Clinical significance of circulating tumor cell related markers in patients with epithelial ovarian cancer before and after adjuvant chemotherapy

Acknowledgment This study was financially supported by grants from Mashhad University of Medical Sciences (No. 961802) and National Institute for Medical Research Development (NIMAD) (No. 973128).Peer reviewedPublisher PD

Downregulation of Caspase 8 in a group of Iranian breast cancer patients – A pilot study

Acknowledgments Author contributions: MA performed related laboratory work, helped with sample collection, analysed the data and drafted the manuscript. ND and FAJ helped with sample collection and laboratory work. ASF and MG confirmed the diagnosis and provided the appropriate specimens. AP conceived and designed the study, supervised the project and edited the manuscript. The authors would like to thank the research council of Mashhad University of Medical Sciences, Mashhad, Iran for the financial support (Grant Number: 940936).Peer reviewedPublisher PD

Antioxidant and toxicity studies of biosynthesized cerium oxide nanoparticles in rats

Funding Information: We would like to thank the Vice Chancellery for Research and Technology, MUMS for financial support (grant no 930954) and facilities.Peer reviewedPublisher PD

Design, construction and evaluation of 1a/JFH1 HCV chimera by replacing the intergenotypic variable region

Peer reviewedPublisher PD

Whole exome sequencing and homozygosity mapping reveals genetic defects in consanguineous Iranian families with inherited retinal dystrophies

Acknowledgements This research was funded by the Swiss National Science Foundation (Grant #176097 to CR). We would like to express gratitude to the patients and all their family members that participated in this study for their valuable cooperation and participation.Peer reviewedPublisher PD

Expression of Pro-Apoptotic Bax and Anti-Apoptotic Bcl-2 Proteins in Hydatidiform Moles and Placentas With Hydropic Changes

Morphologic examination still forms the main diagnostic tool in the differential diagnosis of molar placentas. However the criteria are subjective and show considerable inter-observer variability among pathologists. The aim of the present study was to investigate the role of Bcl-2 and Bax immunostaining in the differential diagnosis of molar placentas. Bax and Bcl-2 immunohistochemical staining were performed in 19 molars (8 partial and 11 complete hydatidiform mole) and 10 non-molar (hydropic abortion) formalin-fixed, paraffin-embedded tissue samples. Ploidy analysis using flow cytometry had confirmed diploidy in hydropic abortions and complete hydatidiform moles and triploidy in partial hydatidiform moles. Bcl-2 expression was observed only in syncytiotrophoblasts, No immunoreactivity was detected in Cytotrophoblasts, and stromal cells, the total score averages of Bcl-2 immunoexpression in partial hydatidiform moles and hydropic abortions were significantly higher than in complete hydatidiform moles, whereas no significant difference was observed between partial hydatidiform moles and hydropic abortions. Bax immunoreactivity was observed in cytotrophoblasts, stromal cells and occasionally in syncytiotrophoblasts. No statistically significant difference in Bax immunoexpression total score was observed among various groups. Based on the results of this study, Bcl-2 immunostaining offers a potential adjunctive diagnostic tool to distinguish complete hydatidiform mole from partial hydatidiform mole and hydropic abortion, but not partial hydatidiform mole from hydropic abortion, Bax immunostaining cannot be helpful in this regard

A novel causative functional mutation in GATA6 gene is responsible for familial dilated cardiomyopathy as supported by in silico functional analysis

Funding Information: This study was supported by grants from the Mashhad University of Medical Sciences (Grant Number 980955). The authors thank the management of advanced computational centre, Khayyam Innovation Ecosystem, Mashhad, Iran for providing the facilities and encouragement to carry out this research work.Peer reviewedPublisher PD

Secondary findings from whole-exome sequencing data in families with familial combined hyperlipidemia (FCHL)

Acknowledgements The grant of this study was paid by Mashhad University of Medical Sciences, Mashhad, Iran. Funding This study was funded by Mashhad University of Medical Sciences.Peer reviewedPublisher PD

The Dilemma of TP53 Codon 72 Polymorphism (rs1042522) and Breast Cancer Risk : A Case-Control Study and Meta-Analysis in The Iranian Population

The authors would like to thank all participants in this research. We would also like to thank Mashhad University of Medical Sciences and Omid Hospital (Mashhad, Iran) for their support to the project. This work was financially supported by Mashhad University of Medical Sciences under Grant No. 930891. No potential conflict of interest was reported by the authors.Peer reviewedPublisher PD