4 research outputs found
MRI Findings in Children with the First Unprovoked Seizure Presenting to the Emergency Department; Does Developmental Delay Suggest the Importance of Brain MRI Evaluation?
Introduction: The first unprovoked seizure (FUS) in children is a convulsive seizure with an unknown cause, which may be due to an underlying neurological disease or a manifestation of epilepsy. Objective: The aim of this study was to evaluate the findings of brain magnetic resonance imaging (MRI) in pediatric patients with FUS, presenting to the emergency department (ED). Methods: In this cross-sectional study, all children with FUS (age: >1month and<14 years), who were referred to the ED of Qaem Hospital, Mashhad, Iran from 2016 to 2019, were investigated. Medical records, brain MRI findings, electroencephalography (EEG) results, and developmental status of children were reviewed retrospectively. Results: The brain MRI findings of 56 children with FUS were reviewed. The mean age of children was 3.92±6.05 years, and the sex distribution was equal. Seventeen (30.4%) patients had abnormal EEG findings, while 13 (23.2%) patients’ had non-specific EEG findings. Neurological examination of 4 (7.1%) children was abnormal. Overall, 6 (10.7%) patients had non-specific abnormal brain MRI findings for seizure, while 3 (5.4%) patients had specific abnormal findings. A significant relationship was observed between the developmental status of children and abnormal MRI findings (P=0.04). However, MRI findings had no significant relationship with EEG or neurological findings (P>0.05). Conclusion: It may be useful to perform brain MRI for children with FUS presenting to ED, especially those who are suspected of developmental disorders
MRI Findings in Children with the First Unprovoked Seizure Presenting to the Emergency Department; Does Developmental Delay Suggest the Importance of Brain MRI Evaluation?
Introduction: The first unprovoked seizure (FUS) in children is a convulsive seizure with an unknown cause, which may be due to an underlying neurological disease or a manifestation of epilepsy. Objective: The aim of this study was to evaluate the findings of brain magnetic resonance imaging (MRI) in pediatric patients with FUS, presenting to the emergency department (ED). Methods: In this cross-sectional study, all children with FUS (age: >1month and<14 years), who were referred to the ED of Qaem Hospital, Mashhad, Iran from 2016 to 2019, were investigated. Medical records, brain MRI findings, electroencephalography (EEG) results, and developmental status of children were reviewed retrospectively. Results: The brain MRI findings of 56 children with FUS were reviewed. The mean age of children was 3.92±6.05 years, and the sex distribution was equal. Seventeen (30.4%) patients had abnormal EEG findings, while 13 (23.2%) patients’ had non-specific EEG findings. Neurological examination of 4 (7.1%) children was abnormal. Overall, 6 (10.7%) patients had non-specific abnormal brain MRI findings for seizure, while 3 (5.4%) patients had specific abnormal findings. A significant relationship was observed between the developmental status of children and abnormal MRI findings (P=0.04). However, MRI findings had no significant relationship with EEG or neurological findings (P>0.05). Conclusion: It may be useful to perform brain MRI for children with FUS presenting to ED, especially those who are suspected of developmental disorders
The Impact of Fasting on Metabolic and Anthropometric Parameters in Type II Diabetic Patients: A Prospective Observational Study
Introduction: Fasting has certain effects on metabolic and
anthropometric parameters in diabetic patients. It is therefore,
necessary for patients to receive proper instructions about their
physical activities, eating habits, blood glucose monitoring and
medications.
Aim: To investigate the effects of fasting on metabolic and
anthropometric indices in type II diabetic patients.
Materials and Methods: This prospective observational study
was performed during Ramadan 2018. The study population
consisted of 40 type II diabetic patients (33 females and 7 males)
who wished to fast. They started to follow given instructions on
their physical activity, eating habits, blood glucose monitoring,
and medications before Ramadan. Anthropometric variables
were measured pre and post-Ramadan. Fasting Blood/Plasma
Glucose (FBG/FPG), Glucose 2 Hour Postprandial (2h PPG),
glycosylated haemoglobin (HbA1c), and the lipids profile were
assessed before and after Ramadan. FPG and 2h PPG were
also evaluated on the fifteenth day of Ramadan. Data were
presented as mean±SD. Paired t-test was employed and a
p-value of <0.05 was considered statistically significant.
Results: After completion of the study, anthropometric variables
of patients, including weight (74.9±12.7 vs. 73.0±13.1 kg,
p<0.001), BMI (29.9±5.2 vs. 29.0±5.1 kg/m2
, p=0.042), waist
circumference (106.2±11.8 vs. 105.3±11.6 cm, p<0.001),
conicity index (9.94±0.96 vs 9.80±0.99, p=0.085), systolic blood
pressure (118.5±10.6 vs. 113.8±9.4 mmHg, p=0.018), Diastolic
blood pressure (72.0±7.9 vs. 68.3±7.0 mmHg, p=0.02) and
FPG (125.1±27.4 vs. 105.2±21.4 mg/dL, p<0.001) decreased
significantly. However, serum triglyceride increased significantly
(127.5±45.5 vs. 166.5±53.5 mg/dL, p<0.001) after fasting
compared to pre-Ramadan measurements. Changes in other
variables were not statistically significant.
Conclusion: The results of this study indicate that fasting
had beneficial effect on fasting blood glucose level and
anthropometric parameters in type II diabetic patients