Desde la Promoción de Salud Mental hacia la Producción de Salud

La ponencia parte de la problematización de la noción de Salud Mental a la luz del paradigma que sustenta una concepción integral del proceso salud enfermedad; así como también de la de Salud Mental Comunitaria que emerge a mediados del pasado siglo como consecuencia de la crisis de una psicología centrada en el individuo y en la enfermedad. En la medida que el origen de la Psicología Comunitaria esté ligado a este movimiento, se analiza cómo aún hoy persiste una concepción del abordaje comunitario en el desarrollo de programas sociales dirigidos a poblaciones en situación de pobreza, ligado a la intervención en el entorno inmediato de los sujetos (la co mu ni - dad) y en su re la ción con el mis mo

Development of a Proposed Community Action Plan for the Juvenile Diabetes Research Foundation

The Juvenile Diabetes Research Foundation (JDRF) is a national organization that was started back in 1970 by two mothers of sons with type 1 diabetes. Since its founding, JDRF has awarded more than $1.5 billion to diabetes research around the world, including$9.9 million of research in San Diego. JDRF is a volunteer-driven organization with thousands of volunteers in locations worldwide. While JDRF is working hard to find a cure and improve the lives of those living with type 1 diabetes, it also has a goal of providing volunteer-led support programs to people with type 1 diabetes and their families. JDRF San Diego is challenged with being able to provide outreach support to families in the South Bay area. Alicia Milla and Alexis Rodriguez developed a proposed Community Action Plan to assist the San Diego chapter of JDRF in becoming more responsive to the South Bay community.https://digital.sandiego.edu/npi-bpl-communityengagement/1001/thumbnail.jp

Biocontrol of mycotoxins: dynamics and mechanisms of action

This paper discusses the relationship between biocontrol agents (BCAs) and mycotoxigenic fungi and mycotoxin control. In most cases BCAs are examined for control of growth of fungal pathogens and disease symptoms. However, for mycotoxin control the approach and focus needs to be different. The mechanism of action and the inoculum dose necessary for control of toxin production by Aspegillus, Penicillium and Fusarium species may be different from that for traditional fungal plant pathogens. The mechanisms of action, the relative inoculum potential and the impact that interacting environmental conditions have on control of key components of the life cycle of mycotoxigenic fungi are considered. The practical aspects of production and formulation hurdles are discussed and potential future approaches and strategies which may need to be considered for more effective biocontrol of mycotoxigenic fungi and mycotoxins are presented

A fluorogenic, peptide-based probe for the detection of Cathepsin D in macrophages

Supplementary information The online version contains supplementary material available at https://doi.org/10.1038/s42004-023-01035-9Cathepsin D is a protease that is an effector in the immune response of macrophages, yet to date, only a limited number of probes have been developed for its detection. Herein, we report a water soluble, highly sensitive, pH insensitive fluorescent probe for the detection of Cathepsin D activity that provides a strong OFF/ON signal upon activation and with bright emission at 515 nm. The probe was synthesised using a combination of solid and solution-phase chemistries, with probe optimisation to increase its water solubility and activation kinetics by addition of a long PEG chain (5 kDa) at the C-terminus. A BODIPY fluorophore allowed detection of Cathepsin D across a wide pH range, important as the protease is active both at the low pH found in lysosomes and also in higher pH phagolysosomes, and in the cytosol. The probe was successfully used to detect Cathepsin D activity in macrophages challenged by exposure to bacteria.Engineering and Physical Sciences Research Council (EPSRC, UK) for Interdisciplinary Research Collaboration grants EP/R005257/1Medical Research Council SHIELD consortium grant MR/N02995X/

Moving into the red – a near infra-red optical probe for analysis of human neutrophil elastase in activated neutrophils and neutrophil extracellular traps

Neutrophils are the first immune cells recruited for defence against invading pathogens; however, their dysregulated activation and subsequent release of the enzyme human neutrophil elastase is associated with several, inflammation-based, diseases. Herein, we describe a FRET-based, tri-branched (one quencher, three fluorophores) near infrared probe that provides an intense OFF/ON amplified fluorescence signal for specific detection of human neutrophil elastase. The probe allowed selective detection of activated neutrophils and labelling of neutrophil extracellular traps. A tri-branched, FRET-based probe for the detection of hNE was synthesised with emission in the NIR region of the spectrum, where endogenous biomolecules have decreased absorbance, and minimal autofluorescenceUK Research & Innovation (UKRI) Engineering & Physical Sciences Research Council (EPSRC) EP/R005257/1UK Research & Innovation (UKRI) Medical Research Council UK (MRC) MR/N02995X/

Informal Learning with a Gender Perspective Transmitted by Influencers through Content on YouTube and Instagram in Spain

[Abstract] The struggle for gender equality is based on identifying, understanding, and eradicating the causes of inequality. Digital media are and have always been governed by men and, as a consequence, have become another instrument of patriarchy. This article analyses the content created on YouTube and Instagram by four of the most popular influencers in Spain in order to examine the presence of stereotypes and gender roles, the use of sexist or inclusive language, and the influencers’ level of social engagement on issues related to gender equality. A content analysis approach using ATLAS.ti 8 software was chosen, as this method provides information about the sender of the message as the well the message itself and its impact. The findings of the analysis show that influencers transmit sexist roles and stereotypes, use non-inclusive language, and exhibit no social engagement on questions of gender inequality. The study concludes by highlighting the importance of cyberfeminism as a way of promoting gender equality online

Evaluation of the risk of fungal spoilage when substituting sucrose with commercial purified Stevia glycosides in sweetened bakery products

The objectives of this study were to compare the effect of different Stevia-based sugar substitutes (S1–S3), sucrose alone and a mixture of sucrose + S1 on: (a) humectant properties, (b) relative colonisation rates of sponge cake slices at 0.90 aw by strains of Aspergillus flavus, Eurotium amstelodami, Fusarium graminearum and Penicillium verrucosum at 20 and 25 °C and (c) shelf-life periods in days prior to visible growth. Results showed that sucrose, S1 commercial sugar substitute and the mixture of sucrose + S1 in water solutions were able to reach water activity levels similar to those of glycerol and glucose mixtures. The S2 and S3 commercial sugar substitutes were unable to reduce aw levels significantly. At 25 °C, colonisation of sponge cake slices by E. amstelodami, A. flavus and P. verrucosum occurred in all the treatments. Growth of F. graminearum only occurred on sponge cake slices containing S2 and S3 Stevia-based products at both temperatures. The best control of growth (30 days) was achieved in cake slices modified with sucrose or S1 Stevia treatments inoculated with A. flavus and in the sucrose treatment for E. amstelodami at 20 °C. F. graminearum growth was completely inhibited when sucrose alone, S1 or sucrose + S1 treatments were used at both temperatures. This study suggests that, as part of a hurdle technology approach, replacing sucrose with low calorie sugar substitutes based on Stevia glycosides needs to be done with care. This is because different products may have variable humectant properties and bulking agents which may shorten the potential shelf-life of intermediate moisture bakery products