Effect of melissa officinalis (Lemon balm) on sexual dysfunction in women: A double- blind, randomized, placebo-controlled study

Hypoactive sexual desire disorder (HSDD) is the most prevalent female sexual dysfunction (FSD) and its bio-psychosocial multifactorial etiology justifies its multifaceted treatment. In Persian Medicine (PM), the weakness of the main organs (heart, brain and liver) is one of the important causes of lack of sexual desire; hence, their strengthening is a priority during treatment. Melissa officinalis is one of the medicinal plants with tonic characteristics for the main organs in PM and was used for treatment in this study. The aim of the present study was to evaluate the efficacy and safety of M. officinalis in the improvement of HSDD in women. Eighty nine (89) eligible women suffering from decreased sexual desire were randomly assigned to groups. The participants received medication (500 mg of aqueous extract of M. officinalis) or placebo 2 times a day for 4 weeks. Changes in scores of desire, arousal, lubrication, orgasm, satisfaction and pain were evaluated at the end of 4 weeks of treatment using the Female Sexual Function Index (FSFI) questionnaire in the two groups. Forty three participants completed the study. The increase in desire (P < 0.001), arousal (P < 0.001), lubrication (P < 0.005), orgasm (P < 0.001), satisfaction (P < 0.001), pain (P < 0.002) and FSFI total score (P < 0.001) in the M. officinalis group was significantly more than that of the placebo group. The willingness to continue treatment was significantly higher in the M. officinalis as compared to the placebo group (P < 0.001). M. officinalis may be a safe and effective herbal medicine for the improvement of HSDD in women. © 2018 by School of Pharmacy Shaheed Beheshti University of Medical Sciences and Health Services

Effect of melissa officinalis (Lemon balm) on sexual dysfunction in women: A double- blind, randomized, placebo-controlled study

Hypoactive sexual desire disorder (HSDD) is the most prevalent female sexual dysfunction (FSD) and its bio-psychosocial multifactorial etiology justifies its multifaceted treatment. In Persian Medicine (PM), the weakness of the main organs (heart, brain and liver) is one of the important causes of lack of sexual desire; hence, their strengthening is a priority during treatment. Melissa officinalis is one of the medicinal plants with tonic characteristics for the main organs in PM and was used for treatment in this study. The aim of the present study was to evaluate the efficacy and safety of M. officinalis in the improvement of HSDD in women. Eighty nine (89) eligible women suffering from decreased sexual desire were randomly assigned to groups. The participants received medication (500 mg of aqueous extract of M. officinalis) or placebo 2 times a day for 4 weeks. Changes in scores of desire, arousal, lubrication, orgasm, satisfaction and pain were evaluated at the end of 4 weeks of treatment using the Female Sexual Function Index (FSFI) questionnaire in the two groups. Forty three participants completed the study. The increase in desire (P < 0.001), arousal (P < 0.001), lubrication (P < 0.005), orgasm (P < 0.001), satisfaction (P < 0.001), pain (P < 0.002) and FSFI total score (P < 0.001) in the M. officinalis group was significantly more than that of the placebo group. The willingness to continue treatment was significantly higher in the M. officinalis as compared to the placebo group (P < 0.001). M. officinalis may be a safe and effective herbal medicine for the improvement of HSDD in women. © 2018 by School of Pharmacy Shaheed Beheshti University of Medical Sciences and Health Services

Effective materia medica in treatment of insomnia in Iranian traditional medicine

مقدمه: بی‏خوابی یکی از شایع‌ترین اختلالات خواب است که می‏تواند بر روی خلق، هوشیاری، حافظه، امنیت و عملکرد روزانه فرد تأثیر بگذارد. در حال حاضر متداول‏ترین داروها در درمان بی‏خوابی گروه بنزودیازپین‏ها می‏باشند که شیوع عوارض جانبی در این گروه مانند اختلالات شناختی، وابستگی به دارو و برگشت علائم بیماری پس از قطع مصرف دارو استفاده از این داروها را محدود می‏کند، این امر لزوم بکارگیری درمان‌های کارآمد‏تر را ضروری می‏سازد. در طب سنتی ایران نیز به مقوله بی‏خوابی و درمان‌های آن به‏ طور گسترده‏ای پرداخته شده است. در این مطالعه مفردات مؤثر بر بی‏خوابی در منابع طب سنتی مورد بررسی قرار گرفته است. روش: این تحقیق، یک مطالعه کتابخانه‏ای و بررسی متون می‏باشد. در این مطالعه مفردات دارویی مؤثر در درمان بی‏خوابی، در 6 کتاب مرجع داروشناسی طب سنتی شامل «الابنیه عن حقایق الادویه»، «القانون فی الطب»، «ریاض الادویه»، «تذکره داوود انطاکی»، «تحفه حکیم مؤمن» و «مخزن‌ الادویه» جستجو شد. این مطالعه در چند مرحله (یافتن واژگان کلیدی، جستجو در منابع، تهیه لیست واحد، یافتن مترادفات، دسته‌بندی، جمع‌بندی و امتیازدهی، مرتب‌سازی بر حسب امتیاز کسب‌شده) انجام شد. یافته‌ها: 28 مفرده دارویی مطرح در درمان بی‏خوابی یافت شد که 25 مفرده منشأ گیاهی و 3 مفرده منشأ حیوانی دارند. این مفردات به ترتیب امتیاز کسب‌شده، در جدولی مرتب شدند، بیشترین امتیاز کسب‌شده مربوط به کاهو، بنفشه و کدو بود که اثرات خواب‌آوری یا آرام‌بخشی این گیاهان در مطالعات حیوانی یا انسانی به اثبات رسیده است. بحث و نتیجه‌گیری: لیست مفردات دارویی حاصل‌شده در این مطالعه، می‏تواند زمینه‌ساز انجام مطالعات بالینی آینده برای ساخت داروهای جدید و مؤثر در درمان بی‌خوابی باشد.Introduction:&nbsp;Insomnia is a common sleep disorder that can affect the mood, alertness, memory, security and daily functioning. Currently, the most commonly used drugs in the treatment of insomnia are the benzodiazepines, whose incidence of adverse events, such as cognitive disorders, drug dependence and reversal of symptoms after discontinuation restricts their use. This necessitates the need for more efficient treatments. In Iranian traditional medicine, insomnia and its therapies are widely discussed. In this study, it is revised the effect of materia medica on insomnia in traditional medicine. Method:&nbsp;This study is a library and literature review. The effective drugs in treating insomnia are searched in six reference books on pharmacology of traditional medicine, including The Canon of medicine, Alabnie an haghayegh al Advie, Reyaz al Advie, Tazkare Davood Antaki, Tohfat Al-momenin and Makhzan-al-advie. The study is performed in several stages (finding keywords, searching for resources, and preparation of lists, finding synonyms, classifying, summarizing and rating the results by scores). Results:&nbsp;28 materia medica were found to the treat insomnia, among which 25 cases had a plant origin and the rest were of animal origin. The results of this study are sorted in a table based on their score of effectiveness. The highest scores found to correspond to Lactuca sativa L., Viola odorata and&nbsp;Cucurbita moschata&nbsp;whose sedative and hypnotic effects have been shown in animal or human studies. Discussion &amp; Conclusion:&nbsp;The obtained results showed that materia medica can help to conduct future clinical trials to obtain new drugs which are effective in insomnia treatment

درمان‌های بی‏خوابی از دیدگاه طب سنّتی ایران و مقایسه آن با طب نوین

Background: Insomnia is one of the most prevalent sleep disorders which affect the quality of life. Due to high prevalence of this disease and the side effects of sedative drugs and an increase in people tend to use herbal remedies, this study was designed. This study aims at investigating various treatments for insomnia in Iranian traditional medicine and comparing them with current therapies in modern medicine. Materials and methods: This study is reviews Iranian traditional medicine textbooks and their contents about insomnia and its treatments which are separately expressed and explained. In addition, new articles are reviewed as well to be able to compare modern and traditional treatments. Results: In the viewpoint of Iranian traditional physicians, sleep hygiene is essential to treat insomnia. For this purpose, they suggest some special foods, simple and complex drugs and soma activities. They prescribe different types of drug use, such as intranasal and topical drug consumption. In addition, they suggest anointing the forehead or feet, and foot massage as treatments of insomnia. Reviewing modern treatments of insomnia with In Iranian traditional medicine’s treatment revealed that in Iranian traditional medicine, both topical methods and oral medication are suggested, whereas in modern medicine often oral therapy and cognitive-behavioral therapy are used and topical treatments are rarely adopted. Conclusions: It seems that topical application of drug in insomnia treatment which is suggested in Iranian traditional medicine can reduce the side effects are caused by oral consumption of the drugs. This study can be helpful to remove some of the side effects of modern medicine and we hope that by combining traditional and modern therapies, a more helpful treatment for insomnia is achieved.مقدمه: بی‏خوابی از شایع‌ترین اختلالات خواب است که بر کیفیت زندگی تأثیر به‎سزایی دارد. این بیماری در متون طب سنّتی ایران «سَهَر» نامیده می‌شود. با توجه به میزان شیوع بالای این بیماری و عوارض جانبی داروهای خواب‌آور و افزایش تمایل مردم برای استفاده از داروهای گیاهی، مطالعه حاضر با هدف بررسی انواع درمان‌های بی‎خوابی از دیدگاه طب سنّتی ایران و مقایسه‌ آن با درمان‌های رایج در طب نوین طراحی شد. روش کار: در این تحقیق، متون به روش کتابخانه‌ای بررسی می‎شوند. حاصل کار بر روی متون معتبر طب سنّتی ایران است که مطالب مربوط به بی‎خوابی و درمان‌های آن به تفکیک بیان شده است. از طرفی مقالات و تحقیقات جدید نیز بررسی شده‎اند. یافته‌ها: پزشکان طب سنّتی ایران برای درمان بی‎خوابی، رعایت حفظ‌الصحه خواب را ضروری می‌دانند و سپس تدابیر غذایی، استفاده از داروهای مفرد و مرکب و اَعمال یداوی را تجویز می‌کنند. آنان انواع روش‌های استنشاقی و موضعی مصرف دارو مانند روغن‌مالی پیشانی، ملاج سر و کف پا، استعمال انواع آبزن‌ها، پاشویه و ماساژ کف پا مانند داروهای خوراکی برای درمان بی‏خوابی را تجویز می‏کنند، درحالی‌که در طب نوین اغلب، روش‏های خوراکی و شناختی- رفتاری در درمان بی‎خوابی استفاده می‌شوند و درمان‌های موضعی کمتر به‏کار می‏روند. نتیجه‌گیری: استفاده از انواع روش‌های موضعی مصرف دارو در درمان بی‎خوابی در طب سنّتی موجب کاهش عوارض جانبی در مقایسه با روش خوراکی می‏شود و این امر می‌تواند راهگشای درمان در بسیاری از بیماران گرفتار عوارض جانبی داروهای طب نوین باشد

The comparison of fennel infusion plus dry cupping versus metformin in management of oligomenorrhoea in patients with polycystic ovary syndrome: a randomised clinical trial

Oligomenorrhoea treatment with hormone therapy and Metformin is not usually well tolerated and is associated with a broad range of side effects. In Persian medicine, the management of oligomenorrhoea can be done with fennel and dry cupping. A clinical trial was conducted on 61 patients with oligomenorrhoea. The patients randomly received treatment for 6 months in two groups: fennel infusion plus dry cupping (Group A); versus treatment with Metformin (Group B). On the days between the two periods, the patients� BMI, pain levels and side effects were assessed. Thirty-one patients (mean age: 26.68) in Group A, and 30 patients (mean age: 28.90) in Group B were enrolled. The mean numbers of days between the two periods after 3 and 6 months in Group A was, respectively, 32.59 and 30.69, versus 40.66 and 431.22 in Group B. The mean pain severity dropped significantly in Group A. Fennel seed infusion plus a dry cupping uses a safe and effective therapeutic intervention in the management of oligomenorrhoea.IMPACT STATEMENTWhat is already known on this subject? Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women. Some common clinical manifestations of this syndrome include menstrual disorders such as oligomenorrhoea and amenorrhoea. The recommended therapeutic interventions include oral intervention, as well as metformin, which are associated with an increased risk of vascular thromboembolism, digestive complications such as nausea, and dizziness, and vitamin B12 deficiency. Therefore, the use of complementary medicine in controlling and treating PCOS is considered a valuable intervention in conventional medicine. In Persian traditional medicine, medicinal fennel (with the scientific name of Foeniculum Vulgare Mill) is commonly used in this regard. The practice of dry cupping during the monthly period that ends with ovulation is also recommended. What do the results of this study add? The present study concludes that fennel seed infusion plus a dry cupping therapy is effective and safe in reducing the days between two menstrual periods and manages oligomenorrhoea. What are the implications of these findings for clinical practice and/or further research? A clinical study is suggested for assessing the effect of fennel seed infusion plus dry cupping on oligomenorrhoea, with a large sample size and a longer follow up time. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group

Fertility Diet for Women in Persian Medicine

No Abstrac