and conditions of their juxtaposition across the structure, and their subsequent cooling. Monazite grains in biotite–sillimanite gneiss in the hanging wall yield LA-ICP-MS U–Pb ages of 16 ± 0.2 to 12.7 ± 0.4 Ma. A schistose gneiss within the high strain zone yields overlapping-to-younger monazite ages of 14.9 ± 0.3 to 11.5 ± 0.3 Ma. Garnet–staurolite–mica schists in the immediate footwall yield older monazite ages of 27.3 ± 0.6 to 17.1 ± 0.2 Ma. Temperature estimates from Ti-in-biotite and garnet–biotite thermometry suggest similar peak temperatures were achieved in the hanging and footwalls (~ 525–650 °C). Elevated temperatures of ~ 700 °C appear to have been reached in the high strain zone itself and in the footwall further from the thrust. Single grain fusion 40Ar/39Ar muscovite data from samples either side of the thrust yield ages of ~ 7 Ma, suggesting that movement along the thrust juxtaposed the two units by the time the closure temperature of Ar diffusion in muscovite had been reached. These data confirm previous suggestions that major orogen-parallel out-of-sequence structures disrupt the Greater Himalayan Sequence at different times during Himalayan evolution, and highlight an eastwards-younging trend in 40Ar/39Ar muscovite cooling ages at equivalent structural levels along Himalayan strike

Expanding Clinical Presentations Due to Variations in THOC2 mRNA Nuclear Export Factor

Multiple TREX mRNA export complex subunits (e.g., THOC1, THOC2, THOC5, THOC6, THOC7) have now been implicated in neurodevelopmental disorders (NDDs), neurodegeneration and cancer. We previously implicated missense and splicing-defective THOC2 variants in NDDs and a broad range of other clinical features. Here we report 10 individuals from nine families with rare missense THOC2 variants including the first case of a recurrent variant (p.Arg77Cys), and an additional individual with an intragenic THOC2 microdeletion (Del-Ex37-38). Ex vivo missense variant testing and patient-derived cell line data from current and published studies show 9 of the 14 missense THOC2 variants result in

Understanding and managing identification uncertainty of close modes in operational modal analysis

This is the final version. Available on open access from Elsevier via the DOI in this record.Close modes are much more difficult to identify than well-separated modes and their identification (ID) results often have significantly larger uncertainty or variability. The situation becomes even more challenging in operational modal analysis (OMA), which is currently the most economically viable means for obtaining in-situ dynamic properties of large civil structures and where ID uncertainty management is most needed. To understand ID uncertainty and manage it in field test planning, this work develops the ‘uncertainty law’ for close modes, i.e., closed form analytical expressions for the remaining uncertainty of modal parameters identified using output-only ambient vibration data. The expressions reveal a fundamental definition that quantifies ‘how close is close’ and demystify the roles of various governing factors. The results are verified with synthetic, laboratory and field data. Statistics of governing factors from field data reveal OMA challenges in different situations, now accountable within a coherent probabilistic framework. Recommendations are made for planning ambient vibration tests taking close modes into account. Up to modelling assumptions and the use of probability, the uncertainty law dictates the achievable precision of modal properties regardless of the ID algorithm used. The mathematical theory behind the results in this paper is presented in a companion paper.Engineering and Physical Sciences Research Council (EPSRC

Search for displaced vertices arising from decays of new heavy particles in 7 TeV pp collisions at ATLAS

We present the results of a search for new, heavy particles that decay at a significant distance from their production point into a final state containing charged hadrons in association with a high-momentum muon. The search is conducted in a pp-collision data sample with a center-of-mass energy of 7 TeV and an integrated luminosity of 33 pb^-1 collected in 2010 by the ATLAS detector operating at the Large Hadron Collider. Production of such particles is expected in various scenarios of physics beyond the standard model. We observe no signal and place limits on the production cross-section of supersymmetric particles in an R-parity-violating scenario as a function of the neutralino lifetime. Limits are presented for different squark and neutralino masses, enabling extension of the limits to a variety of other models.Comment: 8 pages plus author list (20 pages total), 8 figures, 1 table, final version to appear in Physics Letters

Measurement of the polarisation of W bosons produced with large transverse momentum in pp collisions at sqrt(s) = 7 TeV with the ATLAS experiment

This paper describes an analysis of the angular distribution of W->enu and W->munu decays, using data from pp collisions at sqrt(s) = 7 TeV recorded with the ATLAS detector at the LHC in 2010, corresponding to an integrated luminosity of about 35 pb^-1. Using the decay lepton transverse momentum and the missing transverse energy, the W decay angular distribution projected onto the transverse plane is obtained and analysed in terms of helicity fractions f0, fL and fR over two ranges of W transverse momentum (ptw): 35 < ptw < 50 GeV and ptw > 50 GeV. Good agreement is found with theoretical predictions. For ptw > 50 GeV, the values of f0 and fL-fR, averaged over charge and lepton flavour, are measured to be : f0 = 0.127 +/- 0.030 +/- 0.108 and fL-fR = 0.252 +/- 0.017 +/- 0.030, where the first uncertainties are statistical, and the second include all systematic effects.Comment: 19 pages plus author list (34 pages total), 9 figures, 11 tables, revised author list, matches European Journal of Physics C versio