A Longitudinal Flap of Vena Cava in Live Donor a Safe Option for Adding Elongation at Least 10mm in Vein of Right Kidney

Introduction: To treat chronic kidney, kidney transplantation is the most efficient way especially when donor is alive, in such a way that survival tie can be increased in the best possible way. In this regard, major problem is short renal vein resulting in thrombosis. To elongate the vein length, there is a technique that we report in this study. Materials and Methods: The technique of interest is that at the time of dissection of vena cava and renal vein, it should be tried to put vein of vena cava 1cm above and 1cm below of renal vein. In addition, the kidney must be placed in right iliac of kidney done. Results: Patients discharged in good condition after two days. In our cases, there was no tension in the site of anastomosis showing safe condition. Conclusion: Longitudinal flap of vena cava accompanied by a suitable cuff can increase about I cm length of renal vein

Genome-scale gene/reaction essentiality and synthetic lethality analysis

Synthetic lethals are to pairs of non-essential genes whose simultaneous deletion prohibits growth. One can extend the concept of synthetic lethality by considering gene groups of increasing size where only the simultaneous elimination of all genes is lethal, whereas individual gene deletions are not. We developed optimization-based procedures for the exhaustive and targeted enumeration of multi-gene (and by extension multi-reaction) lethals for genome-scale metabolic models. Specifically, these approaches are applied to iAF1260, the latest model of Escherichia coli, leading to the complete identification of all double and triple gene and reaction synthetic lethals as well as the targeted identification of quadruples and some higher-order ones. Graph representations of these synthetic lethals reveal a variety of motifs ranging from hub-like to highly connected subgraphs providing a birds-eye view of the avenues available for redirecting metabolism and uncovering complex patterns of gene utilization and interdependence. The procedure also enables the use of falsely predicted synthetic lethals for metabolic model curation. By analyzing the functional classifications of the genes involved in synthetic lethals, we reveal surprising connections within and across clusters of orthologous group functional classifications

Which one is prefer and safe in auto transplantation for Repairing of full length complete avulsed ureter, immediately or delayed?

Introduction: In modern medicine in the field of urology, sometimes some techniques result in awful complications such as ureter strictures and complete avulsion. Case presentation: In this case series, we report four cases including a male and 3 female patients (age range: 55-80 years) who developed complete ureters avulsion during transurethral lithotripsy. The main action that has been done was autotransplant. All four patients discharged in good condition six days after surgery. At the time of discharge, no one had severe complications. Conclusion: As observed, repairing complete ureter avulsion can be considered as a safe and suitable procedure after complete evaluation