The Physical Nature of Rest-UV Galaxy Morphology During the Peak Epoch of Galaxy Formation

Motivated by the irregular and little-understood morphologies of z ~ 2 - 3 galaxies, we use non-parametric coefficents to quantify the morphologies of 216 galaxies which have been spectroscopically confirmed to lie at redshifts z = 1.8 - 3.4 in the GOODS-N field. Using measurements of ultraviolet (UV) and optical spectral lines, multi-band photometric data, and stellar population models we statistically assess possible correlations between galaxy morphology and physical observables such as stellar mass, star formation rate, and the strength of galaxy-scale outflows. We find evidence that dustier galaxies have more nebulous UV morphologies and that larger, more luminous galaxies may drive stronger outflows, but otherwise conclude that UV morphology is either statistically decoupled from the majority of physical observables or determined by too complex a combination of physical processes to provide characterizations with predictive power. Given the absence of strong correlations between UV morphology and physical parameters such as star formation rates, we are therefore unable to support the hypothesis that morphologically irregular galaxies predominantly represent major galaxy mergers. Comparing galaxy samples, we find that IR-selected BzK galaxies and radio-selected submillimeter galaxies (SMGs) have UV morphologies similar to the optically selected sample, while distant red galaxies (DRGs) are more nebulous.Comment: 26 pages. Accepted for publication in the ApJ. Version with full resolution figures is available at http://www.astro.caltech.edu/~drlaw/Papers/UVmorph.pd

Community-acquired pneumonia in children: cell-free plasma sequencing for diagnosis and management.

Community-acquired pneumonia (CAP) is a common cause of pediatric hospital admission. Empiric antibiotic therapy for hospitalized children with serious CAP now targets the most likely pathogen(s), including those that may demonstrate significant antibiotic resistance. Cell-free plasma next-generation sequencing (CFPNGS) was first made available for Pediatric Infectious Diseases physicians in June 1, 2017, to supplement standard-of-care diagnostic techniques. A retrospective chart review was performed for children hospitalized with CAP between June 1, 2017, and January 22, 2018, to evaluate the impact of CFPNGS. We identified 15 hospitalized children with CAP without other underlying medical conditions for whom CFPNGS was performed. CFPNGS identified a pathogen in 13 of 15 (86%) children compared with 47% for those using standard culture and PCR-based methods alone. Changes in antibiotic management were made in 7 of 15 (47%) of children as a result of CFPNGS

Transcriptional plasticity buffers genetic variation in zinc homeostasis

In roots of Arabidopsis thaliana, Zn can be either loaded into the xylem for translocation to the shoot or stored in vacuoles. Vacuolar storage is achieved through the action of the Zn/Cd transporter HMA3 (Heavy Metal Atpase 3). The Col-0 accession has an HMA3 loss-of-function allele resulting in high shoot Cd, when compared to accession CSHL-5 which has a functional allele and low shoot Cd. Interestingly, both Col-0 and CSHL-5 have similar shoot Zn concentrations. We hypothesize that plants sense changes in cytosolic Zn that are due to variation in HMA3 function, and respond by altering expression of genes related to Zn uptake, transport and compartmentalisation, in order to maintain Zn homeostasis. The expression level of genes known to be involved in Zn homeostasis were quantified in both wild-type Col-0 and Col-0::HMA3CSHL-5 plants transformed with the functional CSHL-5 allele of HMA3. We observed significant positive correlations between expression of HMA3 and of genes known to be involved in Zn homeostasis, including ZIP3, ZIP4, MTP1, and bZIP19. The results support our hypothesis that alteration in the level of function of HMA3 is counterbalanced by the fine regulation of the Zn homeostasis gene network in roots of A. thaliana

Seasonal patterns of oral antihistamine and intranasal corticosteroid purchases from Australian community pharmacies : a retrospective observational study

Acknowledgments The abstract of this paper was presented at the Respiratory Effectiveness Group 2016 Annual Summit as a poster presentation with interim findings. The poster’s abstract was published in “Poster Abstracts” in The Journal of Thoracic Disease (Vol. 8, Supplement 5, 5 July 2016). http://jtd.amegroups.com/article/view/8504.Peer reviewedPublisher PD

Morphologies of Galaxies in and around a Protocluster at z=2.300

We present results from the first robust investigation of galaxy morphology as a function of environment at z>1.5. Our study is motivated by the fact that star-forming galaxies contained within a protocluster at z=2.3 in the HS1700+64 field have significantly older ages and larger stellar masses on average than those at similar redshifts but more typical environmental densities. In the analysis of HST/ACS images, we apply non-parametric statistics to characterize the rest-frame UV morphologies of a sample of 85 UV-selected star-forming galaxies at z=1.7-2.9, 22 of which are contained in the protocluster. The remaining 63 control-sample galaxies are not in the protocluster but have a similar mean redshift of ~2.3. We find no environmental dependence for the distributions of morphological properties. Combining the measured morphologies with the results of population synthesis modeling, we find only weak correlations, if any, between morphological and stellar population properties such as stellar mass, age, extinction and star-formation rate. Given the incomplete census of the protocluster galaxy population, and the lack of correlation between rest-frame UV morphology and star-formation history at z~2 within our sample, the absence of environmental trends in the distribution of morphological properties is not surprising. Additionally, using a larger sample of photometric candidates, we compare morphological distributions for 282 UV-selected and 43 near-IR-selected galaxies. While the difference in the degree of nebulosity between the two samples appears to be a byproduct of the fainter average rest-frame UV surface brightness of the near-IR-selected galaxies, we find that, among the lowest surface brightness galaxies, the near-IR-selected objects have significantly smaller angular sizes (abridged).Comment: 25 pages including 16 figures. Accepted for publication in ApJ. Version with full resolution figures available at http://www.astro.princeton.edu/~apeter/LBG/papers/peter2007_fullres.ps.g

Managing clients’ expectations at the outset of online Cognitive Behavioural Therapy (CBT) for depression

Background\ud \ud Engaging clients in psychotherapy by managing their expectations is important for therapeutic success. Initial moments in first sessions of therapy are thought to afford an opportunity to establish a shared understanding of how therapy will proceed. However there is little evidence from analysis of actual sessions of therapy to support this.\ud \ud Objective\ud \ud This study utilised recordings to examine how therapists manage clients’ expectations during the first two sessions of online Cognitive Behavioural Therapy (CBT). \ud Methods Expectation management was investigated through conversation analysis of sessions from 176 client-therapist dyads involved in online CBT. The primary focus of analysis was expectation management during the initial moments of first sessions, with a secondary focus on expectations at subsequent points. \ud \ud Analysis\ud \ud Clients’ expectations for therapy were most commonly managed during the initial moments of first sessions of therapy. At this point, most therapists either outlined the tasks of the first and subsequent sessions (n=36), or the first session only (n=108). On other occasions (n = 32), no attempt was made to manage clients’ expectations by outlining what would happen in therapy. Observations of the interactional consequences of such an absence suggest clients may struggle to engage with the therapeutic process in the absence of appropriate expectation management by therapists. \ud \ud Conclusion\ud \ud Clients may more readily engage from the outset of therapy when provided with an explanation that manages their expectation of what is involved. Therapists can accomplish this by projecting how therapy will proceed, particularly beyond the initial session

Managing the therapeutic relationship in online cognitive behavioural therapy for depression:Therapists' treatment of clients' contributions

This article examines how therapists and clients manage the therapeutic relationship in online psychotherapy. Our study focuses on early sessions of therapy involving 22 therapist-client pairs participating in online Cognitive Behavioural Therapy (CBT) for depression. Using Conversation Analysis (CA), we examine how therapists can orient to clients’ contributions, while also retaining control of the therapeutic trajectory. We report two practices that therapists can use, at their discretion, following clients’ responses to requests for information. The first, thanking, accepts clients’ responses, orienting to the neutral affective valence of those responses. The second, commiseration, orients to the negative affective valence of clients’ responses. We argue that both practices are a means by which therapists can simultaneously manage developing rapport, while also retaining control of the therapeutic process

Integral Field Spectroscopy of High-Redshift Star Forming Galaxies with Laser Guided Adaptive Optics: Evidence for Dispersion-Dominated Kinematics

We present early results from an ongoing study of the kinematic structure of star-forming galaxies at redshift z ~ 2 - 3 using integral-field spectroscopy of rest-frame optical nebular emission lines in combination with Keck laser guide star adaptive optics (LGSAO). We show kinematic maps of 3 target galaxies Q1623-BX453, Q0449-BX93, and DSF2237a-C2 located at redshifts z = 2.1820, 2.0067, and 3.3172 respectively, each of which is well-resolved with a PSF measuring approximately 0.11 - 0.15 arcsec (~ 900 - 1200 pc at z ~ 2-3) after cosmetic smoothing. Neither galaxy at z ~ 2 exhibits substantial kinematic structure on scales >~ 30 km/s; both are instead consistent with largely dispersion-dominated velocity fields with sigma ~ 80 km/s along any given line of sight into the galaxy. In contrast, DSF2237a-C2 presents a well-resolved gradient in velocity over a distance of ~ 4 kpc with peak-to-peak amplitude of 140 km/s. It is unlikely that DSF2237a-C2 represents a dynamically cold rotating disk of ionized gas as the local velocity dispersion of the galaxy (sigma = 79 km/s) is comparable to the observed shear. Using extant multi-wavelength spectroscopy and photometry we relate these kinematic data to physical properties such as stellar mass, gas fraction, star formation rate, and outflow kinematics and consider the applicability of current galaxy formation models.[Abridged]Comment: 19 pages, 10 figures (5 color); accepted for publication in ApJ. Version with full-resolution figures is available at http://www.astro.caltech.edu/~drlaw/Papers/OSIRIS_data1.pd